Skip to content

Bubble Wrap PLUS – June 2024


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric Journal Club reading list from Professor Jaan Toelen (University Hospitals Leuven) and Dr Anke Raaijmakers (Sydney Children’s Hospital). 

This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research.

In this month’s list of the journal club, we would like to draw your attention to some studies that caught our interest. 

The Lancet published a trial on a new vaccination technique that may overcome barriers to immunisation, such as strict cold-chain requirements, poor infrastructure, and concern about vaccine wastage. Microneedle patches (MNPs) are a new technological innovation to improve vaccine coverage, especially in developing countries. This (phase 1/2) RCT showed similar seroconversion rates between traditional vaccines and the MNPs. Importantly, the safety and tolerability of the MNPs were excellent.

However, there is still work to do: We need implementation studies in hard-to-reach locations, success rates with non-medical staff delivering and administering the MNPs, and expanding study participant eligibility to include broader age groups (particularly 6–9-month-olds) and vulnerable populations such as malnourished children. This will improve the generalisability of the findings. We are looking forward to being updated on these exciting new opportunities. 

Out-of-hospital cardiac arrest is associated with poorer outcomes, so training as many people as possible in the community in cardiopulmonary resuscitation (CPR) has the potential to close this gap, but manikins and courses are not cheap. Peixoto-Pino and colleagues investigated the option of training primary school children in a low-cost way. They used a (low-cost, ~€5) manikin with visual qualitative feedback and compared the results with the skills acquired by practice on a conventional manikin.

School children were allocated to the lost-cost (LoCoMan) or standard manikin (control) group. All participants practised for one hands-on skill session before performing a post-test on an instrumented CPR manikin. The control group achieved better chest compression depth, while the LoCoMan group showed more compressions with adequate chest recoil. The authors conclude that the approach can incentivise teachers to teach CPR and provide education outside the formal environment. Similar training initiatives (i.e. MiniPOP and others) have achieved great results. 

A frequently asked question in paediatric practice: “Look at this photo, are the stools of my baby supposed to be green/dark/mustard colour/almost black?” The study by Solasaari et al. described the defecation patterns of healthy infants in the first months of life. Parents completed weekly online questionnaires about feeding, gastrointestinal function, and crying. They found that defecation frequency was highest at the age of 3 weeks.

Not surprisingly, stool was most often yellow or light brown and nearly black stools were reported in the first week of life in 3.4%. Nearly half of the infants had green stool colour for at least one week. One in ten reported blood in stools, and one in twenty had recurrent episodes. Hard stools were rare (≤ 1%). The authors conclude that there is a large spectrum of defecation patterns in healthy term infants. 

We hope this month’s list will keep you interested in the progress in our field!

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Primary Ciliary Dyskinesia. 

Wee WB, et al. Pediatrics. 2024 May 2:e2023063064. 

Cliff or bridge: breaking up with the paediatric healthcare system. 

Baumbusch J. Paediatr Child Health. 2023 Sep 4;29(2):84-86. 

Medical cannabis for children: Evidence and recommendations. 

Kelly LE, et al. Paediatr Child Health. 2024 Apr 5;29(2):104-121. 

Evolution of Gene Therapy for Inborn Errors of Immunity. 

Somekh I, et al. JAMA Pediatr. 2024 May 20. 

On the lookout for post-streptococcal complications in the UK. 

Healy J, et al. Arch Dis Child. 2024 May 17;109(6):522-523. 

Managing menstruation for medically complex paediatric patients. Gray SH. Arch Dis Child. 2024 May 29:archdischild-2024-326968.

2.Original clinical studies

SARS-CoV-2 Infection in Children Less Than Forty Days Hospitalized in Belgium Between 2020 and 2022. 

Demey M, et al. Pediatr Infect Dis J. 2024 May 16. 

Measles and rubella vaccine microneedle patch: new hope to reach the unreached children. 

Coulborn RM, Danet C, Alsalhani A. Lancet. 2024 May 11;403(10439):1825-1827. 

A measles and rubella vaccine microneedle patch in The Gambia: a phase 1/2, double-blind, double-dummy, randomised, active-controlled, age de-escalation trial. 

Adigweme I, et al. Lancet. 2024 May 11;403(10439):1879-1892. 

Headache and Other Factors Modifying Cerebrospinal Fluid Opening Pressure in Pediatric Patients. 

Espitia Segura OM, et al. J Child Neurol. 2024 May 15:8830738241252209. 

Effect of Low-Dose Iron Supplementation on Early Development in Breastfed Infants: A Randomized Clinical Trial. 

Svensson L, et al. JAMA Pediatr. 2024 May 13:e241095. 

Antibiotic Overtreatment of Presumed Urinary Tract Infection among Children with Spina Bifida. 

Kucherov V, et al. J Pediatr. 2024 May 9:114092

Assessing the quality of chest compressions with a DIY low-cost manikin (LoCoMan) versus a standard manikin: a quasi-experimental study in primary education. 

Peixoto-Pino L, et al. Eur J Pediatr. 2024 May 14. 

Timing and dosage of intrapartum prophylactic penicillin for preventing early-onset group B streptococcal disease: assessing maternal and umbilical cord blood concentration. 

Nielsen SY, et al. Arch Dis Child Fetal Neonatal Ed. 2024 May 10:fetalneonatal-2024-326986. 

Maternal Vitamin D Supplementation and Infantile Rickets: Secondary Analysis of a Randomized Trial. 

Lautatzis ME, et al. Pediatrics. 2024 May 10:e2023063263. 

No safe time window in malrotation and volvulus: A consecutive cohort study. 

Gibson A, et al. J Paediatr Child Health. 2024 May 7. 

Increasing the Use of Enteral Antibiotics in Hospitalized Children With Uncomplicated Infections. 

Molloy MJ, et al. Pediatrics. 2024 May 7;153(6):e2023062427. 

Long-Term Cardiovascular Outcomes in Children and Adolescents With Hypertension. 

Robinson CH, et al. JAMA Pediatr. 2024 May 6. 

Preferences in Clinical Care of Individuals With Differences of Sex Development. 

Avanceña ALV, et al. Pediatrics. 2024 May 3:e2023064207. 

Potential causes of delays in paediatric perforated appendicitis: A prospective interview study. 

Trinidad S, et al. J Paediatr Child Health. 2024 May 2. 

Premature newborns with intraventricular hemorrhage do not have vasospasm pattern by cranial Doppler ultrasound: A pilot study. 

Rodriguez-Fanjul J, et al. Eur J Pediatr. 2024 May 25. 

Determinants of antibiotic prescription in children with adenovirus respiratory tract infections. 

Buonsenso D, et al. Eur J Pediatr. 2024 May 23. 

Viral load in hospitalized infants with respiratory syncytial virus bronchiolitis: a three-way comparative analysis. 

Golan-Tripto I, et al. Eur J Pediatr. 2024 May 23. 

Effect of Social Distancing Caused by Heavy Snowfall on Seasonal Influenza Epidemic in a Local Region in Japan. 

Yamada K, et al. Pediatr Infect Dis J. 2024 May 20. 

Smartphone use and well-being of adolescent girls: a population-based study. 

Kosola S, et al. Arch Dis Child. 2024 May 21:archdischild-2023-326521. 

Outcomes of children diagnosed antenatally with sex chromosome aneuploidies. 

Angley E, et al. J Paediatr Child Health. 2024 May 21. 

Outcome in pediatric celiac disease is independent of the diagnostic approach in patients with high antibody levels. 

Klöti S, et al. J Pediatr Gastroenterol Nutr. 2024 May 20. 

Continuous versus intermittent phototherapy in treatment of neonatal jaundice: a randomized controlled trial. 

Demirel HN, et al. Eur J Pediatr. 2024 May 20. 

Bowel function in a prospective cohort of 1052 healthy term infants up to 4 months of age. 

Solasaari T, et al. Eur J Pediatr. 2024 May 31

Investigating the air quality surrounding new schools in England: polluted playgrounds and school buildings are a source of avoidable harm. 

Mahfouz Y, et al. Arch Dis Child. 2024 May 17;109(6):483-487. 

Subcutaneous Administration of a Monoclonal Antibody to Prevent Malaria. 

Kayentao K, et al. N Engl J Med. 2024 May 2;390(17):1549-1559. 

Neurodevelopmental Outcomes After Late Preterm Antenatal Corticosteroids: The ALPS Follow-Up Study. 

Gyamfi-Bannerman C, et al. JAMA. 2024 May 21;331(19):1629-1637. 

Neonatal Hypoglycemia and Neurocognitive Function at School Age: A Prospective Cohort Study. 

Wei X, et al. J Pediatr. 2024 May 28:114119. 

Sepsis Huddles in the Neonatal Intensive Care Unit: A Retrospective Cohort Study of Late-onset Infection Recognition and Severity Assessment. 

Coggins SA, et al. J Pediatr. 2024 May 28:114117. 

Early Child Opportunity Index Mobility, Recurrent Wheezing, and Asthma: A Population-based Prospective Cohort Study. 

Tyris J, et al. J Pediatr. 2024 May 28:114121. 

Patterns of Adverse Childhood Experiences and Neurocognitive Development. 

Yu J, et al. JAMA Pediatr. 2024 May 28:e241318. 

Video versus Direct Laryngoscopy for Urgent Intubation of Newborn Infants. 

Geraghty LE, et al. N Engl J Med. 2024 May 30;390(20):1885-1894. 

Age and Probability of Spontaneous Umbilical Hernia Closure. He K, et al. JAMA Pediatr. 2024 May 1;178(5):497-498.

3.Guidelines and best evidence

World Health Organization (WHO) guideline on the complementary feeding of infants and young children aged 6-23 months 2023: A multisociety response. 

ESPGHAN, EAP et al. J Pediatr Gastroenterol Nutr. 2024 May 14. 

Treatment of Childhood Brucellosis: A Systematic Review. 

Lanza Galvão E, et al. Pediatr Infect Dis J. 2024 May 15. 

Relaxation Therapy and Human Milk Feeding Outcomes: A Systematic Review and Meta-Analysis. 

Levene I, et al. JAMA Pediatr. 2024 May 6:e240814. 

How consistent are the key recommendations, and what is the quality of guidelines and expert consensus regarding paediatric cow’s milk protein allergy? 

Li T, et al. Eur J Pediatr. 2024 May 29. doi: 10.1007/s00431-024-05622-3. 

The management of very mild and mild asthma in preschoolers, children, and adolescents. 

Yang CL, et al. Paediatr Child Health. 2024 Apr 5;29(2):122-132. 

Breastfeeding and risk of food allergy and allergic rhinitis in offspring: a systematic review and meta-analysis of cohort studies. 

Ding Y, et al. Eur J Pediatr. 2024 May 21. 

Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization. 

Shattock AJ, et al. Lancet. 2024 May 25;403(10441):2307-2316. 

Does This Infant Have a Dislocated Hip? The Rational Clinical Examination Systematic Review. 

Singh A, et al. JAMA. 2024 May 14;331(18):1576-1585. 

Comparison of parent or caregiver-completed development screening tools with Bayley Scales of Infant Development: a systematic review and meta-analysis. 

Balasubramanian H, et al. Arch Dis Child. 2024 May 29:archdischild-2023-326771. 

Correlations between ambient air pollution and the prevalence of hospitalisations and emergency room visits for respiratory diseases in children: a systematic review. 

de Souza AP, et al. Arch Dis Child. 2024 May 29:archdischild-2023-326214. 

Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials. Yang WC, et al. Eur J Pediatr. 2024 May 29. doi: 10.1007/s00431-024-05568-6.

4.Case reports

Blastocystis hominis-ASSOCIATED ACUTE APPENDICULAR PERITONITIS IN A 9-YEAR-OLD BOY: A Case Report and a Comprehensive Review of the Literature. 

Arredondo Montero J, et al. Pediatr Infect Dis J. 2024 May 10. 

A Pediatric Case of Encephalopathy With Hypoglycemia Induced by Coxsackievirus A4 Infection. 

Ishii M, et al. Pediatr Infect Dis J. 2024 May 10.

Intestinal spirochetosis in an immunocompetent pediatric patient. 

Segura S, Lowichik A, Patel R. J Pediatr Gastroenterol Nutr. 2024 May 13. 

Lipschutz’s acute genital ulcers in a toddler: An unusual presentation of Epstein-Barr virus infection. 

Setiawan J, et al. J Paediatr Child Health. 2024 May 7. 

An unusual case of nephrotic syndrome. 

Wildes DM, et al. Pediatr Nephrol. 2024 May 23. 

Clubbing and hypoxia in an adolescent male. 

Bradford J, Connett GJ. Arch Dis Child. 2024 May 17;109(6):482. 

A non-healing perianal ulceration. 

Chan CJ, et al. J Paediatr Child Health. 2024 May 30. 

Cerebriform nevus sebaceous in an infant: an unusual age of presentation. Satapathy S, et al. Arch Dis Child. 2024 May 29:archdischild-2024-327227.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.

    View all posts


No data was found

Leave a Reply

Your email address will not be published. Required fields are marked *