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Bubble Wrap Plus – May 2020


Here is a new Bubble Wrap Plus, our monthly paediatric Journal Club List provided by Professor Jaan Toelen & his team of the University Hospitals in Leuven (Belgium). This comprehensive list of ‘articles to read’ comes from 34 journals, including Pediatrics, The Journal of Pediatrics, Archives of Disease in Childhood, JAMA Pediatrics, Journal of Paediatrics and Child Health, NEJM, and many more. For a summary on COVID-19, we refer to our collection of COVID resources and in particular, our weekly updated literature summary.

This month’s list features answers to intriguing questions such as: ‘What are atypical presentations of Covid-19 in children?’, ‘Can cycled phototherapy substantially reduce total treatment time?’, ‘Is saline nasal irrigation useful for acute upper respiratory tract infections?’, ‘What is the clinical value of Factor XIII in HSP?’ and ‘ Is iron supplementation useful for breath holding spells?’.

You will find the list is broken down into four sections:


1.Reviews and opinion articles

Anorexia Nervosa.

Mitchell JE, et al. N Engl J Med. 2020 Apr 2;382(14):1343-1351.

Reflexes that impact spontaneous breathing of preterm infants at birth: a narrative review.

Kuypers K, et al. Arch Dis Child Fetal Neonatal Ed. 2020 Apr 29.

Nickel Allergic Contact Dermatitis: Identification, Treatment, and Prevention.

Silverberg NB, et al. Pediatrics. 2020 Apr 27.

Prevention of iron-deficiency anemia in infants and toddlers.

Sundararajan S, et al. Pediatr Res. 2020 Apr 24.

Peanut Allergy: New Advances and Ongoing Controversies.

Abrams EM, et al. Pediatrics. 2020 Apr 17.

The medical evaluation of prepubertal children with suspected sexual abuse.

Smith T, et al. Paediatr Child Health. 2020 Apr;25(3):180-194.

Bronchopulmonary dysplasia: A review of the pulmonary sequelae in the post-surfactant era.

Haggie S, et al. J Paediatr Child Health. 2020 Apr 8.

Possible causes for decreased susceptibility of children to coronavirus.

Zhu L, et al. Pediatr Res. 2020 Apr 8.

Tuberculosis treatment in children: The changing landscape.

Huynh J, et al. Paediatr Respir Rev. 2020 Feb 26.

State-of-the-Art Renal Imaging in Children.

Viteri B, et al. Pediatrics. 2020 Feb;145(2).

Vesicoureteral reflux is it important to find?

Hewitt I, et al. Pediatr Nephrol. 2020 Apr 22.

2. Original clinical studies

Atypical presentation of COVID-19 in young infants.

Nathan N, et al. Lancet. 2020 Apr 27.

Vulnerable Youth and the COVID-19 Pandemic.

Silliman Cohen RI, et al. Pediatrics. 2020 Apr 28.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review.

Castagnoli R, et al. JAMA Pediatr. 2020 Apr 22.

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.

Oxley TJ, et al. N Engl J Med. 2020 Apr 28

Lung biopsy in children: when is it useful?

Chan CD, et al. Arch Dis Child. 2020 Apr 29.

Migraine in children under 6 years of age: A long-term follow-up study.

Marchese F, et al. Eur J Paediatr Neurol. 2020 Apr 17.

Prevalence of Continuous Pulse Oximetry Monitoring in Hospitalized Children With Bronchiolitis Not Requiring Supplemental Oxygen.

Bonafide CP, et al. JAMA. 2020 Apr 21;323(15):1467-1477.

Is Carbon Dioxide Insufflation During Endoscopy in Children as Safe and as Effective as we Think?

Dike CR, et al. J Pediatr Gastroenterol Nutr. 2020 Apr 14.

Antibiotic prophylaxis for prevention of urinary tract infections in the first year of life in children with vesicoureteral reflux diagnosed in the workup of antenatal hydronephrosis: a systematic review.

Leigh J, et al. Pediatr Nephrol. 2020 Apr 30.

Application of PECARN rules would significantly decrease CT rates in a Dutch cohort of children with minor traumatic head injuries.

Niele N, et al. Eur J Pediatr. 2020 Apr 28.

Hospitalizations and Deaths Associated with EVALI.

Werner AK, et al. N Engl J Med. 2020 Apr 23;382(17):1589-1598.

E-cigarette or Vaping Product Use-Associated Lung Injury (EVALI) Without Respiratory Symptoms.

Matta P, et al. Pediatrics. 2020 Apr 21.

E-cigarette Product Characteristics and Subsequent Frequency of Cigarette Smoking.

Barrington-Trimis JL, et al. Pediatrics. 2020 Apr 6. pii: e20191652.

Cardiopulmonary resuscitation in pediatric pectus excavatum patients – where is the heart?

Jang YE, et al. Paediatr Anaesth. 2020 Apr 16.

Cycled Phototherapy Dose-Finding Study for Extremely Low-Birth-Weight Infants: A Randomized Clinical Trial.

Arnold C, et al. JAMA Pediatr. 2020 Apr 27.

Delayed menarche in girls with chronic kidney disease and the association with short stature.

Kim HS, et al. Pediatr Nephrol. 2020 Apr 27.

Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial.

Kumar A, et al. J Pediatr. 2020 Apr 23.

Effect of blue LED phototherapy centered at 478 nm versus 459 nm in hyperbilirubinemic neonates: a randomized study.

Ebbesen F, et al. Pediatr Res. 2020 Apr 26.

Blue LED phototherapy in preterm infants: effects on an oxidative marker of DNA damage.

van der Schoor LWE, et al. Arch Dis Child Fetal Neonatal Ed. 2020 Apr 8.

Reduced Antibiotic Exposure by Serial Physical Examinations in Term Neonates at Risk of Early-onset Sepsis.

Vatne A, et al. Pediatr Infect Dis J. 2020 May;39(5):438-443.

BMI changes through childhood: the impact on puberty, linear growth and hormonal regulation.

Tryggestad JB, et al. Pediatr Res. 2020 Apr 16.

Factor XIII as a potential predictor of severe gastrointestinal involvement in Henoch Schoenlein purpura: A case study research.

d’Angelo DM, et al. J Paediatr Child Health. 2020 Apr 15.

Trimethoprim-Sulfamethoxazole Associated Drug-Induced Liver Injury in Pediatrics: A Systematic Review.

Burgos RM, et al. Pediatr Infect Dis J. 2020 Apr 8.

Iron Supplementation for the Treatment of Breath-Holding Spells: A Systematic Review and Meta-Analysis.

Hecht EM, et al. Clin Pediatr (Phila). 2020 Apr 13:9922820915893.

Respiratory pathogens and acute chest syndrome in children with sickle cell disease.

Ploton MC, et al. Arch Dis Child. 2020 Apr 8.

High flow nasal cannula as respiratory support in treating infant bronchiolitis: a systematic review.

Moreel L, et al. Eur J Pediatr. 2020 May;179(5):711-718

4. Case Reports

Teenager With Abdominal Pain and Decreased Appetite.

Clore J, et al. Pediatrics. 2020 Apr 29.

A Case of a Mediastinal Mass in a Teenager Causing Chest Pain, Difficulty Breathing, and Emesis: A Rare Complication of a Relatively Common Disease.

Chang TF, et al. Clin Pediatr (Phila). 2020 Apr 26:9922820915888.

A 6-week-old male infant with persistent leukocytosis.

Matthews R, et al. Paediatr Child Health. 2020 Apr;25(3):131-133.

Thyroid Storm in a Toddler Presenting as a Febrile Seizure.

Ladd JM, et al. Pediatrics. 2020 Feb;145(2).

Self-Limiting Sternal Tumor of Childhood: A “Do Not Touch” Lesion.

Moreira BL, et al. J Pediatr. 2020 Apr 17.


If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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