You receive a phone-call from the mother of a 7 year old diabetic – he’s been unwell all day with temps and coryzal symptoms and he’s off his food. The BSLs have been creeping up all day and are now 16 mmol/l. She’s not sure what else to do so they are on their way into hospital.
You’re the paeds reg on and it’s down to you to manage this before he gets into DKA. Are you up to the task?
The BSLs can be high or low.
With vomiting and diarrhoea, the BSLs may well be low due to reduced intake but also poor absorption from oral intake.
Although it might seem counter-intuitive, BSLs often go high even though the child is unwell and not eating as much as normal (particularly with pyrexial illnesses). The body’s stress response is to produce more glucose and this is often resistant to insulin.
When your patient has high BSLs (>15 mmol/l) and is unwell, the main focus is to keep an eye on the ketone level because the illness could potentially lead to DKA if not managed correctly – blood ketones are preferable to urine ketones as they show up earlier.
Blood Ketone Levels
<0.6 mmol/l Negative or trace
0.6-1.5 mmol/l Small to moderate
>1.5 mmol/l Moderate to large
Urine Ketone Levels
Small (+, 1 mmol/l or 10 mg/dl)
Moderate (++, 5 mmol/l or 50 mg/dl)
Large (+++, 15 mmol/l or 150 mg/dl)
If ketones are present and BSL>15 mmol/l, give extra insulin as below and then check again in 2 hours. Don’t go overboard with checking every five minutes!
There are three key aims of management: prevent dehydration; prevent DKA; and prevent hypoglycaemia.
- Encourage the patient to drink fluids (carbs if BSL<8 mmol/L and sugar-free if BSL>8 mmol/l) – go for small volumes often.
- Keep the normal insulin doses going if sugars are high!
Give extra doses according to the table. Add up the total number of units per day and then work out the percentage accordingly (i.e. if the patient has 20 units of insulin per day then 10% will be 2 units). If you are needing to give repeated doses then make sure the consultant is aware.
|Blood ketones <0.6 mmol/l; Urine: -ve or trace||Blood ketones 0.6-1.5 mmol/l; Urine: + to ++||Blood ketones >1.5 mmol/l; Urine: ++ to +++|
|BSL >15 mmol/l||Give 5% extra insulin. Repeat BSL and ketones in 2 hours.||Give 5-10% extra insulin. Repeat BSL and ketones in 2 hours.||Give 10-20% extra insulin. Repeat BSL and ketones hourly.|
|BSL 8-15 mmol/l||Repeat BSL in 2 hours. Consider 5% extra insulin if BSL remains elevated.||Repeat BSL and ketones in 2 hours. Give 5-10% extra insulin if BSL remains elevated.||Give 10% extra insulin. Repeat BSL and ketones in 2 hours.|
|BSL 4-8 mmol/l||Repeat BSL in 2 hours.||Give extra glucose/carbohydrate. Continue with regular insulin. Repeat BSL and ketones in 2 hours.||Give extra glucose/carbohydrate. Continue with regular insulin and consider 5% extra insulin if ketones do not clear. Repeat BSL hourly and ketones in 2 hours.|
|BSL<4 mmol/l||Give sweet fluids/food/carbohydrate. Repeat BSL in 30 mins. Continue with regular insulin but consider lowering doses. Consider glucagon. Consider hospital admission if BSL remains low.||Give sweet fluids/food/carbohydrate. Repeat BSL in 30 mins. Continue with regular insulin but consider lowering doses .Consider glucagon. Consider hospital admission if BSL remains low and ketones not clearing.||Give sweet fluids/food/carbohydrate. Repeat BSL in 30 mins. Continue with regular insulin but consider lowering doses. Consider glucagon. Consider hospital admission if BSL remains low.|
Use gastrolyte or hydralyte and additional carbs if needed. Follow the guide in the table.
If you really cannot push oral intake and the BSL is <4 mmol/l then consider glucagon
1 unit of glucagon per year of age (i.e. 7 units for a 7 year old) – administer just like an insulin injection. Then recheck BSL in 30 mins.
Ambler G, Cameron F. Caring for diabetes in children and adolescents. Blue Star Print Group: 3rd edition. 2010:p 98.