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Bubble Wrap Plus – Oct 2018


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a mid-monthly paediatric journal club reading list  from Anke Raaijmakers working with Professor Jaan Toelen & his team of the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or simply help you to keep an finger on the pulse of paediatric research.

October’s list features answers to intriguing questions such as: ‘Does appendicitis run in families?’, ‘Is VR a good way to distract children from painful procedures?’, ‘Do antibiotics really work in appendicitis?’ and ‘Should I resuscitate preterms using 21% or 100% O2?’

You will find the list is broken down into four sections:

1. Reviews and opinion articles

Use of Oral Corticosteroids in the Wheezy Toddler.

Abrams EM, et al. J Pediatr. 2018 Oct;201:16-20.

Unveiling the RNA World.

Lieberman J. N Engl J Med. 2018 Sep 27;379(13):1278-1280.

Circumcision in the paediatric patient: A review of indications, technique and complications.

Prabhakaran S, et al. J Paediatr Child Health. 2018 Sep 23.

Cochrane review methods called into question.

Burki T. Lancet. 2018 Sep 15;392(10151):906.

When no guideline recommendation is the best recommendation.

Bretthauer M, et al. Lancet. 2018 Sep 15;392(10151):898-899.

Fetal hydrops: diagnosis and prognosis.

Waring GJ, et al. Arch Dis Child. 2018 Sep 14.

Medical Marijuana for Minors May Be Considered Child Abuse.

Hines L, et al. Pediatrics. 2018 Sep 13.

Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity.

Flume PA, et al. Lancet. 2018 Sep 8;392(10150):880-890.

Bronchiectasis in children: diagnosis and treatment.

Chang AB, et al. Lancet. 2018 Sep 8;392(10150):866-879.

Milk, mucus and myths.

Balfour-Lynn IM. Arch Dis Child. 2018 Sep 6.

State of the Science on Pediatric Mild Traumatic Brain Injury: Progress Toward Clinical Translation.

McCrea M, et al. JAMA Pediatr. 2018 Sep 4:e182846.

Seize the opportunity – Recognition and management of functional seizures in children.

Heyman I, et al. Eur J Paediatr Neurol. 2018 Sep;22(5):734-735.

Screening and Management of High Blood Pressure in Children and Adolescents.

Khoury M, et al. JAMA Pediatr. 2018 Sep 17.

The challenge of pain assessment in children with cognitive disabilities: Features and clinical applicability of different observational tools.

Cascella M, et al. J Paediatr Child Health. 2018 Sep 27.

2. Original clinical studies

Treatment of bronchiectasis exacerbations in children: which antibiotic?

Zar HJ, et al. Lancet. 2018 Sep 17.

Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial.

Goyal V, et al. Lancet. 2018 Sep 17.

Preterm Infant Outcomes after Randomization to Initial Resuscitation with FiO2 0.21 or 1.0.

Thamrin V, et al. J Pediatr. 2018 Oct;201:55-61.e1

Neuroimaging Profiles and Neurodevelopmental Outcome in Infants With Congenital Cytomegalovirus Infection.

Giannattasio A, et al. Pediatr Infect Dis J. 2018 Oct;37(10):1028-1033.

Adolescent Use of Different E-cigarette Products.

McMillen R, et al. Pediatrics. 2018 Sep 10.

Parental opinion of consent in neonatal research.

McCarthy KN, et al. Arch Dis Child Fetal Neonatal Ed. 2018 Sep 28.

Caesarean delivery, childhood asthma, and effect modification by sex: An observational study and meta-analysis.

Pennington AF, et al. Paediatr Perinat Epidemiol. 2018 Sep 28.

Fluid resuscitation in paediatric burns: how do we get it right? A systematic review of the evidence.

Stutchfield C, et al. Arch Dis Child. 2018 Sep 27.

Use of CT for Head Trauma: 2007-2015.

Burstein B, et al. Pediatrics. 2018 Sep 4.

Infant Colic Represents Gut Inflammation and Dysbiosis.

Rhoads JM, et al. J Pediatr. 2018 Aug 31.

Inconsolable Crying in Infants: Differential Diagnosis in the Pediatric Emergency Department.

Matijasic N, et al. Clin Pediatr (Phila). 2018 Sep 3:9922818798389.

Academic trajectories of very preterm born children at school age.

Twilhaar ES, et al. Arch Dis Child Fetal Neonatal Ed. 2018 Sep 27.

The problem of defecation disorders in children is underestimated and easily goes unrecognized: a cross-sectional study.

Timmerman MEW, et al. Eur J Pediatr. 2018 Sep 27.

Respiratory Health in Adolescents Born Moderately-Late Preterm in a Community-Based Cohort.

Vrijlandt EJLE, et al. J Pediatr. 2018 Sep 25.

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial.

Salminen P, et al. JAMA. 2018 Sep 25;320(12):1259-1265.

Antibiotic Treatment for Uncomplicated Appendicitis Really Works: Results From 5 Years of Observation in the APPAC Trial.

Livingston EH. JAMA. 2018 Sep 25;320(12):1245-1246.

Term Elective Cesarean Delivery and Offspring Infectious Morbidity – A Population Based Cohort Study.

Wainstock T, et al. Pediatr Infect Dis J. 2018 Sep 25.

Development of a quality improvement audit tool for the primary care of children with chronic wet cough using a modified Delphi consensus approach.

Prime SJ, et al. J Paediatr Child Health. 2018 Sep 24.

Is Breast Still Best From a Bottle?

Holmes AV. Pediatrics. 2018 Sep 24.

Infant Feeding and Weight Gain: Separating Breast Milk From Breastfeeding and Formula From Food.

Azad MB, et al. Pediatrics. 2018 Sep 24.

Phototherapy and Seizures: Should We Change Practice?

Taylor JA. Pediatrics. 2018 Sep 24.

Childhood Seizures After Phototherapy.

Newman TB, et al. Pediatrics. 2018 Sep 24.

Hyperbilirubinemia, Phototherapy, and Childhood Asthma.

Kuzniewicz MW, et al. Pediatrics. 2018 Sep 12.

Changes in bilirubin in infants with hypoxic-ischemic encephalopathy.

Dani C, et al. Eur J Pediatr. 2018 Sep 19.

Vitamin D Status at the Time of Hospitalization for Bronchiolitis and Its Association with Disease Severity.

Vo P, et al. J Pediatr. 2018 Sep 20.

Adiposity in Adolescents: The Interplay of Sleep Duration and Sleep Variability.

Jansen EC, et al. J Pediatr. 2018 Sep 20.

Recurrent Abdominal Pain in Children: Is Colonoscopy Indicated?

Singh HK, et al. J Pediatr Gastroenterol Nutr. 2018 Sep 18.

The Brussels Infant and Toddler Stool Scale: A Study On Inter-Observer Reliability.

Huysentruyt K, et al. J Pediatr Gastroenterol Nutr. 2018 Sep 20.

Pediatric ileocolic intussusception: new observations and unexpected implications.

Binkovitz LA, et al. Pediatr Radiol. 2018 Sep 19.

Assessment of clinical outcome of children with sepsis outside the intensive care unit.

Zallocco F, et al. Eur J Pediatr. 2018 Sep 17.

Individual screening strategy for pediatric celiac disease.

Poddighe D. Eur J Pediatr. 2018 Sep 17.

Gastric emptying in children with type 1 diabetes mellitus: A pilot study.

Porter JA, et al. J Paediatr Child Health. 2018 Sep 17.

Bladder Symptoms in Children with Functional Constipation: A Systematic Review.

van Summeren JJGT, et al. J Pediatr Gastroenterol Nutr. 2018 Sep 12.

Rate of Recurrence of Adverse Events Following Immunization: Results of 19 Years of Surveillance Ii Quebec, Canada.

Zafack JG, et al. Pediatr Infect Dis J. 2018 Sep 10.

Language Experience in the Second Year of Life and Language Outcomes in Late Childhood.

Gilkerson J, et al. Pediatrics. 2018 Sep 10.

Early Language Exposure and Middle School Language and IQ: Implications for Primary Prevention.

Mendelsohn AL, et al. Pediatrics. 2018 Sep 10.

Virtual reality distraction from painful procedures in the paediatric emergency department.

Knight K, et al. Arch Dis Child. 2018 Sep 7.

Elective replacement of intravenous cannula in neonates-a randomised trial.

Chin LY, et al. Eur J Pediatr. 2018 Sep 6.

Familial Risk of Appendicitis: A Nationwide Population Study.

Li HM, et al. J Pediatr. 2018 Sep 5.

Use of procalcitonin in the diagnosis of tuberculosis in infants and preschool children.

Velasco-Arnaiz E, et al. Eur J Pediatr. 2018 Sep;177(9):1377-1381.

Thresholds for Resuscitation of Extremely Preterm Infants in the UK, Sweden, and Netherlands.

Wilkinson D, et al. Pediatrics. 2018 Sep;142(Suppl 1):S574-S584.

4. Case reports

Primary Ebstein-Barr Virus Infection Presenting with Prominent Lip and Tongue Swelling.

Crighton BK, et al. J Paediatr Child Health. 2018 Sep;54(9):1052-1053

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.

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