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Bubble Wrap PLUS – October


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list from Anke Raaijmakers, who is working with Professor Jaan Toelen and his team at the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or keep your finger on the pulse of paediatric research.

This month’s list features answers to intriguing questions such as: ‘Is there a reliable calculator to predict early onset sepsis in neonates?’, ‘Do we see fewer congenital CMV infections due to the pandemic?’, ‘Is it useful to do pre-emptive interventions when suspecting autism?’, ‘How long do children need to sit to develop back pain?’ and ‘Should we reduce screen time after a concussion?

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Can I breastfeed my baby with Down syndrome? A scoping review.

Zhen L, et al. J Paediatr Child Health. 2021 Sep 29. 

Clinical ethics: consent for vaccination in children.

Wilkinson D, et al. Arch Dis Child. 2021 Sep 27:archdischild-2021-322981. 

Assessment, diagnosis, and management of developmental coordination disorder.

Ip A, et al. Paediatr Child Health. 2021 Sep 17;26(6):375-378. 

Half Century Since SIDS: A Reappraisal of Terminology.

Shapiro-Mendoza CK, et al. Pediatrics. 2021 Oct;148(4):e2021053746. 

Facemasks during COVID-19 and the importance of smiles in developmental assessment.

Snow L. Arch Dis Child. 2021 Sep 3:archdischild-2021-322659.

2.Original clinical studies

Late Pre-term Infants With Severe Bronchiolitis and Risk of Asthma by Age 5 Years.

Mansbach JM, et al. J Pediatr. 2021 Sep 29:S0022-3476(21)00913-6. 

Antenatal corticosteroids and neurodevelopmental outcomes in late preterm births.

Aviram A, et al. Arch Dis Child Fetal Neonatal Ed. 2021 Sep 29 

Decreasing Continuous Positive Airway Pressure Failure in Preterm Infants.

Kakkilaya VB, et al. Pediatrics. 2021 Oct;148(4):e2020014191. 

Neonatal Early Onset Sepsis: Impact of Kaiser Calculator in an Italian Tertiary Perinatal Center.

Pontello E, et al. Pediatr Infect Dis J. 2021 Sep 9. 

Machine Learning Used to Compare the Diagnostic Accuracy of Risk Factors, Clinical Signs and Biomarkers and to Develop a New Prediction Model for Neonatal Early-onset Sepsis.

Stocker M, et al. Pediatr Infect Dis J. 2021 Sep 9. 

Maternal antibiotics exposure during pregnancy and the risk of acute lymphoblastic leukemia in childhood: a systematic review and meta-analysis.

Zhu X, et al. Eur J Pediatr. 2021 Sep 17. 

Maternal Periconceptional Folic Acid Supplementation and Risk for Fetal Congenital Heart Defects.

Wang D, et al. J Pediatr. 2021 Sep 8:S0022-3476(21)00876-3. 

Child growth and neurodevelopment after maternal antenatal antibiotic treatment.

Videman K, et al. Arch Dis Child. 2021 Sep 3:archdischild-2021-322043. 

Perinatal outcomes among births to women with infection during pregnancy.

Baguiya A, et al. Arch Dis Child. 2021 Oct;106(10):946-953. 

Lower prevalence of congenital cytomegalovirus infection in Portugal: possible impact of COVID-19 lockdown?

Fernandez C, et al. Eur J Pediatr. 2021 Sep 30:1-4. 

The Role of Antenatal and Postnatal Maternal Bonding in Infant Development.

Le Bas G, et al. J Am Acad Child Adolesc Psychiatry. 2021 Sep 17:S0890-8567(21)01810-4. 

Postoperative Rather Than Preoperative Neutropenia Is Associated With Early Catheter-related Bloodstream Infections in Newly Diagnosed Pediatric Cancer Patients.

Cher WQ, et al. Pediatr Infect Dis J. 2021 Sep 28. 

Psychosocial functioning in adolescents growing up with chronic disease: The Dutch HBSC study.

Berkelbach van der Sprenkel EE, et al. Eur J Pediatr. 2021 Sep 30. 

Elevated liver enzymes of newly diagnosed pediatric celiac patients-a prospective-observational study.

Regev A, et al. Eur J Pediatr. 2021 Sep 29. 

Prevalence of neurological problems in a community-based sample of paediatric coeliac disease: a cross-sectional study.

O’Neill T, et al. Arch Dis Child. 2021 Sep 28:archdischild-2021-321770. 

Predictors of Changes in Height, Weight, and Body Mass Index after Initiation of Central Nervous System Stimulants in Children with Attention-Deficit/Hyperactivity Disorder.

Waxmonsky JG, et al. J Pediatr. 2021 Sep 24:S0022-3476(21)00906-9. 

Dynamics of RT-PCR and Serologic Test Results in Children with SARS-CoV-2 Infection.

Tagarro A, et al. J Pediatr. 2021 Sep 24:S0022-3476(21)00905-7. 

Association Between Leisure Screen Time and Emotional and Behavioural Problems in Spanish Children.

Cartanyà-Hueso À, et al. J Pediatr. 2021 Sep 24:S0022-3476(21)00907-0. 

Impact of the coronavirus pandemic on anorexia nervosa and atypical anorexia nervosa presentations to an Australian tertiary paediatric hospital.

Springall G, et al. J Paediatr Child Health. 2021 Sep 27. 

Risk factors for acute kidney injury after pediatric cardiac surgery: a meta-analysis.

Van den Eynde J, et al. Pediatr Nephrol. 2021 Sep 30. 

Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial.

NICUSeq Study Group. JAMA Pediatr. 2021 Sep 27. 

Nature and Children’s Health: A Systematic Review.

Fyfe-Johnson AL, et al. Pediatrics. 2021 Oct;148(4):e2020049155. 

Increasing rate of a positive family history of inflammatory bowel disease (IBD) in pediatric IBD patients.

Ruban M, et al. Eur J Pediatr. 2021 Sep 26. 

Obstructive sleep apnea in children with Down syndrome: is it possible to predict severe apnea?

Hizal M, et al. Eur J Pediatr. 2021 Sep 25:1-9. 

Burnout and Perceptions of Stigma and Help-Seeking Behavior Among Pediatric Fellows.

Weiss AK, et al. Pediatrics. 2021 Oct;148(4):e2021050393. 

Medication chart review at end of life of paediatric palliative patients.

Soo JEJ, et al. J Paediatr Child Health. 2021 Sep 23. 

A Text-Based Intervention to Promote Literacy: An RCT.

Chamberlain LJ, et al. Pediatrics. 2021 Oct;148(4):e2020049648. 

Effect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism: A Randomized Clinical Trial of Outcomes to Diagnosis.

Whitehouse AJO, et al. JAMA Pediatr. 2021 Sep 20:e213298. 

The Presentation of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Not Influenced by the Presence or Absence of Joint Hypermobility.

Vogel SK, et al. J Pediatr. 2021 Sep 16:S0022-3476(21)00887-8. 

Healthcare Experiences Of Gender Diverse Youth Across Clinical Settings.

Sequeira GM, et al. J Pediatr. 2021 Sep 15:S0022-3476(21)00888-X. 

Assessing the optimal time interval between growth measurements using a combined data set of weights and heights from 5948 infants.

Wright CM, et al. Arch Dis Child. 2021 Sep 14:archdischild-2021-322479. 

How Much Does Serum 25(OH)D Improve by Vitamin D Supplement and Fortified Food in Children? A Systematic Review and Meta-Analysis.

Nikooyeh B, et al. J Pediatr Gastroenterol Nutr. 2021 Sep 13. 

Depression in Adolescent Females With Heavy Menstrual Bleeding.

Weyand AC, et al. J Pediatr. 2021 Sep 10:S0022-3476(21)00880-5. 

Exceeding 2-h sedentary time per day is not associated with moderate to severe spinal pain in 11- to 13-year-olds: a cross-sectional analysis.

Montgomery LRC, et al. Eur J Pediatr. 2021 Sep 12. 

Trajectories of Suicidal Thoughts and Behaviors From Preschool Through Late Adolescence.

Whalen DJ, et al. J Am Acad Child Adolesc Psychiatry. 2021 Sep 

Making a diagnosis of periodic fever syndrome: Experience from a single tertiary centre.

McNaughton P, et al. J Paediatr Child Health. 2021 Sep 9. 

Development of an integrated competency framework for postgraduate paediatric training: a Delphi study.

Robbrecht M, et al. Eur J Pediatr. 2021 Sep 8:1-10. 

High-Intensity Interval Training and Cardiometabolic Risk Factors in Children: A Meta-analysis.

Solera-Martínez M, et al. Pediatrics. 2021 Oct;148(4):e2021050810. 

Effect of Screen Time on Recovery From Concussion: A Randomized Clinical Trial.

Macnow T, et al. JAMA Pediatr. 2021 Sep 7:e212782. 

A Definitive Answer to the Effect of Screen Time on Concussion Recovery.

Chrisman SPD. JAMA Pediatr. 2021 Sep 7. 

Timing of Introduction to Solid Food, Growth, and Nutrition Risk in Later Childhood.

D’Hollander CJ, et al. J Pediatr. 2021 Sep 2:S0022-3476(21)00861-1. 

Off-label drug use in paediatric haemato-oncology patients: financial implications and proposed solutions for Belgian patients.

Bauters T, et al. Eur J Pediatr. 2021 Sep;180(9):3067-3071. 

Household Transmission of SARS-CoV-2 from Children and Adolescents.

Chu VT, et al. N Engl J Med. 2021 Sep 2;385(10):954-956.

4.Case reports

Severe Cyanosis in a Toddler.

Dalby ST, et al. J Pediatr. 2021 Sep 28:S0022-3476(21)00912-4. 

From testis to brucellosis: A report of two paediatric cases presenting with acute scrotum.

Bako D, et al. J Paediatr Child Health. 2021 Sep 30. 

The limping child’s curvy diagnosis.

Wong NX, et al. J Paediatr Child Health. 2021 Sep 30. 

Recipe for Disaster: Homemade Formula Leading to Severe Complications in 2 Infants.

Vieira MA, et al. Pediatrics. 2021 Sep;148(3):e2021050947. 

Case 27-2021: A 16-Year-Old Boy Seeking Human Immunodeficiency Virus Prophylaxis.

Neilan AM, et al. N Engl J Med. 2021 Sep 9;385(11):1034-1041. 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.

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