ECMO (cannulation, chest revision, reoperation on ECMO, decannulation) – if not on anitbiotics with both gramnegative and grampositive cover already
Cephazolin 50mg/kg up to 1g IV or (if cephazolin unavailable)Cephalothin 50mg/kg up to 2g IV
Optimal timing for Beta-Lactams: administer 30 – 60min before incision
2nd dose 25mg/kg if operation > 3hrs, continue 25mg/kg 8hrly, remember to cease after 24hrs
Known MRSA infection or colonization, currently or in the past
Cephazolin 50mg/kg up to 1g IV plusVancomycin 25mg/kg up to 1.5g (child < 12yrs: 30mg/kg up to 1.5g)
Optimal timing for Beta-Lactams: administer 30 – 60min before incision; for Vancomycin: slow infusion, starting 60min before, and finishing immediately before incision, CVL not required
2nd dose 25mg/kg if operation > 3hrs, continue 25mg/kg 8hrly, remember to cease after 24hrs; no further doses of Vancomycin required
Penicillin / Cephalosporin allergy
Vancomycin 25mg/kg up to 1.5g (child < 12yrs: 30mg/kg up to 1.5g) IV plusGentamicin 2mg/kg IV
Optimal timing for Beta-Lactams: administer 30 – 60min before incision; for Vancomycin: slow infusion, starting 60min before, and finishing immediately before incision, CVL not required
No further doses required
ECMO (cannulation, chest revision, reoperation on ECMO, decannulation) – if on anitbiotics with both gramnegative and grampositive cover already
No further prophylaxis required
n/a
n/a
References:
[1] Therapeutic Guidelines: Antibiotic, 2006: Therapeutic Guidelines Ltd, Melbourne.
[2] Ann Thorac Surg 2006, 81:397-404: The Society of Thoracic Surgeons Practice Guideline Series: Antibiotic Prophylaxis in Cardiac Surgery, Part 1: Duration.
[3] The Society of Thoracic Surgeons Practice Guideline Series: Antibiotic Prophylaxis in Cardiac Surgery, Part 2: Antibiotic Choice. Ann Thorac Surg 2007;83:1596-76.
All Marc’s PICU cardiology FOAM can be found on PICU Doctor and can be downloaded as a handy app for free on iPhone or Android. A list of contributors can be seen here.
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ECMO antibiotics
Tags: antibiotics, ecmo, heart failure
Marc Anders. ECMO antibiotics, Don't Forget the Bubbles, 2013. Available at:
https://doi.org/10.31440/DFTB.3783
References:
[1] Therapeutic Guidelines: Antibiotic, 2006: Therapeutic Guidelines Ltd, Melbourne. [2] Ann Thorac Surg 2006, 81:397-404: The Society of Thoracic Surgeons Practice Guideline Series: Antibiotic Prophylaxis in Cardiac Surgery, Part 1: Duration. [3] The Society of Thoracic Surgeons Practice Guideline Series: Antibiotic Prophylaxis in Cardiac Surgery, Part 2: Antibiotic Choice. Ann Thorac Surg 2007;83:1596-76.All Marc’s PICU cardiology FOAM can be found on PICU Doctor and can be downloaded as a handy app for free on iPhone or Android. A list of contributors can be seen here.
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