Henry Goldstein. Measles – A brief historical & clinical review, Don't Forget the Bubbles, 2015. Available at:
Bella, 11m, is brought to your emergency department by her parents. She’s had 3 days of cough with fears over 40oC, conjunctivitis and just today has developed a bright red rash along her hairline.
Although you’ve never seen a case before, you suspect measles.
- Measles is one of the classic febrile exanthematous illnesses.
- Although rare in the developed world, thanks to a good vaccination program & a historically well understood disease process, is still a major cause of childhood mortality worldwide.
- Measles outbreaks occur sporadically in areas with close contact and lower rates of vaccination.
- Measles may be the cause of fever & rash in a recently returned traveller from an endemic area.
- It is very contagious and there may be a need for large-scale post-exposure prophylaxis after a confirmed case.
- Children under five and immunocompromised patients are the most vulnerable to measles and complications thereof.
“It would be unfortunate if the classic sign of Koplik spots passed into history without a good facsimile of their appearance and a historical record of their description. As the use of measles vaccine grows more frequent and world-wide, future generations of physicians may not often see this important prodromal sign of measles. Already, many young North American physicians answer in the negative when asked ig they have ever actually seen these spots.” – Brem 1972
Measles is caused by a paramyxoviridae. It was considered the ‘first’ in the classical list of childhood febrile exanthems (along with Scarlet fever, rubella, ‘fifth disease’ et al), and was first described by the Persian physician ar-Razi (Razes) in 910 AD, in his “Treatise on the Small Pox and Measles”.
Measles was traditionally a disease of the city, with smaller outbreaks in rural or regional communities often more severe. There was a long held tradition of describing measles as ‘mild’ or ‘mortal’- some outbreaks, notably the 1875 Fiji Measles outbreak have had death rates in excess of 30%.
Since the introduction of a measles vaccine in 1963, the rates in the developed world have plummeted, approaching zero. Unfortunately, in the developing world, measles still kills about 400 people a day, mostly children.
Measles occurs in several phases:
Also around this time the pathognomic feature of measles, Koplik spots, can be seen. Koplik himself described them as “one of the most, if not the most, reliable sign of the invasion of measles”. In addition to preceding the exanthem, Koplik spots are said to appear prior to maximum infectivity. Interestingly, Koplik’s original paper quotes Osler’s description of the spots, but implies it is insufficient and, along with Henoch’s description is overly focussed on the pharynx.
“On the buccal mucous membrane and the inside of the lips, we invariably see a distinct eruption. It consists of small, irregular spots, of a bright red color. In the centre of each spot, there is noted, in strong daylight, a minute bluish white speck.” … “[I]t will be seen that the buccal eruption is of greatest diagnostic value at the outset of the disease, before the appearance of the skin eruption and at the outset and height of the skin eruption.” – Koplik, 1896
The period of contagiousness is taken from the appearance of the rash. It is thought to be from (day minus five) to (day plus four) of the onset of rash.
“But,” Bella’s parents say, “she’s immunised as per the Australian schedule!”
As per the Australian Immunisation schedule, the first dose of measles vaccine is given at 12 months. Seroconversion rates are described as 95% after the first vaccine, increasing to approximately 99% after a second vaccine. Irrespective of her immunisation status, Bella is not yet currently immune to measles, relying instead on herd immunity. This is also important for children whose immune status precludes immunisation with MMR, as it is a live attenuated vaccine. These patients include children on high-dose steroids, those with HIV (and a CD4+ count <15%), those receiving chemo- or radiation-therapy.
The Australian Immunisation Handbook specifically mentions that, if given <12 months of age, there is still a need for two doses >12 months, as persistent maternal antibodies to measles (up to 11 months) may interfere with active immunisation.
Complications of measles are more common in children, especially <5 years. About 1 in 5 children with measles will have at least one complication.
Acute otitis media occurs in 10%.
Lower respiratory tract infection occurs in 6% of measles cases; pneumonia is the most common cause of death.
1 in 1000 children will have a measles encephalitis, with a high mortality rate (greater than 10%). Survivors have neurologic sequelae.
Measles-associated immune suppression, particularly in the developing world, confers an increased risk of mortality for three years post-infection.
Subacute sclerosing pan encephalitis occurs in about 1/10,000 cases of measles, manifesting as a progressive, eventually fatal, deterioration including ataxia and seizures, typically seven years after infection.
What else could it be?
Having just described a petechial rash in a febrile child, we need to consider bacterial sepsis. Also recall the childhood febrile exanthems:
Exanthem 2 – Group A Streptococcus
Exanthem 3 – Rubella
Exanthem 4 – likely enterovirus
Exanthem 5 – B19 parvovirus
Exanthem 6 – Roseola infantum (HHV6)
Also, mycoplasma pneumonia (the great mimic!), EBV, adenovirus or other viruses should be considered, and it is reasonable to entertain the possibility of Kawasaki disease, Henoch-Schonlein purpura or other vasculitides too.
It’s particularly worth noting that a significant number of measles cases are contracted from measles endemic areas. That is, for cases in the developed world, it is (as always) essential to elicit a travel history. Likewise, consider measles as a differential diagnosis for the suspected Ebola patient in your isolation room (!).
If you’ve done a FBC and LFTs, you might see a leukopenia, a lymphopenia, and mildly raised transaminases.
We’ve mentioned several times above the period for which measles is contagious. Most notably, measles can survive for up to 2 hours in air, but is rapidly inactivated by heat, light, and extremes of pH. It is reasonable to assume that each case will have associated a number of contacts. Measles is likely to be a notifiable disease in your jurisdiction; and the Public Health Unit may refer contacts for post-exposure prophylaxis, thus:
Immunocompromised patients or those patients <9 months should receive a dose of ‘Normal Human Immunoglobulin’ (NHIG). Patients over 9 months who have yet to receive their first does of MMR vaccine should receive a vaccine, as should those over 12 months if they’re yet to receive a second MMR vaccine, provided their first dose was greater than four weeks previously. Pregnant patients should be offered NHIG.
Brem, J. Koplik Spots for the Record: An Illustrated Historical Note CLIN PEDIATR March 1972 11: 161-163,
Dobson, M. Disease. Oxford: BCS Publishing (2007) pp140-6.
Baxby, Derrick (July 1997). “Classic Paper: The diagnosis of the invasion of measles from a study of the exanthema as it appears on the buccal mucous membrane”. Reviews in Medical Virology 7 (2): 71–74.
Koplik, H.: The diagnosis of the invasion of measles from a study of the exanthema as it appears on the buccal mucous membrane. Arch. Pediat. 13: 918, 1896.
Kliegman R. (Ed.) Measles. Nelson essentials of pediatrics. Philadelphia, PA: Saunders/Elsevier. (2013)
Tasker, RC (Ed.) Exanthema 1; measles. Oxford Handbook of Paediatrics. Oxford: Oxford University Press. (2008) pp684
The Australian Immunisation Handbook 10th Edition (2013) via: www.immunise.health.gov.au
Measles – World Health Ogranisation. https://www.who.int/topics/measles/en/