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Bubble Wrap PLUS – November ’22


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list  from Anke Raaijmakers working with Professor Jaan Toelen & his team of the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or simply help you to keep an finger on the pulse of paediatric research.

This month’s list features answers to intriguing questions such as: ‘Can we use a clinical score to predict which preschool wheezers can stop with ICS?’, ‘Is there a guideline for head trauma in very young infants?’, ‘Can you give surfactant via a laryngeal mask?’, ‘Can we diagnose autism with the pull-to-sit manoeuvre?’, ‘Are antenatal steroids associated with childhood mental disorders?’ and ‘Does delaying the introduction of eggs increase the risk of egg allergy?’

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Head Lice.

Nolt D, et al. Pediatrics. 2022 Oct 1;150(4):e2022059282. 

Respiratory syncytial virus, recurrent wheeze and asthma: A narrative review of pathophysiology, prevention and future directions.

Binns E, et al. J Paediatr Child Health. 2022 Oct;58(10):1741-1746. 

Progress in diagnosis of primary ciliary dyskinesia.

Wei S, et al. J Paediatr Child Health. 2022 Oct;58(10):1736-1740. 

2.Original clinical studies

Probability of successful inhaled corticosteroids cessation in preschool wheezers: a predictive score.

Sirianansopa K, et al. Eur J Pediatr. 2022 Oct 27. 

Evaluation of antibiotic stewardship among near-term and term infants admitted to a neonatal unit.

Feng K, , et al. Eur J Pediatr. 2022 Oct 27

Probiotic supplementation in healthy pre-school-aged children: What, why, how and when?

Irwin N, et al. J Paediatr Child Health. 2022 Oct 11. 

Aerosol generation during paediatric procedural sedation with continuous-flow nitrous oxide suggests a low risk of airborne viral transmission to health-care workers.

Millar R, et al. J Paediatr Child Health. 2022 Oct 25. 

Evaluation of the PECARN rule for traumatic brain injury applied to infants younger than 3 months and creation of a modified, age-specific rule.

Alonso-Cadenas JA, et al. Eur J Pediatr. 2022 Oct 24. 

Acid Suppression and Antibiotics Administered During Infancy Are Associated with Celiac Disease.

Boechler M, et al. J Pediatr. 2022 Oct 17:S0022-3476(22)00900-3. 

Pediatric Eosinophilia: A Review and Multi-Year Investigation into Etiologies.

Ness TE, et al. J Pediatr. 2022 Oct 1:S0022-3476(22)00870-8. 

A secondary outcome analysis of a randomized trial using a mixed lipid emulsion containing fish oil in infants with extremely low birth weight: Cognitive and behavioral outcome at preschool age.

Thanhaeuser M, et al. J Pediatr. 2022 Oct 15:S0022-3476(22)00901-5. 

Febrile illness in high-risk children: a prospective, international observational study.

van der Velden FJS, et al. Eur J Pediatr. 2022 Oct 15. 

Delayed Surgical Closure of the Patent Ductus Arteriosus: does the Brain pay the Price?

Lemmers P, et al. J Pediatr. 2022 Oct 11:S0022-3476(22)00892-7. 

Association of gestation and fetal growth restriction on cardiovascular health in preterm-born children.

Course CW, et al. J Pediatr. 2022 Oct 11:S0022-3476(22)00889-7. 

Randomized trial of surfactant therapy via laryngeal mask airway versus brief tracheal intubation in preterm neonates.

Gallup JA, et al. J Pediatr. 2022 Oct 11:S0022-3476(22)00891-5. 

Epidemiological changes caused by the preventive measures for Covid-19 pandemic: an additional challenge for pediatricians.

Pettoello-Mantovani M, et al. J Pediatr. 2022 Oct 10:S0022-3476(22)00879-4. 

Characteristics of tummy time and dose-response relationships with development in infants.

Zhang Z, et al. Eur J Pediatr. 2022 Oct 12. 

Associations of Secretory Activation Breastmilk Biomarkers with Breastfeeding Outcome Measures.

Esquerra-Zwiers AL, et al. J Pediatr. 2022 Oct 5:S0022-3476(22)00877-0. 

Antenatal Corticosteroid Exposure Is Associated with Childhood Mental Disorders in Late Preterm and Term Infants.

Lin YH, et al. J Pediatr. 2022 Oct 3:S0022-3476(22)00872-1. 

The Pull-to-Sit Task: Examining Infant Postural Development in Autism Spectrum Disorder.

Bradshaw J, et al. J Pediatr. 2022 Oct 3:S0022-3476(22)00869-1. 

Cardiovascular health behavior and cardiorespiratory fitness in adolescents: a longitudinal study.

Agostinis-Sobrinho C, et al. Eur J Pediatr. 2022 Oct 6:1-9

A validated Screening instrument for Child Abuse and Neglect (SCAN) at the emergency department.

Hoedeman F, et al. Eur J Pediatr. 2022 Oct 5:1-9. 

Delayed egg introduction beyond infancy and increased egg allergy risk in childhood.

Martone GM, et al. J Paediatr Child Health. 2022 Oct 3. 

Standardizing the Evaluation and Management of Necrotizing Enterocolitis in a Level IV NICU.

Aurora M, et al. Pediatrics. 2022 Oct 1;150(4):e2022056616. 

Serious Bacterial Infections in Young Febrile Infants With Positive Urinalysis Results.

Mahajan P, et al. Pediatrics. 2022 Oct 1;150(4):e2021055633. 

Is Home Oxygen Therapy an Alternative to Hospitalization for Bronchiolitis?

Freeman JF, et al. Pediatrics. 2022 Oct 1;150(4):e2022058042. 

Risk factors of a severe course of pediatric multi-system inflammatory syndrome temporally associated with COVID-19.

Stasiak A, et al. Eur J Pediatr. 2022 Oct;181(10):3733-3738. 

Developmental monitoring: benefits of a preventive health care system.

Theunissen MHC, et al. Eur J Pediatr. 2022 Oct;181(10):3617-3623. 

Is acidemia at birth a risk factor for functional gastrointestinal disorders?

Indrio F, et al. Eur J Pediatr. 2022 Oct;181(10):3625-3633. 

Association between duration of early empiric antibiotics and necrotizing enterocolitis and late-onset sepsis in preterm infants: a multicenter cohort study.

Dierikx TH, et al. Eur J Pediatr. 2022 Oct;181(10):3715-3724. 

Efficacy of a loading dose of IV salbutamol in children with severe acute asthma admitted to a PICU: a randomized controlled trial.

Boeschoten SA, et al. Eur J Pediatr. 2022 Oct;181(10):3701-3709. 

Daycare Attendance is Linked to Increased Risk of Respiratory Morbidities in Children Born Preterm with Bronchopulmonary Dysplasia.

McGrath-Morrow SA, et al. J Pediatr. 2022 Oct;249:22-28.e1. 

Neonatal Docosahexaenoic Acid in Preterm Infants and Intelligence at 5 Years.

Gould JF, et al. N Engl J Med. 2022 Oct 27;387(17):1579-1588. 

Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021.

Global Burden of Disease Long COVID Collaborators JAMA. 2022 Oct 25;328(16):1604-1615. 

3.Guidelines and best evidence

The association between congenital cytomegalovirus infection and cerebral palsy: A systematic review and meta-analysis.

Ong LT, Fan SWD. J Paediatr Child Health. 2022 Oct 17. 

Evaluation for Bleeding Disorders in Suspected Child Abuse.

Anderst J, et al. Pediatrics. 2022 Oct 1;150(4):e2022059276. 

Evaluating for Suspected Child Abuse: Conditions That Predispose to Bleeding.

Carpenter , et al. Pediatrics. 2022 Oct 1;150(4):e2022059277. 

Home Care for Bronchiolitis: A Systematic Review.

Lawrence J, et al. Pediatrics. 2022 Oct 1;150(4):e2022056603. 

Factors Associated With Diabetic Ketoacidosis at Onset of Type 1 Diabetes Among Pediatric Patients: A Systematic Review.

Rugg-Gunn CEM, et al. JAMA Pediatr. 2022 Oct 10. 

Screening for Depression and Suicide Risk in Children and Adolescents: US Preventive Services Task Force Recommendation Statement.

US Preventive Services Task Force JAMA. 2022 Oct 18;328(15):1534-1542. 

4.Case reports

Eruptive hypomelanosis: an under-recognized viral exanthem.

Sil A, et al. J Pediatr. 2022 Oct 18:S0022-3476(22)00897-6. 

Recurrent syncope in a 16-year-old boy.

Gunn S, et al. J Paediatr Child Health. 2022 Oct 12. 

Milky ascitic fluid in a newborn.

Azmi JA, et al. J Paediatr Child Health. 2022 Oct 12. 

A 14-Year-Old Boy With Neck Pain, Fevers, and Diffuse Erythematous Rash.

Recker A, et al. Pediatrics. 2022 Oct 1;150(4):e2022056508. 

A 14-Year-Old Female With Chest Mass, Shortness of Breath, and Hypertension.

Kirkman K, et al. Pediatrics. 2022 Oct 1;150(4):e2021055380. 

Case 33-2022: An 11-Year-Old Girl with Redness of the Eyes.

Cohen EM, et al. N Engl J Med. 2022 Oct 27;387(17):1598-1607. 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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