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Bubble Wrap PLUS – May 2022


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list from Anke Raaijmakers working with Professor Jaan Toelen & his team of the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or simply help you to keep an finger on the pulse of paediatric research.

This month’s list features answers to intriguing questions such as: ‘Does alcohol intoxication lead to QTc prolongation?’, ‘Is ultrasound useful in the workup of suspected cryptorchidism?’, ‘Is a short-course (<48)  intravenous treatment an option for young infants with non-bacteraemic UTI?’, ‘Should we use tape to make button batteries safer before disposal?’ and ‘Should we perform immunological investigations in children with invasive pneumococcal disease?’.

You will find the list is broken down into four sections:

2.Original clinical studies

QTc prolongation in adolescents with acute alcohol intoxication.

de Veld L, et al. Eur J Pediatr. 2022 Apr 28. 

Continued use of scrotal ultrasounds for the workup of undescended testes: Confirmation bias and inaccuracies.

Annick ET, et al. J Paediatr Child Health. 2022 Apr 27. 

Management of intraorbital infections in the pediatric emergency department.

Sorotzky M, et al. Eur J Pediatr. 2022 Apr 27. 

Short-course intravenous antibiotics for young infants with urinary tract infection.

Lawrence J, et al. Arch Dis Child. 2022 Apr 25:archdischild-2021-323554. 

Noninvasive High-Frequency Oscillatory Ventilation vs Nasal Continuous Positive Airway Pressure vs Nasal Intermittent Positive Pressure Ventilation as Postextubation Support for Preterm Neonates in China: A Randomized Clinical Trial.

Zhu X, et al. JAMA Pediatr. 2022 Apr 25. 

Association of Early Life Prescriptions for Antibiotics and Acid Suppressants with Childhood Psychotropic Prescriptions.

Stark CM, et al. J Pediatr. 2022 Apr 20:S0022-3476(22)00345-6. 

Perinatal Inflammatory Biomarkers and Respiratory Disease in Preterm Infants.

Collaco JM, et al. J Pediatr. 2022 Apr 20:S0022-3476(22)00343-2. 

Do pediatricians and nurses recommend vaccines for preterm infants? A survey in Italy.

Napolitano F, et al. J Pediatr. 2022 Apr 19:S0022-3476(22)00341-9. 

Toxoplasma Gondi Infection and Aggression in Autistic Children.

Hamid N, et al. Pediatr Infect Dis J. 2022 Apr 21. 

Button battery taping prevents oesophageal injury.

Wolter NE, et al. J Paediatr Child Health. 2022 Apr 20. 

Implications of an Elevated Nucleated Red Blood Cell Count in Neonates with Moderate to Severe Hypoxic-Ischemic Encephalopathy.

Bahr TM, et al. J Pediatr. 2022 Apr 14:S0022-3476(22)00329-8. 

Otologic Examination Findings In Afebrile Young Infants Clinically Diagnosed With Acute Otitis Media.

McLaren SH, et al. Pediatr Infect Dis J. 2022 Apr 13. 

Screening for Immunodeficiencies in Children With Invasive Pneumococcal Disease: Six-Year Experience From a UK Children’s Hospital.

Bijker EM, et al. Pediatr Infect Dis J. 2022 Apr 13. 

Balance bike injuries: A retrospective chart review.

Oishi T, et al. J Paediatr Child Health. 2022 Apr 12. 

Does the delivery mode affect post-birth neonatal serum C-reactive protein levels? A causal effect analysis.

Kozlovski T, et al. J Paediatr Child Health. 2022 Apr 12. 

Criteria-led discharge for simple appendicitis in children: A pilot study.

Roddis B, et al. J Paediatr Child Health. 2022 Apr 9. 

Dynamic Structural Brain Changes in Anorexia Nervosa: A Replication Study, Mega-analysis, and Virtual Histology Approach.

Bahnsen K, et al. J Am Acad Child Adolesc Psychiatry. 2022 Apr 1:S0890-8567(22)00183-6. 

Management and Outcome of Febrile Infants ≤60 days, With Emphasis on Infants ≤21 Days Old, in Swedish Pediatric Emergency Departments.

Orfanos I, et al. Pediatr Infect Dis J. 2022 Apr 4. 

Cerebrospinal Fluid Shunt Infections: A Multicenter Pediatric Study.

McAlpine A, et al. Pediatr Infect Dis J. 2022 Apr 4. 

Diagnosis and management of urinary tract infections in children aged 2 months to 3 years in the Italian emergency units: the ItaUTI study.

Cenzato F, et al. Eur J Pediatr. 2022 Apr 6. 

Association Between Residential Proximity to Hydraulic Fracturing Sites and Adverse Birth Outcomes.

Cairncross ZF, et al. JAMA Pediatr. 2022 Apr 4:e220306. 

Long COVID (post-COVID-19 condition) in children: a modified Delphi process.

Stephenson T, et al. Arch Dis Child. 2022 Apr 1:archdischild-2021-323624. 

Temporal Association between Influenza Vaccination Coverage and Ambulatory Antibiotic Use in Children.

Younas M, et al. Pediatr Infect Dis J. 2022 Apr 1. 

Improving Vancomycin Stewardship in Critically Ill Children.

Chiotos K, et al. Pediatrics. 2022 Apr 1;149(4):e2021052165. 

Human Metapneumovirus Infection in a Children’s Hospital – It Should Get More Attention.

Hani N, et al. Pediatr Infect Dis J. 2022 Apr 1;41(4):284-289. 

Youth Well-being During the COVID-19 Pandemic.

Blackwell CK, et al. Pediatrics. 2022 Apr 1;149(4):e2021054754. 

Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial.

Nurko S, et al. JAMA Pediatr. 2022 Apr 1;176(4):349-356. 

Association Between Screen Time Exposure in Children at 1 Year of Age and Autism Spectrum Disorder at 3 Years of Age: The Japan Environment and Children’s Study.

Kushima M, et al. JAMA Pediatr. 2022 Apr 1;176(4):384-391. 

Pharmacogenomics and asthma treatment: acceptability to children, families and healthcare professionals.

Parry CM, et al. Arch Dis Child. 2022 Apr;107(4):394-399. 

Monitoring Antibiotic Consumption in Pediatrics. How Close to Reality Are Days of Therapy and Recommended Daily Dose Methods?

Baier J, et al. Pediatr Infect Dis J. 2022 Apr 1;41(4):e126-e132. 

Nasal High-Flow Therapy during Neonatal Endotracheal Intubation.

Hodgson KA, et al. N Engl J Med. 2022 Apr 28;386(17):1627-1637. 

Prefusion F Protein-Based Respiratory Syncytial Virus Immunization in Pregnancy.

Simões EAF, et al. N Engl J Med. 2022 Apr 28;386(17):1615-1626. 

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Following Extubation on Liberation From Respiratory Support in Critically Ill Children: A Randomized Clinical Trial.

Ramnarayan P, et al. JAMA. 2022 Apr 26;327(16):1555-1565.

3.Guidelines and best evidence

4.Case reports

A 4-month-old female infant with breast development and virilisation.

Fujiwara S, et al. J Paediatr Child Health. 2022 Apr 28. 

Hypereosinophilia, Abdominal Pain, and Diarrhea: Anisakiasis, a Difficult Diagnosis in a Child.

Trotta D, et al. Pediatr Infect Dis J. 2022 Apr 27. 

Congenital Syphilis and the Prozone Phenomenon: Case Report.

Catueno S, et al. Pediatr Infect Dis J. 2022 Apr 21. 

Guillain-Barré Syndrome Associated With Acute Toxoplasmosis in a 3-Year-old Boy.

Satostegui M, et al. Pediatr Infect Dis J. 2022 Apr 6:INF.0000000000003550.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.

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