The 31st Bubble Wrap

Cite this article as:
Grace Leo. The 31st Bubble Wrap, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.20429

Article 1: An egg a day keeps the doctor away? (Ecuador)

Ianotti LL, et al. Eggs in Early Complementary Feeding and Child Growth: A Randomized Controlled Trial. Pediatrics; 2017 July [epub] doi: 10.1542/peds.2016-3459

What’s it about?

Childhood stunting is contributed to by both biological factors and environmental factors such as poverty. The World Health Assembly has set a global target to reduce childhood stunting by 40% by 2025. Previous interventions to improve growth have included fortification of food and dietary supplementation. Utilising locally available nutritious food is an important step improving outcomes. Eggs have high nutritional value and contain high concentrations of choline, a nutrient previously found to promote growth in animal models.  There has been no previous study investigating the use of eggs as a complementary nutrition source for infants.

Why does it matter?

The study was completed in Cotopaxi Providence, a rural, indigenous population in Ecuador. This population is estimated to have a baseline prevalence of stunting of 38%. Children aged 6 to 9 months were randomised to treatment (1 egg per day for 6 months [n=83], and control (no intervention [n=80]). Children were excluded if they had a medical condition, severe malnutrition or egg allergy. Eggs were delivered on a weekly basis and a log report egg consumption, morbidities, and anthropometric measures were taken after 6 months. Egg intervention increased length-for-age z score by 0.63 (93% CI, 0.38-0.88, p<0.001), and weight-for-age z score by 0.61 (95% CI 0.45-0.77, p<0.001).  There was a reduced prevalence of stunting by 47% (prevalence ratio, 0.53; 95% CI, 0.37-0.77).  Children in the treatment group also had reduced intake of sugar-sweetened foods compared with control (PR, 0.71; 95% CI, 0.51-0.97 p=0.032). 

Clinically Relevant Bottom Line:

This study found that supplementing the diet 6 to 9-month-olds with an egg a day significantly improves linear growth and reduces stunting within a population from a developing country with a high prevalence of stunting (38%). There were no reports of allergic reactions. Care must be taken in applying this study to different contexts and cultural backgrounds.

Reviewed by: Lorraine Cheung

 

Article 2: Maternal influenza immunisation to improve infant outcome (Nepal)

Steinhoff MC, et al. Year-round influenza immunisation during pregnancy in Nepal: a phase 4, randomised, placebo-controlled trial. Lancet Infect Dis. 2017 Sep;17(9):981-989

Why does it matter?

Influenza can cause serious illness in children, especially infants younger than 6 months of age. Immunisations are strongly recommended to pregnant woman and any child over 6 months of age. Maternal immunisation during pregnancy induces high levels of maternal antibodies that can be transferred to the foetus and prevents influenza virus infection both in pregnant women and their infants during their first few months of life.

What’s it about?

This randomised controlled trial assessed the safety and efficacy of maternal influenza immunisations in mothers and infants in Nepal, where Influenza viruses circulate perennially.  They recruited 3693 women in 17 to 34 weeks of gestation between 2011 to 2013. Maternal influenza immunisations were offered throughout the year, with 3629 infants included in the immunisation efficacy analysis.

The study found that influenza immunisation reduced maternal febrile influenza-like illness with an overall efficacy of 19% (95% CI 1-34).  Among infants followed from birth to six months of age, immunisation had an overall efficacy of 30% (95% CI 5-48. There was also a 42g increase in birth weight (95% CI: 8-76) among infants born to immunised mothers (with an overall decrease in low birth weight infants by 15%). There were no differences noted in the rates of small for gestational age infants or preterm birth. Both groups had a similar number of adverse events.

Clinically Relevant Bottom Line:

Maternal influenza immunisation reduced maternal influenza-like illness, influenza in infants and rates of low birth weight in Nepal. Maternal immunisation should be considered in subtropical regions where the virus is present for many months.

Reviewed by: Jessica Win See Wong

 

Article 3: Comparing infusion rates of fluid boluses in septic shock (India)

Sankar J et al. Fluid Bolus Over 15-20 Versus 5-10 Minutes Each in the First Hour of Resuscitation in Children With Septic Shock: A Randomized Controlled Trial. Pediatric Critical Care Medicine. 2017 Oct; 18(10)

What’s it about?

This was a randomised controlled trial where the researchers identified children with septic shock in paediatric ED and ICU in a tertiary hospital in northern India, and compared intravenous fluid boluses of 40-60mL/kg per hour in 20mL/kg aliquots delivered over 15-20 minutes versus over 5-10 minutes. Primary outcomes were the need for mechanical ventilation and/or impaired oxygenation. There were several other secondary objectives.

Subjects were aged 9 months to 12 years and included children with suspected infection with two or more clinical signs of decreased perfusion. They excluded children with dengue, malaria, severe anaemia, severe malnutrition, primary cardiac illness, those on non-invasive ventilation before developing shock, those who had already received fluids or inotropes, and those with contraindications to central line insertion.

This was a small RCT, with only 96 children randomised. The study was terminated after about 50% enrolment after interim analysis suggested harm in the 5-10 minute group. They found that children who received fluid boluses over 5-10 minutes were at higher risk of intubation and mechanical ventilation, had higher rates of intubation due to fluid overload, and had higher percentages of fluid overload in 24 hours. There was no difference in the mortality rate.

Why does it matter?

Recognition and treatment of sepsis is huge in acute paediatrics. Guidelines around the world recommend treating septic shock with fluid resuscitation of up to 60mL/kg as boluses, although the 2011 FEAST trial highlighted the potential harms of fluid boluses, suggesting a cautious approach to fluid bolus administration.

Instead of looking at different fluid volumes or types of fluid, this study compared infusion times. Unlike in the FEAST study, they excluded children vulnerable to the effects of fluid overload, allowing for more broad applicability of the results. Both groups of children received almost identical volumes of fluid as boluses; it was only the infusion times that differed.

The researchers suggested that rapid fluid bolus administration is difficult in developing countries due to a shortage of staff to administer the boluses, and fear of fluid overload and need for ventilation, which is not easy to achieve in resource-restricted settings.

The Bottom Line

Research is yet to identify the optimal fluid management of septic shock in developing and developed countries, so in the meantime caution is prudent.

Reviewed by: Katie Nash

 

Article 4: Think zinc! (India)

Negi K et al. Serum zinc, copper and iron status of children with coeliac disease on three months of gluten-free diet with or without four weeks of zinc supplements: a randomised controlled trial. Trop Doct. 2018; 48(2): 112-116. Doi: 10.1177/0049475517740312.

Why does it matter?

Coeliac disease is characterised by gluten intolerance which leads to damage to the small bowel mucosa via an autoimmune process in genetically susceptible individuals. Partial or total villous atrophy affects the maintenance of nutrients. Zinc is implicated in the improvement of mucosal healing and faster normalisation of micronutrient status in susceptible patients. Therefore, zinc supplementation may prove to be beneficial in patients with coeliac disease.

What’s it about?

This study compares the serum zinc, iron and copper status in paediatric patients following a gluten-free diet with or without zinc supplementation. All children aged <18 years with newly diagnosed coeliac disease were randomised to either the gluten-free diet (GFD) group or the glute-free diet + zinc supplementation (GFD+Zn) group via computer-generated random sequences. Patients were assessed with clinical history, examination and blood tests at baseline and various follow-up review up to 3 months. Unsurprisingly, iron, zinc and copper levels were below the normal range at baseline in all patients. The rise in haemoglobin, serum iron and ferritin levels was better in the GFD+Zn group than the GFD alone group. Otherwise, there was no significant difference in the rise of zinc, copper and weight gain in the two groups.

Clinically Relevant Bottom Line:

The study has shown that zinc supplementation significantly improves iron status but does not affect serum zinc or copper levels. The authors speculate this may be secondary to the contributory effect of zinc towards mucosal healing and improvement of intestinal absorption. Although interesting, it would have been helpful to couple these biochemical results with endoscopic findings with zinc supplementation. Nevertheless, the mainstay of treatment for coeliac disease remains the gluten-free diet and you may think of supplementing zinc if you want a faster improvement in iron status

Reviewed by: Jennifer Moon

 

Article 5: The power of playtime (Ethiopia)

Worku, B.N., et al  Effects of home-based play-assisted stimulation on developmental performances of children living in extreme poverty: a randomized single-blind controlled trial. BMC Paediatrics. 2018 Vol 18. doi: 10.1186/s12887-018-1023-0.

Why does it matter?

A child’s development is dependent on social, economic and environmental factors. In third world countries where children are brought up in extreme poverty, a multitude of factors negatively impacts their development. We know that early intervention can prevent developmental loss, in both developed and developing countries. The challenge is finding a sustainable way to deliver effective intervention.

What’s it about?

The study looked at foster children aged between 3 and 59 months, living with foster mothers in Jimma, a town in Ethiopia. The children were randomly assigned to intervention and control groups at a 1:1 ratio. The intervention group received home-based play stimulation once a week for 6 months, which focused on activities to promote developmental skills and mother-child interactions. The therapy was provided by a trained nurse, however, they also spent time teaching the foster mothers, so they could provide ongoing play therapy at home.

The assessors, who were blinded to the children’s allocations, used culturally specific and standardized developmental screening tools, at baseline, 3 months and 6 months. The study found that intervention was beneficial for language, social-emotional and personal-social performances (statistically significant for language [P = 0.0014], personal-social [P = 0.0087] and social-emotional [P < 0.0001] performances).

Clinically Relevant Bottom Line:

The study showed positive effects on multiple domains of development in the 6 months of follow up for children who received home-based play therapy. This approach is highly sustainable, as the foster mother’s acquired skills means they can continue to provide play therapy and hopefully, continue to have positive effects on children living in resource-limited settings.

Reviewed by: Tina Abi Abdallah

 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments! We are also looking to expand the Bubble Wrap team so please contact us if you’re interested in this! That’s it for this month. Many thanks to all of our reviewers who have taken the time to scour the literature so you don’t have to. 

The 30th Bubble Wrap

Cite this article as:
Grace Leo. The 30th Bubble Wrap, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.19868

Article 1: What’s the risk of infants 29-90 days having both UTI and meningitis?

Nugent, J., et al Risk of Meningitis in Infants Aged 29 to 90 Days with Urinary Tract Infection: A Systematic Review and Meta-Analysis. Journal of Paediatrics; 2019 June [eprint] doi: 10.1016/j.jpeds.2019.04.053

What’s it about?

UTI remains the most common serious bacterial infection in infants, and infants under 28 days routinely undergo a complete septic work up when presenting to ED with a fever. For infants aged between 29 – 90 days, the decision to LP is guided by clinical findings and left up to the treating physician. So, what are the chances that febrile baby with the positive urinalysis also has meningitis?

Why does it matter?

This systematic review looked at the pooled prevalence of co-existing meningitis, bacterial or aseptic. The authors searched 3 databases for studies reporting on the rates of meningitis in infants aged 29 – 90 days who had abnormal urinalysis or culture results (but were not necessarily febrile at presentation) who also had LPs performed as part of their work up. A total of 20 studies (3 prospective and 17 retrospective) were identified.

The review found the pooled prevalence of concomitant bacterial meningitis in infants with UTI was 0.25% (95% CI, 0.09%-0.70%). This translates to a number needed to investigate with LP for 1 diagnosis of meningitis of 400. The pooled prevalence for aseptic meningitis over the 20 studies was not able to be calculated, but in some studies the prevalence was as high as 29%.

Clinically Relevant Bottom Line:

Based on this systematic review, the risk of bacterial meningitis in infants aged 29-90 days with evidence of UTI is low, but the decision to LP should always take into consideration the clinical picture, as opposed to a calculated pre-test probability.

Reviewed by: Tina Abi Abdallah

Article 2: Anima sana in corpore sano: Does a healthy body equal a healthy soul?

Easterlin MC, et al. Association of Team Sports Participation With Long-term Mental Health Outcomes Among Individuals Exposed to Adverse Childhood Experiences. JAMA Pediatr. 2019 May 28 [Epub ahead of print].

What’s it about?

Adverse childhood experiences (ACEs) and/or mental health problems are unfortunately very common, but the impact and extent of these events may differ from person to person. This article addresses whether team sports may influence well being in adulthood after ACEs. ACEs were defined as physical and sexual abuse, emotional neglect, parental alcohol misuse, parental incarceration, and living with a single parent extracted from the data of the National Longitudinal Study of Adolescent to Adult Health (National Population sample of US adolescents – 1994 and 2008). Multivariable logistic regression models were used to score factors associated with team sport participation. About half of the participants (9668 individuals included in the study – 4888 (49.3%)) reported 1 or more ACEs. Among those with ACEs, team sports participation during adolescence was significantly associated with lower odds of receiving a diagnosis of depression, anxiety or having current depressive symptoms (adjusted odds ratios, 0.76, 0.70 and 0.85 respectively).

Why does it matter?

Adverse childhood experiences can have long-term mental health consequences, but the knowledge of factors improving mental health after these events is lacking. This study showed an association with team spots and improved mental health and could be an ‘easy’ tool to improve well being in traumatised children.

Clinically Relevant Bottom Line:

Team sport participation in adolescence was associated with better mental health outcomes in children with ACEs. As suggested by the authors, team sports may be an important and scalable resilience builder.

Reviewed by: Anke Raaijmakers 

Article 3: Another look at risk factors for cervical spine injury in children with blunt trauma

Leonard JC, et al. Cervical Spine Injury Risk Factors in Children with Blunt Trauma. Pediatrics 2019, 144 (1). doi.org/10.1542/peds.2018-3221

What’s it about?

Four tertiary care hospitals which are part of the USA based Paediatric Emergency Care Applied Research Network (PECARN) ran a prospective observational study to look at risk factors of cervical spine injury in children with blunt trauma. They then compared the PECARN model with a de novo model of risk factors. After screening  11809 children with blunt trauma, approximately were found to be eligible and 4144 children were enrolled. Of 4091 children, 1.8% (74) had a cervical spine injury.  Children who didn’t receive cervical spine imaging had medical record and subsequent call follow up (if no imaging) to verify the absence of injury.  Treating ED providers filled out electronic questionnaire prior to knowledge of cervical spine image results. These questionnaires assessed for risk factors including injury mechanism, patient variables and physical findings.

Fourteen risk factors were identified as having significant association with CSIs in this study. PECARN criteria currently include 8 risk factors (high-risk MVC, diving mechanism, conditions predisposing for CSI, neck pain, reported inability to move neck, altered mental status, limited neck range of motion on exam, substantial torso injury and focal neurological deficits). Three of these variables were not found to be independently associated with CSIs in the analysis of data collected: high risk MVC, conditions predisposing for CSI and limited neck range of movement on examination

A de novo model was proposed of 7 variables: diving mechanism, axial load, neck pain, reported inability to move neck, altered mental status, respiratory distress, and intubation.

Comparing PECARN with this de novo model slightly increased the sensitivity (90.5 to 91.9%) and specificity (45.6% to 50.3%). Extrapolated imaging rates using the PECARN and de novo risk model would decrease from 78.2% to 55.1% and 50.5% respectively and roughly halve CT scan. Both models missed children with CSIs – 7 in PECARN and 6 with the de novo model however on retrospective chart review 6 of the 7 missed children had a PECARN risk factor. None of those missed had surgical intervention but two were managed with medical devices (brace or rigid cervical collars).

The Bottom Line

This study presents data from 4 US trauma centres to improve identification of cervical spine injury risk factors in children. A de novo model with 7 risk factors has been examined and compared with the existing PECARN model and would yield slightly improved results and would have missed one less child with CSI in the group of over 4000 children studied.

Reviewed by: Grace Leo

Article 4: Drowning in the school holidays

Peden A et al. The association between school holidays and unintentional fatal drowning among children and adolescents aged 5-17 years. Journal of Paediatrics and Child Health. 2019 May; 55(5), pp. 533-538.

Why does it matter?

Australia is an island with 85% of its population living within 50 km of the coastal line. Thanks to a mostly temperate climate, many families and young people enjoy spending time at beaches, rivers and lakes, as well as many households having swimming pools. Therefore, drowning becomes a very real problem, especially for children and young people. In fact, drowning is a leading killer of young people, however children and adolescents aged 5-17 years have one of the lowest rates. This could be due to the protective effect of time spent in formal schooling and this study shows how the risk of drowning differs during time spent at school versus school holidays.

What’s it about?

The investigators extracted the data from the Australian Royal Life Saving National Fatal Drowning Database over 2005-2014. A total of 188 children/adolescents aged 5-17 years drowned during the study period. There was a significant difference between drowning incidence during school holidays (including public holidays) and school days (P value <0.01), with relative risk (RR) of drowning on a holiday being 2.40 times higher than on a school day (CI 1.82-3.18). The risk was higher for children 5-9 years (RR = 3.05; CI 1.98-4.72) than adolescents 10-17 years (RR = 2.02; CI 1.38-2.93). The risk was similar for males and females in this age group. Most drowning incidents occurred at a river, creek or stream, as opposed to a beach or swimming pool.

Clinically Relevant Bottom Line:

As might be expected the rate of drowning in children and adolescents is much higher during school holidays than during formal schooling (with this study finding a relative risk 2.4 times higher). Although there are limitations to this study,  it advocates for ongoing drowning risk reduction strategies but particularly in the lead-up to school holiday periods in school-aged children and adolescents.

Reviewed by: Jennifer Moon

Article 5: The global impact of rotavirus vaccine in children under 5 years of age

Aliabadi N, et al. Global impact of rotavirus vaccine introduction on rotavirus hospitalisations among children under 5 years of age, 2008–16: ndings from the Global Rotavirus Surveillance Network. Lancet Glob Health 2019; 7: e893-903

Why does it matter?

In 2015, Rotavirus gastroenteritis  accounted for an estimated 250,000 deaths and 1·9 million episodes per year of severe acute gastroenteritis requiring hospital admis­sion in the under 5 year old age group. This paper cites that rotavirus vaccination has an efficacy of ranging from 57% to 85% for RV1 and from 45% to 90% for RV5 based on countries’ mortality strata. WHO recommends rotavirus vaccination as part of the national immunisation scheme for all countries. This study helps to assess the impact of introduction of rotavirus vaccinations.


What’s it about?

This paper presents the findings of the World Health Organisation (WHO) co-ordinated Global Rotavirus Surveillance Network (GRSN) to examine the rates of rotavirus confirmed hospital admissions prior to and following introduction of rotavirus vaccine globally between 2008-16 across 69 countries. Whilst it covers areas in Africa, the Americas, Eastern Mediterranean and European region, some of the countries the GRSN does not include are UK, American, Canadian, Russia, Australia or New Zealand. As China joined after 2016 it was also not included in the assessed population.

The prospective study looked at children under 5 years old admitted to hospital across the GRSN sites with acute gastroenteritis who subsequently had stool PCR within 48 hours to assess for rotavirus infection. It assessed the difference in cases pre and post-vaccine periods. The was a main analysis of data included sites with over 1 year of enrolment and over 100 specimens tested per year (305789 cases across 69 countries). Three further sensitivity analysis looked at cases 1) that did not have both pre and post vaccine data 2) regions with vaccine coverage <60% or vaccine not introduced, 3) Slightly relaxed lab inclusions to account for smaller labs. There was insufficient data to be able to combine these three groups. The study reports one third of children (32.9%) included had confirmed rotavirus gastroenteritis. Presentations of rotavirus gastroenteritis reduced 38% pre-vaccination to 23% post vaccination of cases included (with a relative reduction of 39.6%, CI 35.4-43.8). This data uses the mean proportion of children who were positive and the actual range between the two groups overlapped. The three other sensitivity analysis showed similar rates of overall reduction in rotavirus presentations.

The Bottom Line

This WHO-GSRN large impact analysis of rotavirus vaccination in children under 5 included 305,789 children, of which one third had confirmed rotavirus gastroenteritis. Between pre and post-vaccination periods, there was a relative decline in rotavirus gastroenteritis hospital presentations of almost 40%.  Rotavirus vaccination is effective in reducing hospital admissions for rotavirus gastroenteritis and should be considered for introduction in countries not yet covered such as part of Africa and southeast Asia.

(Ed note: If you’re interested in gastroenteritis, you may also be interested to know that Archives of Disease of Childhood has just published a systematic review and meta-analysis looking at Gelatin tannate (a protective gelatin with  astringent, antibacterial, and anti-inflammatory properties) in the use of acute diarrhoea and gastroenteritis in children. There was no difference with placebo).

Reviewed by: Grace Leo

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments! We are also looking to expand the Bubble Wrap team so please contact us if you’re interested in this! That’s it for this month. Many thanks to all of our reviewers who have taken the time to scour the literature so you don’t have to. 

Bumper Bubble Wrap PLUS – May/June 2019

Cite this article as:
Anke Raaijmakers. Bumper Bubble Wrap PLUS – May/June 2019, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.19367

Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list  from Anke Raaijmakers working with Professor Jaan Toelen & his team of the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or simply help you to keep an finger on the pulse of paediatric research.

This list features answers to intriguing questions such as: ‘Is it time to stop checking gastric residual volume in neonates?’, ‘Do we need to flush peripheral catheters?’, Is methotrexate a good drug to treat atopic dermatitis?’, ‘How long does the DTP vaccine provide protection?’, ‘Is routine ultrasound for the hip necessary after breech presentation?’, ‘For which children is team sport participation associated with better adult mental health?’,  ‘What is the outcome after a 10-min APGAR score of zero?’ and ‘What is the effect of online health information (Dr Google) on trust in pediatricians’ diagnoses?’.

You will find the list is broken down into four sections:

MAY PAPERS

1.Reviews and opinion articles

Glucocorticoids for Croup in Children.

Gates A, et al. JAMA Pediatr. 2019 Apr 29.

The role of objective tests to support a diagnosis of asthma in children.

Danvers L, et al. Paediatr Respir Rev. 2019 Feb 28.

Invasive group A streptococcal disease: Management and chemoprophylaxis.

Moore DL, et al. Paediatr Child Health. 2019 May;24(2):128-129.

Relaxation training for management of paediatric headache: A rapid review.

Thompson AP, et al. Paediatr Child Health. 2019 May;24(2):103-114.

Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis.

Niemarkt HJ, et al. Neonatology. 2019 Apr 11;115(4):423-431.

Newborn screening for cystic fibrosis: Is there benefit for everyone?

Course CW, et al. Paediatr Respir Rev. 2019 Feb 28.

Ethical Issues in Perinatal Clinical Research.

Walsh V, et al. Neonatology. 2019 Apr 4;116(1):52-57.

Machine Learning in Medicine.

Rajkomar A, et al. N Engl J Med. 2019 Apr 4;380(14):1347-1358.

The child with an incessant dry cough.

Galway NC, et al. Paediatr Respir Rev. 2018 Aug 30.

2. Original clinical studies

Association of Rhinovirus C Bronchiolitis and Immunoglobulin E Sensitization During Infancy With Development of Recurrent Wheeze.

Hasegawa K, et al. JAMA Pediatr. 2019 Apr 1.

Respiratory Syncytial Virus, Rhinoviruses, and Recurrent Wheezing: Unraveling the Riddle Opens New Opportunities for Targeted Interventions.

Ramilo O, et al. JAMA Pediatr. 2019 Apr 1.

Effect of Gastric Residual Evaluation on Enteral Intake in Extremely Preterm Infants: A Randomized Clinical Trial.

Parker LA, et al. JAMA Pediatr. 2019 Apr 29.

Lack of Efficacy of Lactobacillus reuteri DSM 17938 for the Treatment of Acute Gastroenteritis: A Randomized Controlled Trial.

Szymański H, et al. Pediatr Infect Dis J. 2019 Apr 25.

Flushing of peripheral intravenous catheters: A pilot, factorial, randomised controlled trial of high versus low frequency and volume in paediatrics.

Kleidon TM, et al. J Paediatr Child Health. 2019 Apr 29.

The association between crowding within households and behavioural problems in children: Longitudinal data from the Southampton Women’s Survey.

Marsh R, et al.  Paediatr Perinat Epidemiol. 2019 Apr 29.

Genetic and Early-Life Environmental Influences on Dental Caries Risk: A Twin Study.

Silva MJ, et al. Pediatrics. 2019 Apr 26.

The Association of Paternal IQ With Autism Spectrum Disorders and its Comorbidities: A Population-Based Cohort Study.

Gardner RM, et al. J Am Acad Child Adolesc Psychiatry. 2019 Apr 23.

Rethinking ADHD intervention trials: feasibility testing of two treatments and a methodology.

Fibert P, et al. Eur J Pediatr. 2019 Apr 24.

Long-term effect of methotrexate for childhood atopic dermatitis.

Purvis D, et al. J Paediatr Child Health. 2019 Apr 23.

Sleep-Related Infant Suffocation Deaths Attributable to Soft Bedding, Overlay, and Wedging.

Erck Lambert AB, et al. Pediatrics. 2019 Apr 22.

Effect of Albuterol Premedication vs Placebo on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomies: The REACT Randomized Clinical Trial.

von Ungern-Sternberg BS, et al. JAMA Pediatr. 2019 Apr 22.

Duration of Immunity and Effectiveness of Diphtheria-Tetanus-Acellular Pertussis Vaccines in Children.

Domenech de Cellès M, et al. JAMA Pediatr. 2019 Apr 22.

Contribution of Sensory Processing to Chronic Constipation in Preschool Children.

Little LM, et al. J Pediatr. 2019 Apr 12.

Postvaccination Febrile Seizure Severity and Outcome.

Deng L, et al. Pediatrics. 2019 Apr 19.

The effect of pediatric patient temperament on post-operative outcomes.

Uhl K, et al. Paediatr Anaesth. 2019 Apr 18.

Adolescent and Young Adult Cancer Patients’ Experiences With Treatment Decision-making.

Mack JW, et al. Pediatrics. 2019 Apr 18.

Evaluation of referrals for short stature: A retrospective chart review.

Yue D, et al. Paediatr Child Health. 2019 May;24(2):e74-e77.

Respiratory Viruses Frequently Mimic Pertussis in Young Infants.

Damouni Shalabi R, et al. Pediatr Infect Dis J. 2019 May;38(5):e107-e109.

The Clinical Presentation of Pediatric Mycoplasma pneumoniae Infections-A Single Center Cohort.

Gordon O, et al. Pediatr Infect Dis J. 2019 Apr 10.

Paediatric reference intervals are heterogeneous and differ considerably in the classification of healthy paediatric blood samples.

Alnor AB, et al. Eur J Pediatr. 2019 Apr 17.

Investigating the need for routine ultrasound screening to detect developmental dysplasia of the hip in infants born with breech presentation.

D’Alessandro M, et al. Paediatr Child Health. 2019 May;24(2):e88-e93.

High-density Bacterial Nasal Carriage in Children Is Transient and Associated With Respiratory Viral Infections-Implications for Transmission Dynamics.

Thors V, et al. Pediatr Infect Dis J. 2019 May;38(5):533-538.

Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses.

Sturgeon JP, et al. Pediatr Infect Dis J. 2019 Apr 10.

The Role of Patient and Parental Resilience in Adolescents with Chronic Musculoskeletal Pain.

Gmuca S, et al. J Pediatr. 2019 Apr 10.

Proband and Familial Autoimmune Diseases Are Associated With Proband Diagnosis of Autism Spectrum Disorders.

Spann MN, et al. J Am Acad Child Adolesc Psychiatry. 2019 May;58(5):496-505.

Breastfeeding in Infancy and Lipid Profile in Adolescence.

Hui LL, et al. Pediatrics. 2019 Apr 9. pii: e20183075.

Classic Metaphyseal Lesions among Victims of Abuse.

Adamsbaum C, et al. J Pediatr. 2019 Apr 5.

Postextubation Dysphagia in Pediatric Populations: Incidence, Risk Factors, and Outcomes.

Hoffmeister J, et al. J Pediatr. 2019 Apr 3. pii: S0022-3476(19)30243-4.

Pediatric Septic Arthritis of the Knee: Predictors of Septic Hip Do Not Apply.

Obey MR, et al. J Pediatr Orthop. 2019 Apr 3.

Association between hypotension and serious illness in the emergency department: an observational study.

Hagedoorn NN, et al. Arch Dis Child. 2019 Apr 4.

Association of In Vitro Fertilization With Childhood Cancer in the United States.

Spector LG, et al. JAMA Pediatr. 2019 Apr 1:e190392.

Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms.

López-Vicente M, et al. J Pediatr. 2019 Mar 22.

Molecular Genetic Anatomy and Risk Profile of Hirschsprung’s Disease.

Tilghman JM, et al. N Engl J Med. 2019 Apr 11;380(15):1421-1432.

4. Case reports

Gaze Palsy: An Important Diagnostic Clue.

Madaan P, et al. J Pediatr. 2019 Apr 24.

When Posture Gives the Clue: “Jug Handle Deformity”.

Banerjee A, et al. J Pediatr. 2019 Apr 17.

A 10-year-old female with unilateral seventh cranial nerve palsy.

Gohal S, et al. Paediatr Child Health. 2019 May;24(2):69-71.

A boy with developmental regression.

MacLellan K, et al. Paediatr Child Health. 2019 May;24(2):67-68.

A Healthy Toddler With Fever and Lethargy.

Suri NA, et al. Pediatrics. 2019 Apr 5. pii: e20180412.

Acute encephalopathy associated with influenza infection: Case report and review of the literature.

Albaker A, et al. Paediatr Child Health. 2019 May;24(2):122-124.

JUNE PAPERS

2. Original clinical studies

Risk of invasive bacterial infections by week of age in infants: prospective national surveillance, England, 2010-2017.

Ladhani SN, et al. Arch Dis Child. 2019 May 30.

Impact of paediatric tonsillectomy perioperative management on pain, nausea and recovery: A prospective cohort study.

Richards J, et al. J Paediatr Child Health. 2019 May 29.

Efficacy and safety of systemic hydrocortisone for the prevention of bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.

Morris IP, et al. Eur J Pediatr. 2019 May 29.

Severe Acute Respiratory Failure in Healthy Adolescents Exposed to Trimethoprim-Sulfamethoxazole.

Miller JO, et al. Pediatrics. 2019 May 29.

Retrospective study of budesonide in children with eosinophilic gastroenteritis.

Fang S, et al.Pediatr Res. 2019 May 29.

Care for children with severe chronic skin diseases.

De Maeseneer H, Van Gysel D, et al. Eur J Pediatr. 2019 May 22.

Association of Team Sports Participation With Long-term Mental Health Outcomes Among Individuals Exposed to Adverse Childhood Experiences.

Easterlin MC, et al. JAMA Pediatr. 2019 May 28.

FEEDMI: A Study Protocol to Determine the Influence of Infant-Feeding on Very-Preterm-Infant’s Gut Microbiota.

Morais J, et al. Neonatology. 2019 May 27:1-6.

Association between early life (prenatal and postnatal) antibiotic administration and coeliac disease: a systematic review.

Kołodziej M, et al. Arch Dis Child. 2019 May 25.

The effect of follow-up after a negative double-blinded placebo-controlled cow’s milk challenge on successful reintroduction.

Schrijvers M, et al. Eur J Pediatr. 2019 May 24.

Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children: A Systematic Review.

Singendonk M, et al. J Pediatr Gastroenterol Nutr. 2019 Jun;68(6):811-817.

What does sleep hygiene have to offer children’s sleep problems?

Hall WA, et al. Paediatr Respir Rev. 2018 Nov 9.

Physiological effects of high-flow nasal cannula therapy in preterm infants.

Liew Z, et al. Arch Dis Child Fetal Neonatal Ed. 2019 May 23.

Treatment failure in children diagnosed with constipation in a paediatric emergency department in relation to Rome III criteria.

Eltorki M, et al. Paediatr Child Health. 2019 Jun;24(3):185-192.

Traffic Crashes, Violations, and Suspensions Among Young Drivers With ADHD.

Curry AE, et al. Pediatrics. 2019 May 20.

Preparing for Discharge From the Neonatal Intensive Care Unit.

Gupta M, et al. Pediatrics. 2019 May 3.

Infant Deaths in Sitting Devices.

Liaw P, et al. Pediatrics. 2019 May 20.

Higher Sun Exposure is Associated With Lower Risk of Pediatric Inflammatory Bowel Disease: A Matched Case-Control Study.

Holmes EA, et al. J Pediatr Gastroenterol Nutr. 2019 May 15.

Genetic Associations Between Executive Functions and a General Factor of Psychopathology.

Harden KP, et al. J Am Acad Child Adolesc Psychiatry. 2019 May 15.

Accuracy of surgeon prediction of appendicitis severity in pediatric patients.

Yu YR, et al. J Pediatr Surg. 2019 Apr 24.

Outcomes related to 10-min Apgar scores of zero in Japan.

Shibasaki J, et al. Arch Dis Child Fetal Neonatal Ed. 2019 May 15.

Topiramate plus Cooling for Hypoxic-Ischemic Encephalopathy: A Randomized, Controlled, Multicenter, Double-Blinded Trial.

Nuñez-Ramiro A, et al. Neonatology. 2019 May 15;116(1):76-84.

Risk factors for development of urinary tract infection in children with nephrolithiasis.

Cetin N, et al. J Paediatr Child Health. 2019 May 14.

LISTERIA MENINGITIS IN DANISH CHILDREN 2000-2017: A Rare Event Even in a Country With High Rates of Invasive Listeriosis.

Vissing NH, et al. Pediatr Infect Dis J. 2019 May 15.

Cerebral oxygenation and blood flow in term infants during postnatal transition: BabyLux project.

De Carli A, et al. Arch Dis Child Fetal Neonatal Ed. 2019 May 13.

Machine Learning at the Clinical Bedside-The Ghost in the Machine.

Zorc JJ, et al. JAMA Pediatr. 2019 May 13.

Comparison of Machine Learning Optimal Classification Trees With the Pediatric Emergency Care Applied Research Network Head Trauma Decision Rules.

Bertsimas D, et al. JAMA Pediatr. 2019 May 13.

Adherence to metformin is reduced during school holidays and weekends in children with type 1 diabetes participating in a randomised controlled trial.

Leggett C, et al. Arch Dis Child. 2019 May 11.

Physicians’ Attitudes on Resuscitation of Extremely Premature Infants: A Systematic Review.

Cavolo A, Dierckx de Casterlé B, Naulaers G, et al. Pediatrics. 2019 May 10. pii: e20183972.

Young people’s experiences of brief inpatient treatment for anorexia nervosa.

Thabrew H, et al. J Paediatr Child Health. 2019 May 6.

Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk.

Löwensteyn YN, et al. Eur J Pediatr. 2019 May 6.

Antibiotic Treatment in the First Week of Life Impacts the Growth Trajectory in the First Year of Life in Term Infants.

Kamphorst K, et al. J Pediatr Gastroenterol Nutr. 2019 Apr 15.

Abdominal Wall Pain or Irritable Bowel Syndrome: Validation of a Pediatric Questionnaire.

Siawash M, et al. J Pediatr Gastroenterol Nutr. 2019 May 2.

Virtual Reality for Pediatric Needle Procedural Pain: Two Randomized Clinical Trials.

Chan E, et al. J Pediatr. 2019 Jun;209:160-167.e4.

Paging Dr. Google: The Effect of Online Health Information on Trust in Pediatricians’ Diagnoses.

Sood N, et al. Clin Pediatr (Phila). 2019 May 1:9922819845163.

Nebulised surfactant to reduce severity of respiratory distress: a blinded, parallel, randomised controlled trial.

Minocchieri S, et al. Arch Dis Child Fetal Neonatal Ed. 2019 May;104(3):F313-F319.

Nasal High-Flow Therapy for Newborn Infants in Special Care Nurseries.

Manley BJ, et al. N Engl J Med. 2019 May 23;380(21):2031-2040.

Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.

Lazarus SC, et al. N Engl J Med. 2019 May 23;380(21):2009-2019.

Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes.

LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group, et al. JAMA. 2019 May 7;321(17):1702-1715.

Prepregnancy Body Mass Index, Weight Gain During Pregnancy, and Health Outcomes.

McDermott MM, et al. JAMA. 2019 May 7;321(17):1715.

4. Case reports

Playful Child, Dangerous Intruder: A Case of Silent Foreign Body Aspiration in a 13-Month-Old Boy.

Bradshaw J, et al. Clin Pediatr (Phila). 2019 May 25:9922819851265.

History Matters: A 20-Month-Old Child With Cough and Congestion.

Ellis S, et al. Clin Pediatr (Phila). 2019 May 21:9922819850484.

A Teenager With Painful Oral and Genital Lesions.

DiSantis F, et al. Clin Pediatr (Phila). 2019 May 21:9922819850478.

Hypothermia and Vomiting in a Newborn Without Prenatal Care.

Nichols K, et al. Clin Pediatr (Phila). 2019 May 21:9922819850485.

Vomiting and seizure following circumcision in an infant.

Fleming L, et al. Paediatr Child Health. 2019 Jun;24(3):146-147.

An interlabial mass-like lesion in an otherwise healthy newborn girl.

Navabi B, et al. Paediatr Child Health. 2019 Jun;24(3):143-145.

Blurry Vision and Irregularly Shaped Pupil in a 3-Year-Old Female.

Boye B, et al. Clin Pediatr (Phila). 2019 May 20:9922819850460.

Asymmetric Crying Facies Syndrome.

Ho KY, et al. J Pediatr. 2019 May 3.

Nicolau Syndrome: A Rare Complication following Intramuscular Injection.

Quincer E, et al. J Pediatr. 2019 May 3.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!

The 28th Bubble Wrap

Cite this article as:
Grace Leo. The 28th Bubble Wrap, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.18569

With millions upon millions of journal articles being published every year it is impossible to keep up.  Every month we ask some of our friends from PERUKI (Paediatric Emergency Research in UK and Ireland) to point out something that has caught their eye.

Article 1: To glue or not to glue?

Ste-Marie-Lestage et al. Complications following chin laceration reparation using tissue adhesive compared to suture in children. Injury. 2019 Mar 29. pii: S0020-1383(19)30165-2. doi: 10.1016/j.injury.2019.03.047. [Epub ahead of print]

Why does it matter?

Children, adorable as they are, are a bit clumsy, and often fall over resulting in facial lacerations. These minor traumas often present to ED, and majority are repaired using tissue adhesive, which is fast and pain free. This study aims to determine if the dehiscence rate differed amongst simple wounds repaired with tissue adhesive compared with sutures.

What’s it about?

The electronic records of children presenting to a tertiary paediatric centre (between Dec 2015 and Nov 2017) with a diagnosis of traumatic facial/head lacerations were reviewed. Children who had wounds at risk of infection (i.e. animal bites, heavily soiled, required debridement) or complex wounds (i.e. greater than 5cm, in high mobility areas, extended to muscle layers) were excluded.

A total of 2044 children were eligible, and 89% of the wounds were repaired using tissue adhesive. The primary outcome was dehiscence in the 30 days after repair, with the secondary outcome was infection. Electronic records were reviewed, and parents of eligible children were called and asked about wound healing.

For facial lacerations, there was no statistically significant difference in rates of dehiscence or infection between tissue adhesive and sutures. The same was found for chin lacerations, which have a 5x higher rate of dehiscence compared with other facial lacerations.

Clinically Relevant Bottom Line

As no guidelines exist to guide our decision-making process for using tissue adhesive or sutures, we use our clinical judgement. It is reassuring to know that tissue adhesive does not have statistically significant higher complication rates for low risk wounds, and thus should continue being the first choice for repair.

Reviewed by: Tina Abi Abdallah

Article 2: Long-Term Follow-Up of Infants After a Brief Resolved Unexplained Event–Related Hospitalization

Ari A, Atias Y, Amir J. Long-Term Follow-Up of Infants After a Brief Resolved Unexplained Event-Related Hospitalization. Pediatr Emerg Care. 2019 April 3. doi: 10.1097/PEC.0000000000001816. [Epub ahead of print]

What’s it about?

The change of the terminology of an ALTE (acute life threatening event) to a BRUE (brief resolved unexplained event) by the American Academy of Pediatrics was a welcome change for those who believed a more pragmatic approach to this, not uncommon, presentation was needed. However the change in definition did mean that some children previously categorised as an ALTE may not have had the investigations or observation they would normally have received. This study looked at the outcomes of infants at 5 years following their presentation with a BRUE.

A brief resolved unexplained event (BRUE) is defined as “an event occurring in an infant <1 year of age when the observer reports a sudden, brief and now resolved episode of ≥1 of the following:

  • Cyanosis or pallor
  • Absent, decreased or irregular breathing
  • Marked changes in tone
  • Altered level of responsiveness

Importantly although parental attempts at resuscitation are obviously acknowledged a BRUE diagnosis is based on how the clinician defines the event, and not on a caregiver’s perception that this was a life-threatening event.

This was single-centre retrospective study performed in a relatively large children’s Emergency Department (54,000 children a year) in Israel from 2009-13. These dates are important as (i) data collection very retrospective meaning that it’s difficult to know what the clinicians definitely did and (ii) it predates the emergence of the term BRUE so while strict BRUE criteria were applied to selected patients the concept wasn’t a working diagnosis for clinicians at that time. It is also important to note that only hospitalised children were included i.e. those discharged from ED were not part of the cases. This means that the findings of this study may not be comparable to other centres who discharge directly or admit to an ED short stay unit.

Essentially of 87 child who were followed up via telephone questionnaire 71 (81.6%) were described as having normal development, one (1.1%) child had global developmental delay, 12 (13.8%) had verbal delay and 3 (3.4%) had autistic spectrum disorder. These, apart from a 1% ASD incidence are not grossly different from population statistics. In this cohort 2.3% had had a febrile seizures and 1.15% a non-febrile seizures, again not dissimilar from population norms.

Clinically Relevant Bottom Line:

The longer term outcomes, in this small study, of child with a retrospective diagnosis of a BRUE are not alarming.  A prospective study is clearly needed to confirm this.

Reviewed by: Damian Roland (@damian_roland)

Article 3: Which medication is best for neonatal abstinence syndrome?

Disher at al. Pharmacological Treatments for Neonatal Abstinence Syndrome: A Systematic Review and Network Meta-analysis. JAMA Pediatrics. 2019 Mar; 173(3)

What’s it about?

The aim of this meta-analysis was to compare the different pharmacological agents available for the treatment of neonatal abstinence syndrome (NAS) and identify the most effective therapy in terms of reducing the length of treatment, the length of stay, need for adjuvant therapy and adverse events. The study analysed eighteen randomised clinical trials (N = 1072) which compared buprenorphine, clonidine, diluted tincture of opium and clonidine, diluted tincture of opium, morphine, methadone and phenobarbital. Buprenorphine was found to be the best treatment given the reduction in the length of treatment of 12.75 days (95% CI, -17.97 to -7.58) compared to morphine. Buprenorphine also reduced the length of stay but not the need for adjuvant treatment, compared to other pharmacological agents. On the other hand, morphine and phenobarbital were the worst treatments in terms of relative effects and rankings.

Why does it matter?

Morphine is the most commonly used pharmacological agent in the treatment of NAS, however this meta-analysis suggests that it may be the worst treatment choice in terms of length of treatment and hospital stay! The benefit of buprenorphine could be due to its longer half-life and therefore prevention of sudden withdrawal symptoms. It was also interesting to note the “less mainstream” therapy options, such as diluted tincture of opium, for the treatment of NAS in some centres.

Clinically relevant bottom line:

While the findings of this meta-analysis make us wonder whether buprenorphine should be used more widely as the first line treatment for NAS, the authors emphasise that there is a need for a large multisite trial that compares buprenorphine with other treatments before it can be accepted as the standard treatment for NAS. Watch this space!

Reviewed by: Jennifer Moon

Article 4: Sorry, where was I? I was a little distracted…

Westbrook JI, Raban MZ, Walter SR, Douglas H. Task errors by emergency physicians are associated with interruptions, multitasking, fatigue and working memory capacity: a prospective, direct observation study. BMJ Qual Saf. 2018 Aug; 1;27(8):655-63.

What’s it about?

A team of observers followed 36 emergency physicians around on shift and watched them, in three hour blocks, to codify how many times they were interrupted. By using  WOMBAT (Work Observation Method By Activity Timing) the observers were able to capture the minute-by-minute adventures of the physicians. They found that, on average, an emergency physician was interrupted 7.9 times per hour. They also looked at prescribing errors (by collecting the paper charts) and found 208 prescribing errors in 238 medication orders. Now it must be pointed out that a number of these errors were what is termed as legal errors (unapproved abbreviations for example) rather than clinical errors but this number is still very shocking. Drilling down further in the data it is apparent that interruptions whilst prescribing lead to a 2.82 x increase in clinical errors.

Why does it matter?

It seems that I can barely make it through my first coffee of the shift before someone is handing me an ECG to look at or asking me to review a patient. I’ve switched to drinking long blacks so it doesn’t matter if I have to leave my caffeine but what happens if I am doing something more important – charting medications, working out fluid regimes – for example? This research took place in a department using analog rather than digital prescriptions so one would hope the error rate might be less in this era of the dreaded EMR. For now, though, if I am writing something more than just paracetamol then I’ll try and remain laser-focussed on the task in hand.

Clinically-relevant bottom line?

Doctors get interrupted all the time at work. Whilst the interruptor might think it is a trivial task they have for you it is worth thinking about how you can change the culture to reduce the chance of significant prescribing errors occurring when you are asked to ‘just take a look at this ECG’.

We discussed this post with Casey and the gang at SMACC in Sydney.

Reviewed by: Andrew Tagg (@andrewjtagg)

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments! That’s it for this month. Many thanks to all of our reviewers who have taken the time to scour the literature so you don’t have to.

Bubble Wrap PLUS – April 2019

Cite this article as:
Anke Raaijmakers. Bubble Wrap PLUS – April 2019, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.18568

Welcome to April’s Bubble Wrap Plus, our monthly paediatric journal club provided by Professor Jaan Toelen & his team of the University Hospitals in Leuven (Belgium). This comprehensive list of ‘articles to read’ comes from 34 journals, including Pediatrics, The Journal of Pediatrics, Archives of Disease in Childhood, JAMA Pediatrics, Journal of Paediatrics and Child Health, NEJM, and many more.

This month’s list features answers to intriguing questions (and maybe answers) such as: ‘Do pediatricians follow guidelines when managing status epilepticus in children?’, ‘Does antibiotic prophylaxis for UTI lead to fewer non-UTI infections?’, ‘Is intranasal fentanyl safe for procedural pain management in neonates?’ and ‘Does the early or late introduction of allergens change the development of atopic disease?’.

You will find the list broken down into four sections:

1.Reviews and opinion articles

Helicobacter pylori Infection.

Crowe SE. N Engl J Med. 2019 Mar 21;380(12):1158-1165.

Evaluation of the child with global developmental delay and intellectual disability.

Bélanger SA, et al. Paediatr Child Health. 2018 Sep;23(6):403-419.

Closing the Disclosure Gap: Medical Errors in Pediatrics.

Lin M, et al. Pediatrics. 2019 Mar 13.

Why, when, and how to give surfactant.

Jobe AH. Pediatr Res. 2019 Mar 12.

The pathogenesis and management of renal scarring in children with vesicoureteric reflux and pyelonephritis.

Murugapoopathy V, et al. Pediatr Nephrol. 2019 Mar 7.

Communication with children and adolescents about the diagnosis of a life-threatening condition in their parent.

Dalton L, et al. Lancet. 2019 Mar 16;393(10176):1164-1176.

Communication with children and adolescents about the diagnosis of their own life-threatening condition.

Stein A, et al. Lancet. 2019 Mar 16;393(10176):1150-1163.

Paediatric sarcoidosis.

Nathan N, et al.Paediatr Respir Rev. 2019 Feb;29:53-59.

Human milk as “chrononutrition”: implications for child health and development.

Hahn-Holbrook J, et al.Pediatr Res. 2019 Mar 11. 

2. Original clinical studies

Association Between Year of Birth and 1-Year Survival Among Extremely Preterm Infants in Sweden During 2004-2007 and 2014-2016.

Norman M, et al. JAMA. 2019 Mar 26;321(12):1188-1199.

Management of status epilepticus in children prior to medical retrieval: Deviations from the guidelines.

Uppal P, et al. J Paediatr Child Health. 2019 Mar 28.

What Do NICU Fellows Identify as Important for Achieving Competency in Neonatal Intubation?

Brady J, et al.Neonatology. 2019 Mar 19;116(1):10-16.

Achieving Procedural Competency during Neonatal Fellowship Training: Can Trainees Teach Us How to Teach?

Marrs LK, et al.Neonatology. 2019 Mar 19;116(1):17-19.

Impact of Trimethoprim-sulfamethoxazole Urinary Tract Infection Prophylaxis on Non-UTI Infections.

Desai S, et al.Pediatr Infect Dis J. 2019 Apr;38(4):396-397.

Sleep Problems in Children With Autism and Other Developmental Disabilities: A Brief Report.

Valicenti-McDermott M, et al.J Child Neurol. 2019 Mar 17:883073819836541.

A Validated Scale for Assessing the Severity of Acute Infectious Mononucleosis.

Katz BZ, et al.J Pediatr. 2019 Mar 7.

Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants: The SAIL Randomized Clinical Trial.

Kirpalani H, et al. JAMA. 2019 Mar 26;321(12):1165-1175.

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years.

Brustad N, et al. JAMA. 2019 Mar 12;321(10):1003-1005.

High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants.

Rosendahl J, et al. J Pediatr. 2019 Mar 19. pii: S0022-3476(19)30245-8.

Timing of introduction of allergenic solids for infants at high risk.

Abrams EM, et al. Paediatr Child Health. 2019 Feb;24(1):56-57.

The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods.

Greer FR, et al. Pediatrics. 2019 Mar 18. pii: e20190281.

Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial.

Hamada H, et al. Lancet. 2019 Mar 16;393(10176):1128-1137.

Pediatric Celiac Disease and Eosinophilic Esophagitis: Outcome of Dietary Therapy.

Patton T, et al. J Pediatr Gastroenterol Nutr. 2019 Mar 26.

Host and Bacterial Markers that Differ in Children with Cystitis and Pyelonephritis.

Shaikh N, et al. J Pediatr. 2019 Mar 21. pii: S0022-3476(19)30027-7.

Montelukast and Neuropsychiatric Events in Children with Asthma: A Nested Case-Control Study.

Glockler-Lauf SD, et al. J Pediatr. 2019 Mar 21. pii: S0022-3476(19)30198-2.

Physical Fitness, Physical Activity, and the Executive Function in Children with Overweight and Obesity.

Mora-Gonzalez J, et al. J Pediatr. 2019 Mar 19. pii: S0022-3476(18)31745-1.

Does discharging clinically well patients after one hour of treatment impact emergency department length of stay for asthma patients.

Lenko D, et al. J Paediatr Child Health. 2019 Mar 20.

Characterization of Esophageal Motility in Infants with Congenital Diaphragmatic Hernia using High Resolution Manometry.

Rayyan M, et al. J Pediatr Gastroenterol Nutr. 2019 Mar 5.

Effect of metronome guidance on infant cardiopulmonary resuscitation.

Kim CW, et al. Eur J Pediatr. 2019 Mar 8.

Expressions of Gratitude and Medical Team Performance.

Riskin A, Bamberger P, et al. Pediatrics. 2019 Mar 7.

A cohort study of intranasal fentanyl for procedural pain management in neonates.

McNair C, et al. Paediatr Child Health. 2018 Dec;23(8):e170-e175.

Traumatic brain injury in young children with isolated scalp haematoma.

Bressan S, et al. Arch Dis Child. 2019 Mar 4.

Association of Atopic Dermatitis With Sleep Quality in Children.

Ramirez FD, et al. JAMA Pediatr. 2019 Mar 4:e190025.

3. Guidelines and best evidence

Prevention of Drowning.

Denny SA, et al.Pediatrics. 2019 Mar 15.

Lack of Sleep and Sports Injuries in Adolescents: A Systematic Review and Meta-Analysis.

Gao B, et al. J Pediatr Orthop. 2018 Nov 28.

Guidelines for vitamin K prophylaxis in newborns.

Ng E, et al. Paediatr Child Health. 2018 Sep;23(6):394-402.

School, child care and camp exclusion policies for chickenpox: A rational approach.

Bridger NA. Paediatr Child Health. 2018 Sep;23(6):420-427.

4. Case reports

An 11-Month-Old Male With Acute-Onset Left-Sided Facial Paralysis.

Posa M, et al.Clin Pediatr (Phila). 2019 Mar 22:9922819837354.

A Lower-limb Skin Lesion in a 10-year-old Girl.

Koirala A, et al. Pediatr Infect Dis J. 2019 Apr;38(4):e79.

Exercise-Induced Purpura in Children.

Paul SS, et al.Pediatrics. 2019 Apr;143(4).

 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!

Please join us for our next #DFTB_JC on twitter…The DFTB/ADC Journal Club is a monthly collaboration between @DFTBubbles and @ADC_BMJ featuring a FREE access article from the latest issues of Archives of Disease of Childhood.

The 28th Bobble Wrap

Cite this article as:
Leo, G. The 28th Bobble Wrap, Don't Forget the Bubbles, 2019. Available at:
https://dontforgetthebubbles.com/the-28th-bobble-wrap/

With millions upon millions of journal articles being published every year it is impossible to keep up. Today, being the 1st of April, the Don’t Forget The Bubbles Team thought it best to celebrate laughter and humour in children and our hospitals. The formal Bubble Wrap for April will be released next week.

Bubble Wrap PLUS – February

Cite this article as:
Anke Raaijmakers. Bubble Wrap PLUS – February, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.18007

Welcome to February’s Bubble Wrap Plus, our monthly paediatric journal club provided by Professor Jaan Toelen & his team of the University Hospitals in Leuven (Belgium). This comprehensive list of ‘articles to read’ comes from 34 journals, including Pediatrics, The Journal of Pediatrics, Archives of Disease in Childhood, JAMA Pediatrics, Journal of Paediatrics and Child Health, NEJM, and many more.

This month’s list features answers to intriguing questions (and maybe answers) such as: ‘Is inattention the main cause of medication errors in hospitalized newborns?’, ‘Which children have trouble falling asleep after concussion?’, ‘What are the determinants of low measles vaccination coverage in children?’, ‘Is new media usage associated with poorer sleep in toddlers?’ and ‘Is early fish introduction associated with a lower risk of asthma?’.

You will find the list broken down into four sections:

1.Reviews and opinion articles

New therapies for acute RSV infections: where are we?

Xing Y, Proesmans M. Eur J Pediatr. 2019 Feb;178(2):131-138.

ADHD in children and youth: Part 1-Etiology, diagnosis, and comorbidity.

Bélanger SA, et al. Paediatr Child Health. 2018 Nov;23(7):447-453.

ADHD in children and youth: Part 2-Treatment.

Feldman ME, et al. Paediatr Child Health. 2018 Nov;23(7):462-472.

Imaging of diseases of the vagina and external genitalia in children.

Matos J, et al. Pediatr Radiol. 2019 Jan 5.

Supporting breathing of preterm infants at birth: a narrative review.

Martherus T, et al. Arch Dis Child Fetal Neonatal Ed. 2019 Jan;104(1):F102-F107.

2. Original clinical studies

Incident reports versus direct observation to identify medication errors and risk factors in hospitalised newborns.

Palmero D, et al. Eur J Pediatr. 2019 Feb;178(2):259-266.

Risk prediction of severe reaction to oral challenge test of cow’s milk.

Kawahara T, et al. Eur J Pediatr. 2019 Feb;178(2):181-188.

Association Between Screen Time and Children’s Performance on a Developmental Screening Test.

Madigan S, et al. JAMA Pediatr. 2019 Jan 28.

Presentation and outcomes in hypertrophic pyloric stenosis: An 11-year review.

Vinycomb TI, et al. J Paediatr Child Health. 2019 Jan 24.

Trouble Falling Asleep After Concussion Is Associated With Higher Symptom Burden Among Children and Adolescents.

Howell DR, et al. J Child Neurol. 2019 Jan 22:883073818824000.

Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial.

Schwimmer JB, et al. JAMA. 2019 Jan 22;321(3):256-265.

Association of Rotavirus Vaccination With the Incidence of Type 1 Diabetes in Children.

Perrett KP, et al. JAMA Pediatr. 2019 Jan 22.

Questions and Concerns About HPV Vaccine: A Communication Experiment.

Shah PD, et al. Pediatrics. 2019 Jan 22.

Three Important Findings From a Study on HPV “Real World” Effectiveness.

Dempsey AF. Pediatrics. 2019 Jan 22.

Human Papillomavirus Vaccine Effectiveness and Herd Protection in Young Women.

Spinner C, et al. Pediatrics. 2019 Jan 22.

High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis.

Lin J, et al. Arch Dis Child. 2019 Jan 17.

Determinants of low measles vaccination coverage in children living in an endemic area.

Lo Vecchio A, et al. Eur J Pediatr. 2019 Feb;178(2):243-251.

Factors Associated With Rotavirus Vaccine Coverage.

Aliabadi N, et al. Pediatrics. 2019 Jan 17.

Recognizing critically ill children with a modified pediatric early warning score at the emergency department, a feasibility study.

Vredebregt SJ, et al. Eur J Pediatr. 2019 Feb;178(2):229-234.

Calprotectin instability may lead to undertreatment in children with IBD.

Haisma SM, et al. Arch Dis Child. 2019 Jan 17.

Psychogenic movement disorders in children and adolescents: an update.

Harris SR. Eur J Pediatr. 2019 Jan 11.

Sleep and new media usage in toddlers.

Chindamo S, et al. Eur J Pediatr. 2019 Jan 16.

Preventing Neonatal Group B Streptococcus Disease: The Limits of Success.

Mukhopadhyay S, et al. JAMA Pediatr. 2019 Jan 14.

Epidemiology of Invasive Early-Onset and Late-Onset Group B Streptococcal Disease in the United States, 2006 to 2015: Multistate Laboratory and Population-Based Surveillance.

Nanduri SA, et al. JAMA Pediatr. 2019 Jan 14.

Complications and risk factors for severe outcome in children with measles.

Lo Vecchio A, et al. Arch Dis Child. 2019 Jan 12.

RSV hospitalization in infancy increases the risk of current wheeze at age 6 in late preterm born children without atopic predisposition.

Korsten K, et al. Eur J Pediatr. 2019 Jan 12.

Cognitive Outcomes and Positional Plagiocephaly.

Collett BR, et al. Pediatrics. 2019 Jan 11.

Retinal Findings in Young Children With Increased Intracranial Pressure From Nontraumatic Causes.

Shi A, et al. Pediatrics. 2019 Jan 10.

Introduction of fish and other foods during infancy and risk of asthma in the All Babies In Southeast Sweden cohort study.

Klingberg S, et al. Eur J Pediatr. 2019 Jan 7.

Nebulised hypertonic saline in children with bronchiolitis admitted to the paediatric intensive care unit: A retrospective study.

Stobbelaar K, et al. J Paediatr Child Health. 2019 Jan 6.

Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia.

Ryan RM, et al. J Pediatr. 2019 Jan 4.

Exposure to and use of mobile devices in children aged 1-60 months.

Kılıç AO, et al. Eur J Pediatr. 2019 Feb;178(2):221-227.

Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development.

Bandoli G, et al. Pediatrics. 2019 Jan 4.

Wide variation in severe neonatal morbidity among very preterm infants in European regions.

Edstedt Bonamy AK, et al. Arch Dis Child Fetal Neonatal Ed. 2019 Jan;104(1):F36-F45.

Follow-up and outcome of symptomatic partial or absolute IgA deficiency in children.

Moschese V, et al. Eur J Pediatr. 2019 Jan;178(1):51-60.

The problem of defecation disorders in children is underestimated and easily goes unrecognized: a cross-sectional study.

Timmerman MEW, et al. Eur J Pediatr. 2019 Jan;178(1):33-39.

Meningococcal Disease Among College-Aged Young Adults: 2014-2016.

Mbaeyi SA, et al. Pediatrics. 2019 Jan;143(1).

3. Guidelines and best evidence

Diagnosis and Management of Kawasaki Disease.

Sosa T, et al. JAMA Pediatr. 2019 Jan 22.

Pharmacologic Treatments for Sleep Disorders in Children: A Systematic Review.

McDonagh MS, et al. J Child Neurol. 2019 Jan 23:883073818821030.

Development and Validation of a Cellulitis Risk Score: The Melbourne ASSET Score.

Ibrahim LF, et al. Pediatrics. 2019 Jan 3.

Nasal high flow therapy for neonates: Current evidence and future directions.

Hodgson KA, et al. J Paediatr Child Health. 2019 Jan 7.

Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: US Preventive Services Task Force Reaffirmation Recommendation Statement.

US Preventive Services Task Force, Curry SJ, et al. JAMA. 2019 Jan 29;321(4):394-398.

4. Case reports

A Devil of a Case: Chest Pain in an Adolescent.

Bruehl MJ, et al. Clin Pediatr (Phila). 2019 Jan 28:9922819826102

 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!

Please join us for our next #DFTB_JC on twitter…The DFTB/ADC Journal Club is a monthly collaboration between @DFTBubbles and @ADC_BMJ featuring a FREE access article from the latest issues of Archives of Disease of Childhood. January’s pick  is ‘ Can we use POCUS to Diagnose Pneumonia?’ Read the article here: bit.ly/2TMDf2M The chat will happen on twitter at Tue 22/1/19 at UTC2000hrs (That’s Wednesday 0700 23/1 AEST), just search the hashtag #DFTB_JC

The 26th Bubble Wrap

Cite this article as:
Leo, G. The 26th Bubble Wrap, Don't Forget the Bubbles, 2019. Available at:
https://dontforgetthebubbles.com/26th-bubble-wrap/

With millions upon millions of journal articles being published every year it is impossible to keep up.  Every month we ask some of our friends from PERUKI (Paediatric Emergency Research in UK and Ireland) to point out something that has caught their eye.

This month to ease us into the new clinical year; this bubble wrap will featuring a couple of new papers but also a few flashback reviews of some papers we’ve explored in other posts in case you missed them the first time around!

Bubble Wrap PLUS – Dec 18 / Jan 19

Cite this article as:
Anke Raaijmakers. Bubble Wrap PLUS – Dec 18 / Jan 19, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.17802

Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list from Anke Raaijmakers working with Professor Jaan Toelen & his team of the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or simply help you to keep an finger on the pulse of paediatric research.

This bumper edition of Bubble Wrap Plus heralds the end of 2018 and a fresh start with 2019 to explore answers to intriguing questions such as: ‘Should children rest after mild traumatic brain injury?’, ‘Is US guided LP superior to standard technique?’, ‘Do we prescribe acid-suppression too often?’, ‘Does e-cigarette use lead to or prevent smoking in adolescents?’ and ‘Should we institute elective replacement of IV cannulas in neonates?’.

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Refeeding in anorexia nervosa.

Bargiacchi A, et al. Eur J Pediatr. 2018 Nov 27.

End-stage kidney disease in infancy: an educational review.

Sanderson KR, et al. Pediatr Nephrol. 2018 Nov 21.

Renal aspects of metabolic acid-base disorders in neonates.

Iacobelli S, et al. Pediatr Nephrol. 2018 Nov 19.

Pain Relief in the Palm of Your Hand: Harnessing Mobile Health to Manage Pediatric Pain.

Hunter JF, et al. Paediatr Anaesth. 2018 Nov 16.

Cerebral palsy: not always what it seems.

Appleton RE, et al. Arch Dis Child. 2018 Nov 9.

Utility of lung ultrasound scanning in neonatology.

Woods PL. Arch Dis Child. 2018 Nov 9.

Early warning scores in paediatrics: an overview.

Chapman SM, et al. Arch Dis Child. 2018 Nov 9.

A narrative review of proteinuria and albuminuria as clinical biomarkers in children.

Larkins NG, et al. J Paediatr Child Health. 2018 Nov 9.

A review of feeding intolerance in critically ill children.

Tume LN, et al. Eur J Pediatr. 2018 Nov;177(11):1675-1683.

Practical Wisdom, Rules, and the Parent-Pediatrician Conversation.

Brudney D. Pediatrics. 2018 Nov;142(Suppl 3):S193-S198.

Understanding and Improving Diagnostic Tests: The Clinician Perspective.

Ng PC. Neonatology. 2018 Dec 21;115(3):189-196

Developmental Dysplasia of the Hip.

Yang S, et al. Pediatrics. 2018 Dec 26.

An approach to the child with a wet cough.

Gilchrist FJ. Paediatr Respir Rev. 2018 Nov 23.

What’s new in autoinflammation?

Ozen S. Pediatr Nephrol. 2018 Dec 14

Antiemetic Drug Use in Children: What the Clinician Needs to Know.

Romano C, et al. J Pediatr Gastroenterol Nutr. 2018 Dec 11

The neuroimaging mimics of abusive head trauma.

Mankad K, et al. Eur J Paediatr Neurol. 2018 Nov 22.

How to give a better lecture.

Isaacs D, et al. J Paediatr Child Health. 2018 Dec;54(12):1290-1291

Circumcision in the Paediatric Patient: A Review of Indications, Technique and Complications.

Sebaratnam DF. J Paediatr Child Health. 2018 Dec;54(12):1404.

Magnetic resonance imaging of the pediatric mediastinum.

Bardo DME, et al. Pediatr Radiol. 2018 Aug;48(9):1209-1222

Whole-body magnetic resonance imaging: techniques and non-oncologic indications.

Greer MC. Pediatr Radiol. 2018 Aug;48(9):1348-1363.

Neuropathological Developments in Sudden Infant Death Syndrome.

Bright FM, et al. Pediatr Dev Pathol. 2018 Nov-Dec;21(6):515-521.

Hypersensitivity reactions to intravenous antibiotics in cystic fibrosis.

Wright MFA, et al. Paediatr Respir Rev. 2018 Jun;27:9-12.

Understanding cardiac shunts.

Joffe DC, et al. Paediatr Anaesth. 2018 Apr;28(4):316-325.

Vaccination in Pregnancy-Recent Developments.

Jones CE, et al. Pediatr Infect Dis J. 2018 Feb;37(2):191-193.

2. Original clinical studies

Risk Stratification of Febrile Infants ≤60 Days Old Without Routine Lumbar Puncture.

Aronson PL, et al. Pediatrics. 2018 Nov 13.

Omission of Lumbar Puncture From Evaluation of Source of Fever in Young Infants.

Baker MD. Pediatrics. 2018 Nov 13.

Drowsy Driving, Sleep Duration, and Chronotype in Adolescents.

Owens JA, et al. J Pediatr. 2018 Nov 2.

The mediating role of sleep in the relationship between Indigenous status and body mass index in Australian school-aged children.

Deacon-Crouch M, et al. J Paediatr Child Health. 2018 Nov 24.

Cardiovascular Autonomic Control Is Altered in Children Born Preterm with Sleep Disordered Breathing.

Thomas B, et al. J Pediatr. 2018 Nov 13.

Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea.

Oliveira FMS, et al. Pediatr Res. 2018 Nov 12.

Does Sleep Matter? Impact on Development and Functioning in Infants.

Mindell JA, et al. Pediatrics. 2018 Nov 12.

Uninterrupted Infant Sleep, Development, and Maternal Mood.

Pennestri MH, et al. Pediatrics. 2018 Nov 12.

Development of sleep patterns in children with obese and normal-weight parents.

Xiu L, et al. J Paediatr Child Health. 2018 Nov 10.

Digital Screen Time and Pediatric Sleep: Evidence from a Preregistered Cohort Study.

Przybylski AK. J Pediatr. 2018 Oct 30.

Non-indicated acid-suppression prescribing in a tertiary paediatric hospital: An audit and costing study.

Riess S, et al. J Paediatr Child Health. 2018 Nov 28.

Screening for Iron Deficiency in Early Childhood Using Serum Ferritin in the Primary Care Setting.

Oatley H, et al. Pediatrics. 2018 Nov 28.

Staff matter too: pilot staff support intervention to reduce stress and burn-out on a neonatal intensive care unit.

D’Urso A, et al. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 26.

Being Overweight or Obese and the Development of Asthma.

Lang JE, et al. Pediatrics. 2018 Nov 26.

Language in 2-year-old children born preterm and term: a cohort study.

Sanchez K, et al. Arch Dis Child. 2018 Nov 23.

Association between exposure to macrolides and the development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis.

Abdellatif M, et al. Eur J Pediatr. 2018 Nov 23.

Towards an individual screening strategy for first-degree relatives of celiac patients.

Wessels MMS, et al. Eur J Pediatr. 2018 Nov;177(11):1585-1592.

Randomised cross-over study of automated oxygen control for preterm infants receiving nasal high flow.

Reynolds PR, et al. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 21.

Comparison of a Smartphone Otoscope and Conventional Otoscope in the Diagnosis and Management of Acute Otitis Media.

Chan KN, et al. Clin Pediatr (Phila). 2018 Nov 21:

Association of Prenatal Exposure to Air Pollution With Autism Spectrum Disorder.

Pagalan L, et al. JAMA Pediatr. 2018 Nov 19.

Efficacy of Lactobacillus-supplemented triple therapy for Helicobacter pylori infection in children: a meta-analysis of randomized controlled trials.

Fang HR, et al. Eur J Pediatr. 2018 Nov 16.

Trends and Predictors of Clostridium difficile Infection among Children: A Canadian Population-Based Study.

El-Matary W, et al. J Pediatr. 2018 Nov 15.

A comparison between the feeding practices of parents and grandparents.

Metbulut AP, et al. Eur J Pediatr. 2018 Dec;177(12):1785-1794.

Assessment of clinical outcome of children with sepsis outside the intensive care unit.

Zallocco F, et al. Eur J Pediatr. 2018 Dec;177(12):1775-1783.

Pediatric residents’ simulation-based training in patient safety during sedation.

Friedman N, et al. Eur J Pediatr. 2018 Dec;177(12):1863-1867.

Association Between Obesity/Overweight and Functional Gastrointestinal Disorders in Children.

Tambucci R, et al. J Pediatr Gastroenterol Nutr. 2018 Nov 15.

Exposure to and use of mobile devices in children aged 1-60 months.

Kılıç AO, et al. Eur J Pediatr. 2018 Nov 6.

Adenovirus-Associated Central Nervous System Disease in Children.

Schwartz KL, et al. J Pediatr. 2018 Nov 6.

Intellectual Disability in Children Conceived Using Assisted Reproductive Technology.

Hansen M, et al. Pediatrics. 2018 Nov 15.

Physiological Effect of Prone Position in Children with Severe Bronchiolitis: A Randomized Cross-Over Study (BRONCHIO-DV).

Baudin F, et al. J Pediatr. 2018 Nov 14.

Influence of Fathers’ Early Parenting on the Development of Children Born Very Preterm and Full Term.

McMahon GE, et al. J Pediatr. 2018 Nov 14.

Clinical recovery in children with uncomplicated appendicitis undergoing non-operative treatment: secondary analysis of a prospective cohort study.

Knaapen M, et al. vEur J Pediatr. 2018 Nov 12.

Maternal obesity and offspring cognition: the role of inflammation.

Monthé-Drèze C, et al. Pediatr Res. 2018 Nov 12.

Child BMI Over Time and Parent-Perceived Overweight.

Wake M, et al. Pediatrics. 2018 Nov 8.

Geographic and socioeconomic predictors of perforated appendicitis: A national Canadian cohort study.

Akhtar-Danesh GG, et al. J Pediatr Surg. 2018 Nov 7.

E-cigarette Use and Subsequent Smoking Frequency Among Adolescents.

Barrington-Trimis JL, et al. Pediatrics. 2018 Nov 5.

Elective replacement of intravenous cannula in neonates-a randomised trial.

Chin LY, et al. Eur J Pediatr. 2018 Nov;177(11):1719-1726.

Are adolescents really being sedentary or inactive when at school? An analysis of sedentary behaviour and physical activity bouts.

da Costa BGG, et al. Eur J Pediatr. 2018 Nov;177(11):1705-1710.

Delivery Room Management of Meconium-Stained Newborns and Respiratory Support.

Chiruvolu A, et al. Pediatrics. 2018 Nov 1.

Appropriate Management of the Nonvigorous Meconium-Stained Neonate: An Unanswered Question.

Wiswell TE. Pediatrics. 2018 Nov 1.

Gestational Age, Health, and Educational Outcomes in Adolescents.

Berry MJ, et al. Pediatrics. 2018 Nov;142(5).

PEG 3350 Versus Lactulose for Treatment of Functional Constipation in Children: Randomized Study.

Jarzębicka D, et al. J Pediatr Gastroenterol Nutr. 2018 Oct 31.

Nuchal Rigidity in Infantile Bacterial Meningitis.

Iio K, et al. J Pediatr. 2018 Oct 30.

Effect of synbiotic supplementation on children with atopic dermatitis: an observational prospective study.

Ibáñez MD, et al. Eur J Pediatr. 2018 Dec;177(12):1851-1858.

Mealtime insulin bolus adherence and glycemic control in adolescents on insulin pump therapy.

Spaans E, et al. Eur J Pediatr. 2018 Dec;177(12):1831-1836.

Performance of Tuberculin Skin Tests and Interferon-γ Release Assays in Children Younger Than 5 Years.

Velasco-Arnaiz E, et al. Pediatr Infect Dis J. 2018 Dec;37(12):1235-1241.

Viral Acute Respiratory Illnesses in Young Infants Increase the Risk of Respiratory Readmission.

Toizumi M, et al. Pediatr Infect Dis J. 2018 Dec;37(12):1217-1222.

Psychosocial functioning of parents of children with heart disease-describing the landscape.

Wray J, et al. Eur J Pediatr. 2018 Dec;177(12):1811-1821.

Changes in bilirubin in infants with hypoxic-ischemic encephalopathy.

Dani C, et al. Eur J Pediatr. 2018 Dec;177(12):1795-1801.

Needle-related pain and distress management during needle-related procedures in children with and without intellectual disability.

Pascolo P, et al. Eur J Pediatr. 2018 Dec;177(12):1753-1760.

Parent experience in the resuscitation room: how do they feel?

Parra C, et al. Eur J Pediatr. 2018 Dec;177(12):1859-1862.

Renal Replacement Therapy in children with severe developmental disability: guiding questions for decision-making.

Willem L, et al. Eur J Pediatr. 2018 Dec;177(12):1735-1743.

Human Parechovirus 1, 3 and 4 Neutralizing Antibodies in Dutch Mothers and Infants and Their Role in Protection Against Disease.

Karelehto E, et al. Pediatr Infect Dis J. 2018 Dec;37(12):1304-1308.

Predictors of grade 3-5 vesicoureteral reflux in infants ≤ 2 months of age with pyelonephritis.

Bahat H, et al. Pediatr Nephrol. 2018 Dec 26.

Prospective associations between television in the preschool bedroom and later bio-psycho-social risks.

Pagani LS, et al. Pediatr Res. 2018 Dec 26.

Trends, Safety, and Recommendations for Caffeine Use in Children and Adolescents.

Temple JL. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):36-45

Efficacy and Safety of EMLA Cream for Pain Control Due to Venipuncture in Infants: A Meta-analysis.

Shahid S, et al. Pediatrics. 2018 Dec 26.

Age-Related Changes in Inferior Vena Cava Dimensions among Children and Adolescent with Syncope.

Shivaram P, et al. J Pediatr. 2018 Dec 21.

Tracing Effects of Parental Discipline on Child Psychopathology: The Devil’s in the Detail.

Wertz J. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):20-21

Disciplinary Parenting Practice and Child Mental Health: Evidence From the UK MillenniumCohort Study.

Rajyaguru P, et al. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):108-116.e2

Clinical Manifestations, Management, and Outcomes of Osteitis/Osteomyelitis Caused by Mycobacterium bovis Bacillus Calmette-Guérin in Children: Comparison by Site(s) of Affected Bones.

Huang CY, et al. J Pediatr. 2018 Dec 18.

Eating disorder or disordered eating: undiagnosed inflammatory bowel disease mimicking eating disorder.

Harris RE, et al. Arch Dis Child. 2018 Dec 19

Cofactors of Pediatric Tinnitus: A Look at the Whole Picture.

Levi J, Basa K, et al. Clin Pediatr (Phila). 2018 Dec 3:9922818816426.

Probing the Irritability-Suicidality Nexus.

Stringaris A, et al. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):18-19.

Pathways of Association Between Childhood Irritability and Adolescent Suicidality.

Orri M, et al. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):99-107.e3.

Non-urgent paediatric emergency department presentation: A systematic review.

Alele FO, et al. J Paediatr Child Health. 2018 Dec 20.

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

Rice GI, et al. N Engl J Med. 2018 Dec 6;379(23):2275-7.

Everything is awesome: Don’t forget the Lego.

Tagg A, et al. J Paediatr Child Health. 2018 Nov 22.

Oral dextrose gel to treat neonatal hypoglycaemia: Clinician survey.

Alsweiler JM, et al. J Paediatr Child Health. 2018 Nov 22.

Symptoms of Feeding Problems in Preterm-born Children at 6 Months to 7 years Old.

Park J, et al. J Pediatr Gastroenterol Nutr. 2018 Dec 14

Physical activity after mild traumatic brain injury: What are the relationships with fatigue and sleep quality?

van Markus-Doornbosch F, et al. Eur J Paediatr Neurol. 2018 Nov 14

Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile.

Chen LA, et al. J Pediatr Gastroenterol Nutr. 2018 Dec 11.

Comparison of Antibiotic Prescribing for Pediatric Community-Acquired Pneumonia in Children’s and Non-Children’s Hospitals.

Tribble AC, et al. JAMA Pediatr. 2018 Dec 10

Severe Respiratory Syncytial Virus Infection in Hospitalized Children Less Than 3 Years of Age in a Temperate and Tropical Climate.

Butler J, et al. Pediatr Infect Dis J. 2019 Jan;38(1):6-11.

Safety of Lactobacillus reuteri DSM 17938 in Healthy Children 2 to 5 Years of Age.

Kosek MN, et al. Pediatr Infect Dis J. 2018 Dec 10.

Antibiotics for urethral catheterization in children undergoing cystography: retrospective evaluation of a single-center cohort of pediatric non-toilet-trained patients.

Marzuillo P, et al. Eur J Pediatr. 2018 Dec 1.

Yield of brain imaging among neurologically normal children with headache on wakening or headache waking the patient from sleep.

Ahmed MAS, et al. Eur J Paediatr Neurol. 2018 Sep;22(5):797-802.

Paediatricians’ attitudes to and management of functional seizures in children.

Nielsen ES, et al. Eur J Paediatr Neurol. 2018 Sep;22(5):774-781.

Ultrasound-guided lumbar puncture in pediatric patients: technical success and safety.

Pierce DB, et al. Pediatr Radiol. 2018 Jun;48(6):875-881.

Does vitamin E prevent asthma or wheeze in children: A systematic review and meta-analysis.

Wu H, et al. Paediatr Respir Rev. 2018 Jun;27:60-68.

Evaluation of the Clinical Utility of a Real-time PCR Assay for the Diagnosis of Streptococcus pneumoniae Bacteremia in Children: A Retrospective Diagnostic Accuracy Study.

Murphy J, et al. Pediatr Infect Dis J. 2018 Feb;37(2):153-156.

Urinary Tract Infection in Children With Nephrotic Syndrome.

Narain U, et al. Pediatr Infect Dis J. 2018 Feb;37(2):144-146.

Safety of Outpatient Parenteral Antimicrobial Therapy in Children.

Fernandes P, et al. Pediatr Infect Dis J. 2018 Feb;37(2):157-163.

Epidemiology of Sepsis-like Illness in Young Infants: Major Role of Enterovirus and Human Parechovirus.

de Jong EP, et al. Pediatr Infect Dis J. 2018 Feb;37(2):113-118.

3. Guidelines and best evidence

Clinical Practice Guideline: Maintenance Intravenous Fluids in Children.

Feld LG, et al. Pediatrics. 2018 Nov 26.

Management of severe bronchiolitis: impact of NICE guidelines.

Griffiths B, et al. Arch Dis Child. 2018 Nov 24.

Which vasoactive drug should be first choice in paediatric septic shock?

McVea S, et al. Arch Dis Child. 2018 Nov 9.

Effective Discipline to Raise Healthy Children.

Sege RD, et al. Pediatrics. 2018 Nov 5.

Clinical Practice Guideline for the Management of Infantile Hemangiomas.

Krowchuk DP, et al. Pediatrics. 2018 Dec 24

Initial Oxygen Use for Preterm Newborn Resuscitation: A Systematic Review With Meta-analysis.

Welsford M, et al. Pediatrics. 2018 Dec 21

Room Air for Initiating Term Newborn Resuscitation: A Systematic Review With Meta-analysis.

Welsford M, et al. Pediatrics. 2018 Dec 21

Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER).

Hoofien A, et al. J Pediatr Gastroenterol Nutr. 2018 Dec 11.

Question 3: Can we diagnose asthma in children under the age of 5 years?

Yang CL, et al. Paediatr Respir Rev. 2018 Oct 24.

Why should we screen for arterial hypertension in children and adolescents?

Litwin M. Pediatr Nephrol. 2018 Jan;33(1):83-92.

Screening children for hypertension: the case against.

Ide N, et al. Pediatr Nephrol. 2018 Jan;33(1):93-100.

To screen or not to screen: for high blood pressure.

Tullus K. Pediatr Nephrol. 2018 Jan;33(1):81-82.

Interventions to Improve Medication Adherence: A Review.

Kini V, et al. JAMA. 2018 Dec 18;320(23):2461-2473.

4. Case reports

Rare and striking complication of Henoch-Schönlein purpura.

Moussaoui D, et al. Arch Dis Child. 2018 Nov 23.

Young girl with bruising: Finding the X factor.

Chan DW, et al. J Paediatr Child Health. 2018 Nov 13.

Case 19-2018: A 15-Year-Old Girl with Acute Kidney Injury.

Grisaru S, et al. N Engl J Med. 2018 Nov 1;379(18):e34.

Dissociative state: Returned traveller with a high fever and low heart rate.

Freeth P, et al. J Paediatr Child Health. 2018 Dec;54(12):1395-1396.

Acute Knee Swelling and Limp in a 10-year-old Child.

Islam S, et al. Pediatr Infect Dis J. 2018 Feb;37(2):194-195.

 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!

Please join us for our next #DFTB_JC on twitter…The DFTB/ADC Journal Club is a monthly collaboration between @DFTBubbles and @ADC_BMJ featuring a FREE access article from the latest issues of Archives of Disease of Childhood. January’s pick  is ‘ Can we use POCUS to Diagnose Pneumonia?’ Read the article here: bit.ly/2TMDf2M The chat will happen on twitter at Tue 22/1/19 at UTC2000hrs (That’s Wednesday 0700 23/1 AEST), just search the hashtag #DFTB_JC

The 25th Bubble Wrap [Holiday Edition]

Cite this article as:
Leo, G. The 25th Bubble Wrap [Holiday Edition], Don't Forget the Bubbles, 2018. Available at:
https://dontforgetthebubbles.com/the-25th-bubble-wrap/

With millions upon millions of journal articles being published every year it is impossible to keep up.  Every month we ask some of our friends from PERUKI (Paediatric Emergency Research in UK and Ireland) to point out something that has caught their eye.