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Bubble Wrap PLUS – February 2024


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric Journal Club reading list from Professor Jaan Toelen (University Hospitals Leuven) and Dr Anke Raaijmakers (Sydney Children’s Hospital). 

This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research.

In the review part of the list, we found an interesting systematic review in JAMA Pediatrics about the relationship between 100% juice consumption and weight gain. The authors concluded that one serving a day of 100% fruit juice was associated with increasing BMI. Their findings support guidance to limit the consumption of fruit juice and prevent excess calorie intake and weight gain. Although parents often think that 100% fruit juice is ‘healthy,’ we should remind them that the extra calories might outweigh the benefits.

Next in the ‘healthy eating habit literature’ is a study by Peprah and colleagues, published in the European Journal of Pediatrics, looking at the association between skipping breakfast and mental health. The study surveyed 2855 Canadian adolescents in 2018 and found that those who skipped breakfast were 2.55 times more likely to report higher psychosomatic symptoms (AOR = 2.55; 95% CI = 1.75-3.82). Intermittent fasting seems to be a trend among youth and adults to maintain a healthy weight, but as always, we must be cautious not to blindly follow trends and be aware of the impact on mental health.

But what if the eating habits of your adolescent patients are fine, but they are just not moving around enough? In the same journal, Kizilkan and colleagues examined the relationship between bone health and problematic video gaming (more than 2 hours a day). Although sedentary behaviours have been linked to decreased bone mass, there is limited research on how video gaming impacts bone health. The authors compared bone mineral densitometry of adolescents with and without problematic video gaming. They found that the gaming group had lower femoral neck z-scores and higher femoral neck BMD risk, yet the lumbar spine z-scores did not differ. Despite more symptoms of depression and lower sleep quality in the gaming group, they were not associated with low BMD risk.

On the other end of the paediatric age spectrum, a meta-analysis in the Journal of Pediatrics found inconsistencies between pictures on baby diaper packaging and safe infant sleep recommendations. They attempted to identify all images on the packaging of baby diapers sold across Europe. They looked at (i) non-supine sleeping position, (ii) soft objects or loose bedding with the child, and (iii) co-sleeping. Their main outcome measure was the proportion of pictures inconsistent with current safety recommendations. Half showed a picture of a sleeping baby. Most (80%) had at least one inconsistency with current infant sleep recommendations. They conclude that the prevention of sudden unexpected death in infancy requires action from manufacturers and legislators to minimize parents’ exposure to misleading images that may lead to dangerous practices.

Paediatric advocacy still has a long road ahead…

You will find the list is broken down into four sections:

1.Reviews and opinion articles

The ongoing impact of obesity on childhood hypertension.

Myette RL, Flynn JT. Pediatr Nephrol. 2024 Jan 8. 

Nonoperative Management of Appendicitis in Children: An Update.

Jobson M, Hall NJ, Stanton M. Pediatr Infect Dis J. 2024 Jan 1;43(1):e11-e13. 

Addressing common questions on food oral immunotherapy: a practical guide for paediatricians. 

Anagnostou A, et al. Arch Dis Child. 2024 Jan 12:archdischild-2023-326225. 

Role of diagnostic tests for sepsis in children: a review. 

Rodgers O, et al. Arch Dis Child. 2024 Jan 23:archdischild-2023-325984.

2.Original clinical studies

Cardiopulmonary function in paediatric post-COVID-19: a controlled clinical trial.

Schoeffl I, et al. Eur J Pediatr. 2024 Jan 9. 

Corrected Age at Bayley Assessment and Developmental Delay in Extreme Preterms.

Garfinkle J, et al. Pediatrics. 2024 Jan 8:e2023063654. 

The Prematurity Paradox: Reevaluating the Kindergarten Readiness of Former Preterm Infants.

Barile JG, Han K, Milanaik R. Pediatrics. 2024 Jan 8:e2023063801. 

Association between breakfast skipping and psychosomatic symptoms among Canadian adolescents.

Peprah P, et al. Eur J Pediatr. 2024 Jan 6. 

Problematic video gaming is negatively associated with bone mineral density in adolescents.

Pehlivanturk Kizilkan M, et al. Eur J Pediatr. 2024 Jan 2. 

Transition to Adulthood for Extremely Preterm Survivors.

Pigdon L, et al. Pediatrics. 2024 Jan 1;153(1):e2022060119. 

Invasive Pneumococcal Disease After 2 Decades of Pneumococcal Conjugate Vaccine Use.

Yildirim I, et al. Pediatrics. 2024 Jan 1;153(1):e2023063039. 

Zonulin as a Biomarker for the Development of Celiac Disease.

DaFonte TM, et al. Pediatrics. 2024 Jan 1;153(1):e2023063050. 

Trampoline Park Injury Trends.

Teague WJ, et al. Pediatrics. 2024 Jan 1;153(1):e2023061659. 

Rare De Novo and Inherited Genes in Familial and Nonfamilial Pediatric Attention-Deficit/Hyperactivity Disorder.

Arnett AB, et al. JAMA Pediatr. 2024 Jan 1;178(1):81-84. 

Inconsistency Between Pictures on Baby Diaper Packaging in Europe and Safe Infant Sleep Recommendations.

de Visme S, et al. J Pediatr. 2024 Jan;264:113763. 

Worldwide Newborn Screening and Early Immunizations: Aligning Advances in Preventive Pediatrics.

Grob F, Odame I, Van Vliet G. J Pediatr. 2024 Jan;264:113732. 

Music Therapy During Basic Daily Care in Critically Ill Children: A Randomized Crossover Clinical Trial.

Mounier S, et al. J Pediatr. 2024 Jan;264:113736. 

Contaminant Organism Growth in Febrile Infants at Low Risk for Invasive Bacterial Infection. 

Singh NV, et al. Pediatric Emergency Medicine Collaborative Research Committee Febrile Infants; Health Disparities Study Group. J Pediatr. 2024 Jan 11:113910. 

Are sucking patterns and early spontaneous movements related to later developmental functioning outcomes? A cohort study. 

Yardımcı-Lokmanoğlu BN, et al. Eur J Pediatr. 2024 Jan 13. 

Early parenteral nutrition is associated with improved growth in very low birth weight infants: a retrospective study. 

Shen RL, et al. Arch Dis Child Fetal Neonatal Ed. 2024 Jan 11:fetalneonatal-2023-325829. 

Sustained inflation and chest compression versus 3:1 chest compression to ventilation ratio during cardiopulmonary resuscitation of asphyxiated newborns (SURV1VE): A cluster randomised controlled trial. 

Schmölzer GM, et al. SURV1VE- Trial Investigators. Arch Dis Child Fetal Neonatal Ed. 2024 Jan 11:fetalneonatal-2023-326383. 

Analysis of risk factors for acute kidney injury in children with severe wasp stings. 

Lu J, et al. Pediatr Nephrol. 2024 Jan 10. doi: 10.1007/s00467-023-06265-6. 

Thickening human milk: the effect of time, temperature, and thickener for infants with dysphagia. 

Brooks L, et al. Eur J Pediatr. 2024 Jan 26. 

Assessing fluid responsiveness with ultrasound in the neonatal intensive care setting: the mini-fluid challenge. 

de Waal K, Petoello E. Eur J Pediatr. 2024 Jan 26. 

Respiratory Syncytial Virus and Influenza During the COVID-19 Pandemic: A Two-center Experience. 

Kurz H, et al. Pediatr Infect Dis J. 2024 Jan 22. 

Evaluation of a Large Language Model to Identify Confidential Content in Adolescent Encounter Notes. 

Rabbani N, et al. JAMA Pediatr. 2024 Jan 22:e236032. 

Antimicrobial prophylaxis for vesicoureteral reflux: which subgroups of children benefit the most? 

Zhao B, et al. Pediatr Nephrol. 2024 Jan 20. 

Does ECG monitoring affect resuscitation for neonates with pulseless electrical activity in the delivery room? A simulated, pilot, crossover randomised trial. 

Assaad MA, et al. Arch Dis Child Fetal Neonatal Ed. 2024 Jan 17:fetalneonatal-2023-326099. 

Learning From a National Quality Improvement Collaborative for Brief Resolved Unexplained Events. 

Hochreiter D, et al. Pediatrics. 2024 Jan 17:e2022060909. 

Doxapram for apnoea of prematurity and neurodevelopmental outcomes at age 5-6 years. 

Tréluyer L, et al. Arch Dis Child Fetal Neonatal Ed. 2024 Jan 16:fetalneonatal-2023-326170. 

Procedural sedation programme minimising adverse events: a 3-year experience from a tertiary paediatric emergency department. 

Erumbala G, et al. Arch Dis Child. 2024 Jan 22;109(2):88-92. 

Back to the Future: Intravenous Fosfomycin Is Safe and Effective for the Treatment of Complicated Infections in Children. 

Roversi M, et al. Pediatr Infect Dis J. 2024 Jan 31. 

Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children. 

Ma HY, et al. Pediatr Infect Dis J. 2024 Jan 31. 

Substance Use, Suicidal Thoughts, and Psychiatric Comorbidities Among High School Students. 

Tervo-Clemmens B, et al. JAMA Pediatr. 2024 Jan 29. 

Complementary and alternative medicine (CAM) is frequently used by parents for the treatment of functional constipation in children. 

Nelson J, et al. J Pediatr Gastroenterol Nutr. 2024 Jan 29.

4.Case reports

12-Year-old Boy With Fever, Headache and Vomiting.

Atay Ünal N, et al. Pediatr Infect Dis J. 2024 Jan 1;43(1):88-90. 

Atypical Cat Scratch Disease With Splenic Lesion Mimicking Kawasaki Disease in a Healthy 5-Year-old Girl.

Ma M, Aoki Y, Kitazawa K. Pediatr Infect Dis J. 2024 Jan 1;43(1):e16-e19. 

Unusual Pediatric Red Eye. 

Ercanbrack CW, et al. J Pediatr. 2024 Jan 23:113924. 

Clivus Osteomyelitis as a Complication of Retropharyngeal Abscess in an Immunocompetent Adolescent. 

Ekemen C, et al. Pediatr Infect Dis J. 2024 Jan 18. 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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