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Bubble Wrap PLUS – May 2024


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric Journal Club reading list from Professor Jaan Toelen (University Hospitals Leuven) and Dr Anke Raaijmakers (Sydney Children’s Hospital). 

This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research.

This month’s Bubble Wrap Plus provides answers to intriguing questions.

A large cohort study from Sweden, published in JAMA, investigated the possible association between acetaminophen use during pregnancy and the risk of autism, ADHD, and intellectual disability in children. Despite initial findings suggesting a slight increase in risk, further analysis using sibling controls showed no significant association, indicating that familial factors may account for earlier observations of this association. Acetaminophen, a common medication used during pregnancy, does not contribute to these neurodevelopmental disorders when familial confounding is considered.

The J Paediatr Child Health published an Australian multifaceted intervention (including clinician education, parent engagement, and audit feedback) to reduce unnecessary chest CXRs in infants with bronchiolitis. Although pre-post rates appeared to have decreased significantly from 7.9% to 5.4%—the intervention did not really affect CXR ordering practices when adjusting for various factors. The persistence of high CXR rates underscores ongoing challenges in changing clinical behaviours and emphasizes the need for continued education on appropriate diagnostic practices in bronchiolitis.

An interesting study (JAMA Pediatrics) shows the benefits of newborn screening for spinal muscular atrophy (SMA), as initiating disease-modifying therapy earlier improves clinical outcomes. The researchers compared children diagnosed via screening with those diagnosed after clinical symptoms appeared. Results from Germany, Austria, and Switzerland show that early diagnosis through screening substantially improves the likelihood of achieving significant motor milestones (like sitting and walking independently). These findings advocate for expanding newborn screening programs to enhance outcomes for children with SMA.

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Approach to simple kidney cysts in children.

Dell KM, et al. Pediatr Nephrol. 2024 Apr 27. 

Parasitic infections: what do paediatricians need to know?

Eisen S et al. Arch Dis Child. 2024 Apr 16:archdischild-2024-326876. 

Retinopathy of prematurity comes full circle.

Fielder AR, et al. Arch Dis Child Fetal Neonatal Ed. 2024 Apr 11 

Why all newborn hip screening programs have same results-a mini review.

Bm MV, et al. Eur J Pediatr. 2024 Apr 9. 

Long COVID in pediatrics-epidemiology, diagnosis, and management.

Toepfner N, et al. Eur J Pediatr. 2024 Apr;183(4):1543-1553. 

Central nervous system tumours in neonates: what should the neonatologist know?

Toniutti M, et al. Eur J Pediatr. 2024 Apr;183(4):1485-1497. 

Eu- or hypoglycemic ketosis and ketoacidosis in children: a review.

Meoli M, et al. Pediatr Nephrol. 2024 Apr;39(4):1033-1040. 

Inflammatory bowel disease: recent developments.

Ashton JJ, et al. Arch Dis Child. 2024 Apr 18;109(5):370-376. 

Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia.

Ding G et al. Eur J Pediatr. 2024 Apr 18. 

Challenging Dogma in the Treatment of Childhood Infections: Oral Antibiotics and Shorter Durations.

Tanti DC, et al. Pediatr Infect Dis J. 2024 Apr 2.

2.Original clinical studies

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability.

Ahlqvist VH, et al. JAMA. 2024 Apr 9;331(14):1205-1214. 

Physical Fitness and Risk of Mental Disorders in Children and Adolescents.

Chiang HL, et al. JAMA Pediatr. 2024 Apr 29:e240806. 

Improving inpatient paediatric de-labelling of allergies to beta-lactams: a quality improvement study.

Wong J, et al. Arch Dis Child. 2024 Apr 25:archdischild-2023-326533. 

Nasogastric tube feeding under physical restraint of children and young people with mental disorders: a comprehensive audit and case series across paediatric wards in England.

Fuller S et al. Arch Dis Child. 2024 Apr 22:archdischild-2024-327039. 

Parental practices that influence children’s development: how often are they implemented and by whom-results from the NASCITA birth cohort study.

Pandolfini C et al. Eur J Pediatr. 2024 Apr 22. 

Child participation during outpatient consultations: a mixed methods study.

Koenis MM et al. Eur J Pediatr. 2024 Apr 19. 

A silent scream in the pediatric emergency department: child abuse and neglect.

Akkaya B et al. Eur J Pediatr. 2024 Apr 13. 

Respiratory outcomes and survival after unplanned extubation in the NICU: a prospective cohort study from the SEPREVEN trial.

Yager H et al. Arch Dis Child Fetal Neonatal Ed. 2024 Apr 18:fetalneonatal-2023-326679. 

Emergency department discharge practices for children with acute wheeze and asthma: a survey of discharge practice and review of safety netting instructions in the UK and Ireland.

Hannah R et al. Arch Dis Child. 2024 Apr 16:archdischild-2023-326247. 

Associations of excessive internet use, sleep duration and physical activity with school absences: a cross-sectional, population-based study of adolescents in years 8 and 9.

Kosola S, et al. Arch Dis Child. 2024 Apr 16:archdischild-2023-326331. 

Prospective multicenter evaluation of adherence to the Dutch guideline for children aged 0-16 years with fever without a source-febrile illness in children (FINCH) study.

Keuning MW, et al. Eur J Pediatr. 2024 Apr 15. 

Distinguishing Clinical Features of Cannabinoid Hyperemesis Syndrome and Cyclic Vomiting Syndrome: A Retrospective Cohort Study.

Shah M, et al. J Pediatr. 2024 Apr 12:114054. 

Use of neonatal lung ultrasound in European neonatal units: a survey by the European Society of Paediatric Research.

Alonso-Ojembarrena A, et al. Arch Dis Child Fetal Neonatal Ed. 2024 Apr 11 

Preadolescent Suicidal Thoughts and Behaviors: An Intensive Longitudinal Study of Risk Factors.

Thompson RJ et al. J Am Acad Child Adolesc Psychiatry. 2024 Apr 9:S0890-8567(24)00184-9. 

Reducing unwarranted chest x-rays in bronchiolitis: Importance of a robust analysis.

Lawrence J, et al. J Paediatr Child Health. 2024 Apr 10. 

Pulse oximetry signal loss during hypoxic episodes in preterm infants receiving automated oxygen control.

Langanky LO et al. Eur J Pediatr. 2024 Apr 9. 

Association of empiric antibiotic selection and clinical outcomes in hospitalised children with severe orbital infections: a retrospective cohort study.

Krueger C et al. Arch Dis Child. 2024 Apr 8:archdischild-2023-326175. 

Clinical Effectiveness of Newborn Screening for Spinal Muscular Atrophy: A Nonrandomized Controlled Trial.

Schwartz O, et al. JAMA Pediatr. 2024 Apr 8:e240492. 

Transcutaneous bilirubin reliability during and after phototherapy depending on skin color.

Candel-Pau J, et al. Eur J Pediatr. 2024 Apr 6. 

Cerebral Palsy and Motor Impairment after Extreme Prematurity: Prediction of Diagnoses at Ages 2 and 10 Years.

Marinelli T, et al. J Pediatr. 2024 Apr 3:114037

Apnea, Intermittent Hypoxemia, and Bradycardia Events Predict Late-Onset Sepsis in Infants Born Extremely Preterm.

Kausch SL, et al. J Pediatr. 2024 Apr 2;271:114042. 

CPAP Versus NIPPV Postextubation in Preterm Neonates: A Comparative-Effectiveness Study.

Mukerji A et al. Pediatrics. 2024 Apr 1;153(4):e2023064045. 

Are children living with obesity more likely to experience musculoskeletal symptoms during childhood? A linked longitudinal cohort study using primary care records.

Firman N, et al. Arch Dis Child. 2024 Apr 18;109(5):414-421. 

Drawing the abdominal pain: A powerful tool to distinguish between organic and functional abdominal pain.

Opp J, et al. J Pediatr Gastroenterol Nutr. 2024 Apr;78(4):846-852. 

Growth pattern of paediatric patients affected by cow milk protein allergy fed with rice hydrolyzed formula.

Nocerino R, et al. J Pediatr Gastroenterol Nutr. 2024 Apr;78(4):909-917. 

Estimated C-reactive protein (CRP) velocity for rapidly distinguishing bacterial from other etiologies in children presenting to emergency department with remarkably elevated CRP levels.

Cohen N, et al. Eur J Pediatr. 2024 Apr;183(4):1925-1933. 

Home-based fecal calprotectin utilization in a general pediatric gastroenterology clinic.

Schmidt ML, et al. J Pediatr Gastroenterol Nutr. 2024 Apr;78(4):790-799. 

Thickening human milk: the effect of time, temperature, and thickener for infants with dysphagia.

Brooks L, et al. Eur J Pediatr. 2024 Apr;183(4):1839-1848. 

Greater rate of weight loss predicts paediatric hospital admission in adolescent typical and atypical anorexia nervosa.

Brennan C, et al. Eur J Pediatr. 2024 Apr;183(4):1789-1799. 

Association between breakfast skipping and psychosomatic symptoms among Canadian adolescents.

Peprah P, et al. Eur J Pediatr. 2024 Apr;183(4):1607-1617.

3.Guidelines and best evidence

4.Case reports

A 12-Year-old Boy With a Knee Infection.

Verbakel J et al. Pediatr Infect Dis J. 2024 May 1;43(5):483-486. 

Multiple magnet ingestion causing volvulus.

Mander E, et al. Arch Dis Child. 2024 Apr 9:archdischild-2024-326991

Disseminated Abscesses in a Child.

Al Yazidi L, et al. Pediatr Infect Dis J. 2024 Apr 1;43(4):400-401. 

Tinea Versicolor in an Infant.

Ricles VR, et al. J Pediatr. 2024 Apr;267:113920. 

A Rare Case of Endocarditis in a Teenager.

Duval L, et al. Pediatr Infect Dis J. 2024 Apr 1;43(4):e145-e146. 

Hemotympanum with a Basilar Skull Fracture.

Carazo Casas C, et al. N Engl J Med. 2024 Apr 18;390(15):e38. 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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