Cite this article as: Anders, M. Weaning opioids and steroids, Don't Forget the Bubbles, 2013. Available at: http://doi.org/10.31440/DFTB.3890
Withdrawal from drugs (principally opioids) prolongs hospital admissions and causes morbidity!
Gradual weaning of drug dosing aims to prevent the onset of withdrawal abstinence syndromes:
regime one: 10% reduction in original dose per day weaning over 10 days or
regime two: 20% reduction in original dose per day weaning over 5 days
regime three: 20% reduction in original dose every 2nd day weaning over 10 days
All are equally effective and the shorter 5-day wean is not associated with any increased withdrawal symptoms requiring reinstitution of drug therapy
The choice of regime is typically arbitrary based on length of therapy and clinician choice.
Dose conversion of IV and enteral:
Dose escalation and/or opioid rotation are both effective ways to combat tolerance (although there is an inevitable amount of cross tolerance) but not physical dependence.
Converting between opioids and route of administration involves documenting the total 24-hour dose being administered and then using the conversion table and calculating a total daily dose of the new drug via the new route.
Drug
IV equivalent
IV : morphine ratio
enteral equivalent
IV : enteral ratio
Morphine
10mg
1 : 1
30 mg
1 : 3
Codeine
100mg
10 : 1
200mg
1 : 2
Oxycodone
10mg
1 : 1
20mg
1 : 2
Fentanyl
100mcg
0.01 : 1
n/a
n/a
Methadone
10mg
1 : 1
20mg
1 : 2
Dose conversion for IV midazolam into oral diazepam:
[Midazolam IV [rate in mcg/kg/min] x weight x 24 ] x 0.5 = Diazepam oral
References:
[1] Brunton, L et al (2010), Goodman and Gillman’s the Pharmacological Basis of Therapeutics 12th Edition, McGraw Hill Medical, New York [2] Macintyre, PE et al (2010), Acute Pain Management: Scientific Evidence 3rd Edition, Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine, Melbourne [3] Miller, RD et al (2009), Miller’s Anesthesia 9th Edition, Churchill Livingstone Elsevier, Philadelphia [4] Peck, TE & Hill, S (2008), Pharmacology for Anaesthesia and Intensive Care 3rd Edition, Cambridge University Press, Cambridge [5] Sasada, M & Smith, S (2003), Drugs in Anaesthesia and Intesive Care 3rd Edition, Oxford University Press, Oxford [6] Stoelting, RK & Hillier, SE (2005), Pharmacology and Physiology in Anesthetic Practise 4th Edition, Lippincott, Williams and Wilkins, Philadelphia [7] Pediatrics 2010 May;125(5):e1208-25: Anand et al: Tolerance and withdrawal from prolonged opioid use in critically ill children.
All Marc’s PICU cardiology FOAM can be found on PICU Doctor and can be downloaded as a handy app for free on iPhone or Android. A list of contributors can be seen here.
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Weaning opioids and steroids
Tags: morphine, oromorph, weaning
Anders, M. Weaning opioids and steroids, Don't Forget the Bubbles, 2013. Available at:
http://doi.org/10.31440/DFTB.3890
Withdrawal from drugs (principally opioids) prolongs hospital admissions and causes morbidity!
Gradual weaning of drug dosing aims to prevent the onset of withdrawal abstinence syndromes:
All are equally effective and the shorter 5-day wean is not associated with any increased withdrawal symptoms requiring reinstitution of drug therapy
The choice of regime is typically arbitrary based on length of therapy and clinician choice.
Dose conversion of IV and enteral:
Dose escalation and/or opioid rotation are both effective ways to combat tolerance (although there is an inevitable amount of cross tolerance) but not physical dependence.
Converting between opioids and route of administration involves documenting the total 24-hour dose being administered and then using the conversion table and calculating a total daily dose of the new drug via the new route.
Dose conversion for IV midazolam into oral diazepam:
References:
[1] Brunton, L et al (2010), Goodman and Gillman’s the Pharmacological Basis of Therapeutics 12th Edition, McGraw Hill Medical, New York [2] Macintyre, PE et al (2010), Acute Pain Management: Scientific Evidence 3rd Edition, Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine, Melbourne [3] Miller, RD et al (2009), Miller’s Anesthesia 9th Edition, Churchill Livingstone Elsevier, Philadelphia [4] Peck, TE & Hill, S (2008), Pharmacology for Anaesthesia and Intensive Care 3rd Edition, Cambridge University Press, Cambridge [5] Sasada, M & Smith, S (2003), Drugs in Anaesthesia and Intesive Care 3rd Edition, Oxford University Press, Oxford [6] Stoelting, RK & Hillier, SE (2005), Pharmacology and Physiology in Anesthetic Practise 4th Edition, Lippincott, Williams and Wilkins, Philadelphia [7] Pediatrics 2010 May;125(5):e1208-25: Anand et al: Tolerance and withdrawal from prolonged opioid use in critically ill children.All Marc’s PICU cardiology FOAM can be found on PICU Doctor and can be downloaded as a handy app for free on iPhone or Android. A list of contributors can be seen here.
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