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Bubble Wrap PLUS – December 23


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly Paediatric Journal Club reading list from Professor Jaan Toelen (University Hospitals Leuven) and Dr Anke Raaijmakers (Sydney Children’s Hospital). 

This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research.

When you read medical articles to stay up-to-date, you may not know certain studies pique your interest more than others. It could be because an original or intriguing research question has been answered, or because it was published in a top journal, or written by an author you once met at a conference. As we perused the articles from this month’s journal club list, some pieces ‘entrenched’ themselves more firmly in our minds.

Prevention is often a very economical but potent form of medicine. In the current issue of the Journal of the American Academy of Child and Adolescent Psychiatry, Sandler and colleagues report on the long-term effects of a family bereavement program (FBP). This study involved an intervention to promote resilience among children or adolescents who lost a parent. Assessing the impact 15 years later, individuals who received the intervention exhibited half the rate of depression compared to those in the comparison group (13.46% vs. 28.05%). What makes this noteworthy? This effect is not only larger but also more enduring than many evidence-based treatments for depression.

In the current issue of Pediatrics, Ten Kate and colleagues conducted a meta-analysis on the accuracy of transcutaneous bilirubin (TcB) before, during, and after phototherapy. While TcB is a valid screening tool for identifying neonates requiring measurement of total serum bilirubin (TSB) before phototherapy, its value during and after the treatment remains uncertain. The meta-analysis suggests that TcB measurements before and during phototherapy on covered skin exhibit good agreement with TSB in both term and preterm newborns. However, more studies are needed to evaluate its accuracy after phototherapy.

Gutman and colleagues, in their publication in JAMA Pediatrics, delved into a question many ponder. We know that febrile infants, at low risk of invasive bacterial infections, are unlikely to benefit from lumbar puncture, antibiotics, or hospitalization, yet we commonly perform these procedures. Their study explored associations between race, ethnicity, language, and additional interventions in the U.S. healthcare setting. They concluded that, in low-risk, febrile infants, the language used for medical care was associated with the use of at least one non-indicated intervention, whereas race and ethnicity were not. Differences in language may create communication barriers, fostering disparities in medical care.

Adolescent medicine is often considered a branch of paediatrics where many paediatricians feel uneasy due to the behavioural issues, psychological problems, and eating disorders of their patients.  Yet those of us who frequently care for adolescents can attest that they are thankful patients when they feel you take them seriously. In the Lancet, Vrinten and colleagues examined the use of social media among children and young people and its associations with health behaviours. Their analyses revealed an association between social media use and e-cigarette and tobacco use. Unravelling the causal relationship is challenging, but it’s conceivable that some of these products are promoted on social media by influencers or through advertisements. This study adds to the growing list of negative aspects of social media use in adolescence. Alsarrani and colleagues, who also published in the Lancet, focused on adolescents living in Northern Ireland. Recognizing that friendships play a vital role in the social lives of teenagers, this study found that friendship quality was significantly associated with mood, psychological well-being, and subjective well-being in adolescents. Future research should incorporate longitudinal analyses to test these associations robustly.

1.Reviews and opinion articles

Dental caries in children and vitamin D deficiency: a narrative review. 

Durá-Travé T, Gallinas-Victoriano F. Eur J Pediatr. 2023 Nov 15. 

The Role of Medical Education Podcasts in Pediatrics. 

Parga-Belinkie JJ, et al. Pediatrics. 2023 Nov 1;152(5):e2023062911. 

Preventing Excessive Noise Exposure in Infants, Children, and Adolescents. 

Balk SJ, et al. Pediatrics. 2023 Nov 1;152(5):e2023063753. 

Updates in Food Allergy Prevention in Children. 

Abrams EM, et al. Pediatrics. 2023 Nov 1;152(5):e2023062836. 

Gut microbiota and neonatal acute kidney injury biomarkers. 

Yang K, et al. Pediatr Nephrol. 2023 Nov;38(11):3529-3547. 

Near-fatal and fatal asthma and air pollution: are we missing an opportunity to ask key questions? 

Varghese D, et al. Arch Dis Child. 2023 Nov 10:archdischild-2023-325548. 

From premature birth to premature kidney disease: does accelerated aging play a role? Sanderson KR, et al. Pediatr Nephrol. 2023 Nov 10.

2.Original clinical studies

Caregiver knowledge and attitudes relating to paediatric pneumonia and antimicrobial stewardship: a qualitative study. 

Huang N, et al. Arch Dis Child. 2023 Nov 28:archdischild-2023-326080. 

Period prevalence of positional head deformations and implications for practice in a large tertiary neonatal unit. 

Hepnar L, et al. J Paediatr Child Health. 2023 Nov 27. 

Risk Factors for Admission Hyperthermia and Associated Outcomes in Preterm Infants. 

Chiu M, et al. J Pediatr. 2023 Nov 21:113842. 

Hearing impairment after asphyxia and neonatal encephalopathy: a Norwegian population-based study. 

Hemmingsen D, et al. Eur J Pediatr. 2023 Nov 22. 

Transcutaneous Bilirubin Accuracy Before, During, and After Phototherapy: A Meta-Analysis. 

Ten Kate L, et al. Pediatrics. 2023 Nov 22:e2023062335. 

A reappraisal of risk factors for hypertension after pediatric acute kidney injury. 

Patel M, et al. Pediatr Nephrol. 2023 Nov 21. 

Rare De Novo and Inherited Genes in Familial and Nonfamilial Pediatric Attention-Deficit/Hyperactivity Disorder. 

Arnett AB, et al. JAMA Pediatr. 2023 Nov 20:e234952. 

High-Dose Docosahexaenoic Acid in Newborns Born at Less Than 29 Weeks’ Gestation and Behavior at Age 5 Years: Follow-Up of a Randomized Clinical Trial. 

Gould JF, et al. JAMA Pediatr. 2023 Nov 20:e234924. 

Steps per day and health-related quality of life in schoolchildren: the mediator role of cardiorespiratory fitness. 

Rodríguez-Gutiérrez E et al. Eur J Pediatr. 2023 Nov 18. 

Cow’s Milk-related Symptom Score (CoMiSS) values in presumed healthy European infants aged 6-12 months: a cross-sectional study. 

Jankiewicz M et al. Eur J Pediatr. 2023 Nov 17. 

Caregiver Language Preference and Health Care Utilization Among Children With Asthma. 

Emmanuel M, et al. Pediatrics. 2023 Nov 15:e2023061869. 

Does multiple gastric aspirate collection increase sensitivity of M. tuberculosis detection in children with pulmonary tuberculosis? 

Venturini E, et al.Eur J Pediatr. 2023 Nov 4. 

The initial angle of the maximum expiratory flow-volume curve: a novel start-of-test criteria of spirometry in children. 

Yao L, et al. Eur J Pediatr. 2023 Nov 4. 

Rehydration Rates and Outcomes in Overweight Children With Diabetic Ketoacidosis. 

Brown KM, et al. Pediatrics. 2023 Nov 3:e2023062004. 

A Quality Improvement Initiative to Reduce Necrotizing Enterocolitis in Very Preterm Infants. 

Alshaikh BN, et al. Pediatrics. 2023 Nov 3:e2023061273. 

Children’s scabies survey indicates high prevalence and misdiagnosis in Auckland educational institutions. 

Thornley S, et al. J Paediatr Child Health. 2023 Nov 2. 

Hospital discharge using salbutamol as required after acute attacks of wheeze in children: a service evaluation. 

Connett G, et al. Arch Dis Child. 2023 Nov 2:archdischild-2023-325703. 

COVID-19 pandemic and language development in children at 18 months: a repeated cross-sectional study over a 6-year period in Japan. 

Matsuo R, et al. Arch Dis Child. 2023 Nov 2:archdischild-2023-325926. 

Evaluation of endothelial dysfunction in hypertensive children and adolescents. 

Doğan K, et al. Pediatr Nephrol. 2023 Nov 2. PMID: 37914964 

Mental Health of Youth With Autism Spectrum Disorder and Gender Dysphoria. 

Kahn NF, et al. Pediatrics. 2023 Nov 1:e2023063289. PMID: 37909059 

Maternal Pertussis Vaccination, Infant Immunization, and Risk of Pertussis. 

Regan AK, et al. Pediatrics. 2023 Nov 1;152(5):e2023062664. 

Impact of Vaccination During Pregnancy on Infant Pertussis Disease. 

Edwards KM. Pediatrics. 2023 Nov 1;152(5):e2023063067. 

Fatigue and Physical Activity Patterns in Children With Inflammatory Bowel Disease. 

Bevers N, et al. J Pediatr Gastroenterol Nutr. 2023 Nov 1;77(5):628-633. 

Developmental Pathways of the Family Bereavement Program to Prevent Major Depression 15 Years Later. 

Sandler I, et al. Child Adolesc Psychiatry. 2023 Nov;62(11):1233-1244. 

Editorial: Prevention’s Power: Depression Incidence Halved 15 Years After Participation in the Family Bereavement Program. 

Brent DA, Melhem NM. J Am Acad Child Adolesc Psychiatry. 2023 Nov;62(11):1191-1193. 

Do Adolescents Like School-Based Mindfulness Training? Predictors of Mindfulness Practice and Responsiveness in the MYRIAD Trial. 

Montero-Marin J, et al. J Am Acad Child Adolesc Psychiatry. 2023 Nov;62(11):1256-1269. 

Race, Ethnicity, Language, and the Treatment of Low-Risk Febrile Infants. 

Gutman CK, et al. JAMA Pediatr. 2023 Nov 13. 

Neurodevelopment at 24 months corrected age in extremely preterm infants treated with dexamethasone alternatives during the late postnatal period: a cohort study. 

Melan N, et al. Eur J Pediatr. 2023 Nov 13. 

Umbilical Cord Milking Versus Delayed Cord Clamping in Infants 28 to 32 Weeks: A Randomized Trial. 

Katheria A, et al. Pediatrics. 2023 Nov 9:e2023063113. 

Implementation feasibility of animal-assisted therapy in a pediatric intensive care unit: effectiveness on reduction of pain, fear, and anxiety. 

López-Fernández E, et al. Eur J Pediatr. 2023 Nov 8. 

Cardiac involvement and its clinical significance in patients with anorexia nervosa. 

Jomah S, et al. Eur J Pediatr. 2023 Nov 7. 

Predicting long-term neurocognitive outcome after pediatric intensive care unit admission for bronchiolitis-preliminary exploration of the potential of machine learning. 

de Sonnaville ESV, et al. Eur J Pediatr. 2023 Nov 6. 

Associations of social media use with smoking and e-cigarettes: a national longitudinal study. 

Vrinten C, et al. Lancet. 2023 Nov;402 Suppl 1:S91. 

Associations between parental smoking and teenage alcohol and drug use in the Growing Up in Ireland cohort study: a longitudinal observational study. 

Sunday S, et al. Lancet. 2023 Nov;402 Suppl 1:S89. 

Odds of gambling among adolescents: a secondary analysis of the cross-sectional European School Survey Project on Alcohol and Other Drugs. 

Reynolds CME, et al. Lancet. 2023 Nov;402 Suppl 1:S79. 

A peer-led walking intervention for adolescent girls (the WISH study): a cluster-randomised controlled trial. 

Murphy MH, et al. Lancet. 2023 Nov;402 Suppl 1:S72. 

Association between friendship quality and subjective wellbeing in adolescents: a cross-sectional observational study. Alsarrani A, et al. Lancet. 2023 Nov;402 Suppl 1:S21.

4.Case reports

Tale of a chest radiograph in Takayasu’s arteritis. 

Punnen AK, et al. Arch Dis Child. 2023 Nov 28:archdischild-2023-326334. 

Laryngeal Tuberculosis in a 7-year-old Child: A Case Report and Literature Review. 

Siddiqui MJ, et al. Pediatr Infect Dis J. 2023 Nov 27. 

Acute Switchitis: A New Subtype of Nintendinitis. 

Takahashi H, et al. J Pediatr. 2023 Nov 23:113852. 

Green Urine in the Diaper: A Key Indicator for Diagnosing Hemolytic Anemia. 

Yaguchi A, et al. J Pediatr. 2023 Nov 23:113856. 

Ukrainian War Refugee Children With Particularly Severe Viral Infections: A Case Series Report. 

Pluta M, et al. Pediatr Infect Dis J. 2023 Nov 1. 

A Rare Case of Rat Bite Fever in an 8-Month-old Girl. 

Meyer S, et al. Pediatr Infect Dis J. 2023 Nov 1;42(11):e430. 

Gonococcal Conjunctivitis in a 10-Year-old: Indication of Sexual Abuse? 

Lopes C, et al. Pediatr Infect Dis J. 2023 Nov 1;42(11):e425-e426. 

Is shorter antibiotic treatment duration increasing the risk of relapse in paediatric acute focal bacterial nephritis? 

Vaezipour N, et al. Arch Dis Child. 2023 Nov 10:archdischild-2023-326054. 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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