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Bubble Wrap PLUS – January


Happy New Year! Most of us have a long list of good intentions for the new year. We hope that keeping up with literature in 2021 is one of them. Here is a new Bubble Wrap Plus, our monthly paediatric Journal Club List provided by Professor Jaan Toelen of the University Hospitals in Leuven (Belgium). This comprehensive list of ‘articles to read’ comes from 34 journals, including Pediatrics, The Journal of Pediatrics, Archives of Disease in Childhood, JAMA Pediatrics, Journal of Paediatrics and Child Health, NEJM, and many more.

This month’s list features answers to intriguing questions such as: ‘Is child abuse more prevalent during the pandemic?’, ‘Can the smartphone replace the Bristol Stool Chart?’, ‘Does ‘one hour’ matter in giving antibiotics in septic shock?’, ‘Does social distancing lead to fewer URTIs?’, ‘Are ketones useful at triage?’ and ‘Should we worry about invasive infections in children with OMA?’.

You will find the list is broken down into four sections:

2. Original clinical studies

Physiological responses to facemask application in newborns immediately after birth.

Gaertner VD, et al. Arch Dis Child Fetal Neonatal Ed. 2020 Dec 9

Kawasaki Disease Shock Syndrome versus Septic Shock: Early Differentiating Features Despite Overlapping Clinical Profiles.

Power A, et al. J Pediatr. 2020 Dec 5:S0022-3476(20)31482-7.

Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media.

McLaren SH, et al. Pediatrics. 2020 Dec 7:e20201571.

Invasive Bacterial Infections in Afebrile Infants With Otitis Media: Worry Less but Still Worry.

Ravera J, et al. Pediatrics. 2020 Dec 7:e2020039602.

Machine Learning Supports Automated Digital Image Scoring of Stool Consistency in Diapers.

Ludwig T, et al. J Pediatr Gastroenterol Nutr. 2020 Dec 1.

Use of insulin pump therapy is associated with reduced hospital-days in the long-term: a real-world study of 48,756 pediatric patients with type 1 diabetes.

Auzanneau M, et al. Eur J Pediatr. 2020 Dec 1.

Prescription of acid inhibitors in infants: an addiction hard to break.

Levy EI, et al. Eur J Pediatr. 2020 Dec;179(12):1957-1961.

Use of anti-reflux medications in infants under 1 year of age: a retrospective drug utilization study using national prescription reimbursement data.

O’Reilly D, et al. Eur J Pediatr. 2020 Dec;179(12):1963-1967.

Fool me once… treatment exposure to achieve remission in pediatric IBD.

Van Limbergen JE, et al. Eur J Pediatr. 2020 Dec;179(12):1921-1924.

Infliximab in young paediatric IBD patients: it is all about the dosing.

Jongsma MME, et al. Eur J Pediatr. 2020 Dec;179(12):1935-1944.


Diarrheal Deaths After the Introduction of Rotavirus Vaccination in 4 Countries.

Paternina-Caicedo A, et al.Pediatrics. 2020 Dec 30:e20193167.

Emergency Visits and Hospitalizations for Child Abuse During the COVID-19 Pandemic.

Kaiser SV, et al. Pediatrics. 2020 Dec 30:e2020038489.

Association Between Abnormal Fetal Head Growth and Autism Spectrum Disorder.

Regev O, et al. J Am Acad Child Adolesc Psychiatry. 2020 Dec 27:S0890-8567(20)32215-2.

High flow in children with respiratory failure: A randomised controlled pilot trial – A paediatric acute respiratory intervention study.

Franklin D, et al. J Paediatr Child Health. 2020 Dec 30.

Early Skin-to-skin Care with a Polyethylene Bag for Neonatal Hypothermia: A Randomized Clinical Trial.

Travers CP, et al. J Pediatr. 2020 Dec 26:S0022-3476(20)31574-2.

Atypical bartonellosis in children: What do we know?

Lemos AP, et al. J Paediatr Child Health. 2020 Dec 10.

Alternative Cerebral Fuels in the First Five Days in Healthy Term Infants: The Glucose in Well Babies (GLOW) Study.

Harris DL, et al. J Pediatr. 2020 Dec 26:S0022-3476(20)31573-0.

Improving Toddlers’ Healthy Eating Habits and Self-regulation: A Randomized Controlled Trial.

Nix RL, et al. Pediatrics. 2020 Dec 28:e20193326.

Bench-top comparison of thermometers used in newborn infants.

Dunne EA, et al. Arch Dis Child Fetal Neonatal Ed. 2020 Dec 28:fetalneonatal-2020-320123.

Pediatric Emergency Department Visits at US Children’s Hospitals During the COVID-19 Pandemic.

DeLaroche AM, et al. Pediatrics. 2020 Dec 23:e2020039628.

Sustained Lung Inflations During Neonatal Resuscitation at Birth: A Meta-analysis.

Kapadia VS, et al. Pediatrics. 2020 Dec 23:e2020021204.

Association between Baseline Cortisol Serum Concentrations and the Effect of Prophylactic Hydrocortisone in Extremely Preterm Infants.

Renolleau C, et al. J Pediatr. 2020 Dec 23:S0022-3476(20)31567-5.

Delayed Administration of Antibiotics beyond the First Hour of Recognition is Associated with Increased Mortality Rates in Children with Sepsis/Severe Sepsis and Septic Shock.

Sankar J, et al. J Pediatr. 2020 Dec 23:S0022-3476(20)31545-6.

Association of Cesarean Delivery with Childhood Hospitalization for Infections before 13 Years of Age.

Auger N, et al. J Pediatr. 2020 Dec 21:S0022-3476(20)31546-8.

Effect of a Sepsis Screening Algorithm on Care of Children with False-Positive Sepsis Alerts.

Baker AH, et al. J Pediatr. 2020 Dec 21:S0022-3476(20)31543-2.

Rates of Presentation, Treatments and Serious Neurologic Disorders Among Children and Young Adults Presenting to US Emergency Departments With Headache.

Ramgopal S, et al. J Child Neurol. 2020 Dec 24:883073820979137.

COVID-19 in children treated with immunosuppressive medication for kidney diseases.

Marlais M, et al. Arch Dis Child. 2020 Dec 21:archdischild-2020-320616.

Audit on awake anorectal manometry: tolerability in children.

Athanasakos E, et al. Arch Dis Child. 2020 Dec 21:archdischild-2020-321083.

A Graded Approach to Intravenous Dextrose for Neonatal Hypoglycemia Decreases Blood Glucose Variability, Time in the Neonatal Intensive Care Unit, and Cost of Stay.

Sen S, et al. J Pediatr. 2020 Dec 15:S0022-3476(20)31507-9.

Association of Childhood Growth Hormone Treatment With Long-term Cardiovascular Morbidity.

Tidblad A, et al. JAMA Pediatr. 2020 Dec 21:e205199.

Cardiovascular Disease in Former Pediatric Recipients of Growth Hormone: Another Look at Growth Hormone Safety.

Grimberg A. JAMA Pediatr. 2020 Dec 21:e205232.

Deamidated Gliadin Antibodies: Do They Add to Tissue Transglutaminase-IgA Assay in Screening For Celiac Disease?

Abdulrahim A, et al. J Pediatr Gastroenterol Nutr. 2020 Dec 16;Publish Ahead of Print.

Acute Kidney Injury Associated with Late-Onset Neonatal Sepsis: A Matched Cohort Study.

Coggins SA, et al. J Pediatr. 2020 Dec 16:S0022-3476(20)31505-5.

Autism spectrum disorder and kidney disease.

Clothier J, et al. Pediatr Nephrol. 2020 Dec 19.

Bronchopulmonary dysplasia and postnatal growth following extremely preterm birth.

Dassios T, et al. Arch Dis Child Fetal Neonatal Ed. 2020 Dec 17:fetalneonatal-2020-320816.

Long-Term Survival and Causes of Death in Children with Trisomy 21 After Congenital Heart Surgery.

Peterson JK, et al. J Pediatr. 2020 Dec 23:S0022-3476(20)31568-7.

Follow-up Blood Cultures in Children With Staphylococcus aureus Bacteremia.

Cardenas-Comfort C, et al. Pediatrics. 2020 Dec;146(6):e20201821.

Motor Impairment in Children With Congenital Heart Defects: A Systematic Review.

Bolduc ME, et al. Pediatrics. 2020 Dec;146(6):e20200083.

Hospitalised infants due to falls aged less 12 months in New South Wales from 2002 to 2013.

Cooray N, et al. J Paediatr Child Health. 2020 Dec;56(12):1885-1890.

Risk of traumatic intracranial haemorrhage in children with bleeding disorders.

Bressan S, et al. J Paediatr Child Health. 2020 Dec;56(12):1891-1897.

Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome – Is It Related to Ethnicity? An Israeli Multicenter Cohort Study.

Amarilyo G, et al. J Pediatr. 2020 Dec;227:268-273.

Association Between Fat Mass in Early Life and Later Fat Mass Trajectories.

de Fluiter KS, et al. AMA Pediatr. 2020 Dec 1;174(12):1141-1148.

Complementary and Alternative Medicine Use in Pediatric Functional Abdominal Pain Disorders at a Large Academic Center.

Ciciora SL, et al. J Pediatr. 2020 Dec;227:53-59.e1.

Effect of Social Distancing Due to the COVID-19 Pandemic on the Incidence of Viral Respiratory Tract Infections in Children in Finland During Early 2020.

Kuitunen I, et al. Pediatr Infect Dis J. 2020 Dec;39(12):e423-e427.

Universal screening of high-risk neonates, parents, and staff at a neonatal intensive care unit during the SARS-CoV-2 pandemic.

Cavicchiolo ME, et al. Eur J Pediatr. 2020 Dec;179(12):1949-1955.

Risk Factors for Orthostatic Hypertension in Children.

Hu Y, et al. J Pediatr. 2020 Dec;227:212-217.e1.

Neurodevelopmental outcomes after moderate to severe neonatal hypoglycemia.

Rasmussen AH, et al. Eur J Pediatr. 2020 Dec;179(12):1981-1991.

The utility of ketones at triage: a prospective cohort study.

Durnin S, et al. Arch Dis Child. 2020 Dec;105(12):1157-1161.

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates.

Walsh EE, et al. N Engl J Med. 2020 Dec 17;383(25):2439-2450.

Does detection of fetal growth restriction improve neonatal outcomes?

Selvaratnam RJ, et al. J Paediatr Child Health. 2020 Dec 14.

Children and young adults with spinal muscular atrophy treated with nusinersen.

Osredkar D, et al. Eur J Paediatr Neurol. 2020 Dec 4;30:1-8.

Effect of Early Targeted Treatment of Ductus Arteriosus with Ibuprofen on Survival Without Cerebral Palsy at 2 years in Infants with Extreme Prematurity: A Randomized Clinical Trial.

Rozé JC, et al. J Pediatr. 2020 Dec 8:S0022-3476(20)31488-8.

Time Course of Coronary Artery Aneurysms in Kawasaki Disease.

Tsuda E, et al. J Pediatr. 2020 Dec 7:S0022-3476(20)31484-0.

4. Case reports

Chewing gum bezoar as an unexpected cause of acute intestinal obstruction.

Sinopidis X, et al. J Paediatr Child Health. 2020 Dec 29.

Unusual presentation of coeliac disease with idiopathic intracranial hypertension.

Pathmanandavel K, et al. J Paediatr Child Health. 2020 Dec 21.

Case 39-2020: A 29-Month-Old Boy with Seizure and Hypocalcemia.

Virkud YV, et al. N Engl J Med. 2020 Dec 17;383(25):2462-2470.

A Gut Feeling: Abdominal Symptoms as an Initial Presentation of EVALI.

Wekon-Kemeni C, et al. Pediatrics. 2020 Dec 30:e20193834.

Sequential Retinal Hemorrhages in an Asymptomatic Child.

Ho DK, et al. J Pediatr. 2020 Dec;227:319-320.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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