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Bubble Wrap PLUS – November 2023


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric Journal Club reading list from Professor Jaan Toelen (University Hospitals Leuven) and Dr Anke Raaijmakers (Sydney Children’s Hospital). 

This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research.

What are some of this month’s highlights?

Physicians often use proton pump inhibitors (PPIs) to treat infants with GER as it is often considered
a ‘safe treatment option’. Yet more and more studies show that this habit may not be without risks. In JAMA Pediatrics, Lassalle and colleagues studied the association between PPI use and the risk of serious infections (requiring hospitalization) in young children. They analysed the French National Health Insurance registry of all pregnancies and births from 2010 to 2018. They found that there was an increased risk of hospitalization in children who had had a PPI (with adjusted hazard ratios between 1.34 and 1.56). Even though exploring causality is impossible in such a methodology, the authors hypothesize several mechanistic explanations ranging from aspirations of bacteriologically contaminated gastric fluid to changes in the GI microbiome.

In another impressive study in the same journal, Jensen and colleagues published a population-based, case-control study of paediatric eosinophilic esophagitis (EoE) in Denmark (including all EoE cases among Danish residents born between 1997 and 2018). They identified 392 cases and selected 3637 sex- and year-of-birth-matched controls. Maternal and infant antibiotic use was associated with an increased risk of developing EoE in a dose-response manner, and the magnitude of association was highest for exposure near the time of delivery.

In the Pediatric Infectious Disease Journal, Guo and colleagues assessed the difference in clinical characteristics between viral pneumonia and Mycoplasma pneumoniae in a large Chinese cohort. They retrospectively identified 375 children with community-acquired pneumonia. Based on their findings, they developed a web-based, dynamic nomogram calculator. After inputting several clinical and biochemical characteristics, you can calculate the probability that the child has a Mycoplasma infection.

Vasovagal syncope (VVS) is a common type of syncope in paediatric practice. It can present in three ways: VVS-vaso-inhibited (decrease in BP alone), VVS-cardio-inhibited (decrease in HR alone) and VVS-mixed. In the European Journal of Pediatrics, Wang and colleagues studied 2513 patients between 3-18 years of age who presented with vasovagal syncope. Using a TILT test, they found that VVS-CI and VVS-M had a 203% and 175% increased likeliness, respectively, compared to VVS-VI. A study in Nature this week identified neural pathways, namely a subset of the vagal sensory neurons that connect the heart and the brain (NPY2R fibres), that induce syncope upon stimulation in mice. This provides an animal model for further study.

1.Reviews and opinion articles

An update on the role of fluid overload in the prediction of outcome in acute kidney injury.

Gorga SM, et al. Pediatr Nephrol. 2023 Oct 20. 

AI as a Mental Health Therapist for Adolescents.

Opel DJ, et al. JAMA Pediatr. 2023 Oct 16. 

Artificial Intelligence in Mental Health Therapy for Children and Adolescents.

Vial T, et al. JAMA Pediatr. 2023 Oct 16.

Evaluation and management of enuresis in the general paediatric setting.

Harris J, et al. Paediatr Child Health. 2023 Sep 23. 

Rosacea in children: a review.

Chiriac A, et al. Eur J Pediatr. 2023 Oct. 

2.Original clinical studies

2% chlorhexidine gluconate aqueous versus 2% chlorhexidine gluconate in 70% isopropyl alcohol for skin disinfection prior to percutaneous central venous catheterisation: the ARCTIC randomised controlled feasibility trial.

Clarke P, et al. Arch Dis Child Fetal Neonatal Ed. 2023 Oct 31. 

Composition and dynamics of intestinal fungi during the postnatal 2 months of very low birth weight infants.

Wang T, et al. Eur J Pediatr. 2023 Oct 31.

Use of healthcare services before diagnosis of attention-deficit/hyperactivity disorder: a population-based matched case-control study.

Prasad V, et al. Arch Dis Child. 2023 Oct 30. 

Maternal and Infant Antibiotic and Acid Suppressant Use and Risk of Eosinophilic Esophagitis.

Jensen ET, et al. JAMA Pediatr. 2023 Oct 30. 

Xylitol for the prevention of acute otitis media episodes in children aged 1-5 years: a randomised controlled trial.

Persaud N, et al. Arch Dis Child. 2023 Oct 27.

Parental physical disease severity and severe documented physical child abuse: a prospective cohort study.

Græsholt-Knudsen T, et al. Eur J Pediatr. 2023 Oct 27. 

Macronutrient content of pasteurised donor human milk: Variability between batches from single-donor pools at an Australian milk bank.

Walter L, et al. J Paediatr Child Health. 2023 Oct 25.

Accuracy of liquid drug dose measurements using different tools by caregivers: a prospective observational study.

Balıkçı BB, et al. Eur J Pediatr. 2023 Oct 25. 

Bacterial coinfection in young febrile infants with SARS-CoV-2 infection.

Hernández-Bou S, et al. Eur J Pediatr. 2023 Oct 23. 

Safety and Benefits of COVID-19 Vaccination in Pregnancy-Implications for the Maternal Vaccination Platform.

Healy CM, et al. JAMA Pediatr. 2023 Oct 23. 

Newborn and Early Infant Outcomes Following Maternal COVID-19 Vaccination During Pregnancy.

Jorgensen SCJ, et al. JAMA Pediatr. 2023 Oct 23. 

Hospital Admissions for Abusive Head Trauma Before and During the COVID-19 Pandemic.

Maassel NL, et al. JAMA Pediatr. 2023 Oct 23. 

Maternal beliefs and cognitions about naps in infants and toddlers.

Mindell JA, et al. Eur J Pediatr. 2023 Oct 23. 

Relationship between hemodynamic type and syncopal symptoms in pediatric vasovagal syncope.

Wang S, et al. Eur J Pediatr. 2023 Oct 19. 

The effect of age on outpatient pediatric procedural sedation with intranasal dexmedetomidine and oral midazolam.

Zhou X, et al. Eur J Pediatr. 2023 Oct 19. 

A Systematic Approach to Evaluate Sudden Unexplained Death in Children.

Pries AM, et al. J Pediatr. 2023 Oct 16.

A 20-year Study of Intracranial Pyogenic Complications of Sinusitis in Children.

Smiljkovic M, et al. Pediatr Infect Dis J. 2023 Oct 12. 

Tracking of Cardiorespiratory Fitness from Childhood to Mid-Adulthood.

Guo J, et al. J Pediatr. 2023 Oct 15. 

Assessment of the Clinical Course of Human Rhinovirus/Enterovirus Infections in Pediatric Intensive Care.

Kocoglu Barlas U, et al. Pediatr Infect Dis J. 2023 Oct 9. 

Differentiate Clinical Characteristics Between Viral Pneumonia and Mycoplasma pneumoniae and Nomograms for Predicting Mycoplasma pneumoniae: A Retrospective Study in Primary Hospitals.

Guo H, et al. Pediatr Infect Dis J. 2023 Oct 9. 

Doxycycline for the Treatment of Lyme Disease in Young Children.

Brown K, et al. Pediatr Infect Dis J. 2023 Oct 5. 

Acute pharyngitis in children and adults: descriptive comparison of current recommendations from national and international guidelines and future perspectives.

Pellegrino R, et al. Eur J Pediatr. 2023 Oct 11. 

Comparison of amoxicillin administered twice and three times daily in children with acute otitis media.

Storch-De-Gracia P, et al. Eur J Pediatr. 2023 Oct 10. 

Reference Values for Cardiorespiratory Fitness in Patients Aged 6 to 18 Years.

Griffith GJ, et al. J Pediatr. 2023 Oct 4. 

Renal angina index for early identification of risk of acute kidney injury in critically ill children.

Alves MTB, et al. Pediatr Nephrol. 2023 Oct 5. 

The effect of myocardial dysfunction on mortality in children with septic shock: a prospective observational study.

Soydan E, et al. Eur J Pediatr. 2023 Oct.

Persistence of Autism Spectrum Disorder From Early Childhood Through School Age.

Harstad E, et al. JAMA Pediatr. 2023 Oct 2. 

Review of outpatient procedural sedation clinics in a tertiary paediatric hospital in South Australia.

Jung-Tang N, et al. J Paediatr Child Health. 2023 Oct. 

Screen Time at Age 1 Year and Communication and Problem-Solving Developmental Delay at 2 and 4 Years.

Takahashi I, et al. JAMA Pediatr. 2023 Oct 1. 

Development and evaluation study of FLY-Kids: a new lifestyle screening tool for young children.

Krijger A, et al. Eur J Pediatr. 2023 Oct. 

Trends in Anesthesia/Sedation for Computed Tomography and Magnetic Resonance Imaging Encounters in Pediatric Emergency Departments, 2012-2022.

Hayatghaibi SE, et al. JAMA Pediatr. 2023 Oct 1.

Proton Pump Inhibitor Use and Risk of Serious Infections in Young Children.

Lassalle M, et al. JAMA Pediatr. 2023 Oct 1. 

Questionable Safety of Proton Pump Inhibitor Use in Children.

Berry JG, et al. JAMA Pediatr. 2023 Oct 1. 

Factors associated with physical inactivity among the pre-school children: A cohort of 1681 participants.

Huang J, et al. J Paediatr Child Health. 2023 Oct. 

Infants born during the COVID-19 pandemic have less interest in masked faces than unmasked faces.

Byrne S, et al. Arch Dis Child. 2023 Oct. 

Role of preoperative in-hospital delay on appendiceal perforation while awaiting appendicectomy (PERFECT): a Nordic, pragmatic, open-label, multicentre, non-inferiority, randomised controlled trial.Jalava K, et al. Lancet. 2023 Oct 28.

3.Guidelines and best evidence

Shorter versus longer duration of antibiotic treatment in children with bacterial meningitis: a systematic review and meta-analysis.

Sudo RYU, et al. Eur J Pediatr. 2023 Oct 23. 

Evidence-based clinical practice guideline for management of urinary tract infection and primary vesicoureteric reflux.

Hari P, et al. Pediatr Nephrol. 2023 Oct 28. 

Responding to Parental Requests for Nondisclosure to Patients of Diagnostic and Prognostic Information in the Setting of Serious Disease.

Taub S, et al. Pediatrics. 2023 Oct 1. 

Advances in pediatric acute kidney injury pharmacology and nutrition: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference.

Wong Vega M, et al. Pediatr Nephrol. 2023 Oct 25. 

Promoting optimal mental health outcomes for children and youth.

Arruda W, et al. Paediatr Child Health. 2023 Oct 25. 

Probiotics, Prebiotics, Lactoferrin, and Combination Products for Prevention of Mortality and Morbidity in Preterm Infants: A Systematic Review and Network Meta-Analysis.

Wang Y, et al. JAMA Pediatr. 2023 Oct 2.

Infants Eligible for Neonatal Hypoglycemia Screening: A Systematic Review.

O’Brien M, et al. JAMA Pediatr. 2023 Oct 2. 

Coeliac disease and its implications on the oral health of children: A systematic review.

Turska-Szybka A, et al. J Paediatr Child Health. 2023 Oct. 

Sudden cardiac arrest in infants and children: proposal for a diagnostic workup to identify the etiology. An 18-year multicenter evaluation in the Netherlands.Bakker AM, et al. Eur J Pediatr. 2023 Oct 27.

4.Case reports

9-Year-old With Altered Mental Status.

Hamidpour S, et al. Pediatr Infect Dis J. 2023 Nov 1. 

Recurrent indurated red plaques.

Al Rumhi T, et al. J Paediatr Child Health. 2023 Oct 19. 

Chronic Crusted Plaque After Skin Injury.

Mahoney MJ, et al. J Pediatr. 2023 Oct 12. 

A 16-year-old female with a bullous rash.

Mahoney MJ, et al. Paediatr Child Health. 2023 Apr 27. 

Intracranial Empyema in Children: A Single-center Retrospective Case Series.Gilchrist JJ, et al. Pediatr Infect Dis J. 2023 Nov 1.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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