Basic pharmacology

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Cite this article as: Anders, M. Basic pharmacology, Don't Forget the Bubbles, 2013. Available at: http://doi.org/10.31440/DFTB.3866Routes of administration and systemic absorption of drugs: Rate of systemic absorption determines onset, intensity and duration of action. Drug solubility and blood flow to the site of absorption are the most important factors: Oral/enteral: most convenient & economic route…

Nitric oxide

Cite this article as: Anders, M. Nitric oxide, Don't Forget the Bubbles, 2013. Available at: http://doi.org/10.31440/DFTB.3693Definition: nitric oxide (NO) is produced in the endothelium by eNOS (endothelial nitric oxide synthase).

Heart transplantation

Heart transplantation

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Cite this article as: Anders, M. Heart transplantation, Don't Forget the Bubbles, 2013. Available at: http://doi.org/10.31440/DFTB.3669Indication: life expectancy <2 years and/or unacceptable quality of life, end stage CHD, DCM, HCM (see cardiomyopathy) Risk profile: PVR (low risk: PVR ≤4 WU or TPG ≤10 mmHg, medium risk: PVR 5-9 WU or TPG 10-20 mmHg) High risk/contraindicated: PVR >9…

Myocarditis

Cite this article as: Anders, M. Myocarditis, Don't Forget the Bubbles, 2013. Available at: http://doi.org/10.31440/DFTB.3794See cardiomyopathy , but cardiac MRI or endomyocardial biopsy to confirm diagnosis Symptoms:  Very nonspecific in children: malaise, fever, poor appetite, tachypnea, tachycardia, chest pain, abdominal pain, myalgia, fatigue, cough, oedema, hepatomegaly, murmur. Investigations: See also cardiomyopathy Nonspecific T changes on ECG…

Heart failure and ventricular assist device (VAD)

Cite this article as: Anders, M. Heart failure and ventricular assist device (VAD), Don't Forget the Bubbles, 2013. Available at: http://doi.org/10.31440/DFTB.3790Modified Ross heart failure classification: Class Symptoms I Asymptomatic II Mild tachypneoa or diaphoresis with feeding. Dyspnea on exertion in older children III Marked tachypnea or diaphoresis with feeding; marked dyspnea on exertion; prolonged feeding time with…

ECMO antibiotics

Cite this article as: Anders, M. ECMO antibiotics, Don't Forget the Bubbles, 2013. Available at: http://doi.org/10.31440/DFTB.3783 Indication Prophylaxis Timing Duration ECMO (cannulation, chest revision, reoperation on ECMO, decannulation) – if not on anitbiotics with both gramnegative and grampositive cover already Cephazolin 50mg/kg up to 1g IV or (if cephazolin unavailable)Cephalothin 50mg/kg up to 2g IV Optimal timing for…