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Bubble Wrap PLUS – January 2022


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list from Anke Raaijmakers working with Professor Jaan Toelen & his team of the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or simply help you to keep a finger on the pulse of paediatric research.

Happy New Year! Most of us have a long list of good intentions for the new year. We hope that keeping up with literature in 2022 is one of them. Here is a new Bubble Wrap Plus, our monthly paediatric Journal Club List provided by Professor Jaan Toelen of the University Hospitals in Leuven (Belgium). This comprehensive list of ‘articles to read’ comes from 34 journals, including Pediatrics, The Journal of Pediatrics, Archives of Disease in Childhood, JAMA Pediatrics, Journal of Paediatrics and Child Health, NEJM, and many more.

This month’s list features answers to intriguing questions such as: ‘Is there a need for specific legislation on small magnets?’, ‘Does grade IV vesicoureteral reflux increase the odds of febrile recurrence of UTI?’, ‘Can a gastrointestinal PCR-panel reduce inappropriate AB prescription in cases with infectious diarrhoea?‘, ‘Does dextrose gel influence the neonatal gut microbiome?’ and ‘Can intranasally administered surfactant improve otitis media?’. Also, the chickenpox review article is highly recommended!

You will find the list is broken down into four sections:

1.Reviews and opinion articles

The pediatric common variable immunodeficiency – from genetics to therapy: a review.

Szczawinska-Poplonyk A, et al. Eur J Pediatr. 2021 Dec 23.

Neuroradiological Mimics of Periventricular Leukomalacia.

Reddy N, et al. J Child Neurol. 2021 Dec 22:8830738211026052.

Rickets guidance: part I-diagnostic workup.

Haffner D, et al. Pediatr Nephrol. 2021 Dec 15.

Dietary exposures and allergy prevention in high-risk infants.

Abrams EM, et al. Paediatr Child Health. 2021 Dec 27;26(8):504-505.

Why do they call chickenpox chickenpox?

Watson DAR. J Paediatr Child Health. 2021 Dec;57(12):2026-2028.

2.Original clinical studies

Suicide Risk in Adolescents During the COVID-19 Pandemic.

Lantos JD, et al. Pediatrics. 2021 Dec 31:e2021053486.

Psychiatric Outcomes, Functioning, and Participation in Extremely Low Gestational Age Newborns at Age 15 Years.

Frazier JA, et al. J Am Acad Child Adolesc Psychiatry. 2021 Dec 27:S0890-8567(21)02093-1.

Ultrasound guided catheter tip location in neonates: a prospective cohort study.

Grasso F, et al. J Pediatr. 2021 Dec 28:S0022-3476(21)01266-X.

Paediatric ultrasound-guided vascular access: Experiences and outcomes from an emergency department educational intervention.

Calcutt T, et al. J Paediatr Child Health. 2021 Dec 29.

Decade of the dangers of multiple magnet ingestion in children: A retrospective review.

Chang A, et al. J Paediatr Child Health. 2021 Dec 30.

Treatment and coronary artery aneurysm formation in Kawasaki disease: a per-day risk analysis.

van Stijn D, et al. J Pediatr. 2021 Dec 27:S0022-3476(21)01261-0.

Home-hospital care for children with acute illnesses: A 2-year follow-up study.

Cabrera López IM, et al. J Paediatr Child Health. 2021 Dec 30.

Functional brain maturation and sleep organisation in neonates with congenital heart disease.

Hermans T, et al. Eur J Paediatr Neurol. 2021 Dec 14;36:115-122.

Risk factors for the development of febrile recurrences in children with a history of urinary tract infection.

Hum S, et al. J Pediatr. 2021 Dec 22:S0022-3476(21)01244-0.

mRNA Coronavirus-19 Vaccine-Associated Myopericarditis in Adolescents: A Survey Study.

Kohli U, et al. J Pediatr. 2021 Dec 21:S0022-3476(21)01231-2.

Adolescent/Young Adult Long-acting Reversible Contraception: Experience from a Multisite Adolescent Medicine Collaborative.

Pitts S, et al. J Pediatr. 2021 Dec 21:S0022-3476(21)01238-5.

Gonadotropin-Releasing Hormone Analogs for Treatment of Central Precocious Puberty in Children Less than 2 Years of Age.

Gohil A, et al. J Pediatr. 2021 Dec 20:S0022-3476(21)01236-1.

Early antibiotic exposure and adverse outcomes in very preterm infants at low risk of early-onset sepsis: the EPIPAGE-2 cohort study.

Letouzey M, et al. J Pediatr. 2021 Dec 20:S0022-3476(21)01223-3.

Immunogenicity and safety of routine vaccines in children and adolescents with rheumatic diseases on immunosuppressive treatment – a systematic review.

Keller M, et al. Eur J Pediatr. 2021 Dec 22:1-34.

Impact of house dust mite-driven asthma on children’s school performance and activity.

Gómez C, et al. Eur J Pediatr. 2021 Dec 21:1-8.

Risk Factors for Severe COVID-19 in Children.

Woodruff RC, et al. Pediatrics. 2021 Dec 22:e2021053418.

Improved Detection of Child Maltreatment with Routine Screening in a Tertiary Care Pediatric Hospital.

Suresh S, et al. J Pediatr. 2021 Dec 17:S0022-3476(21)01185-9.

Severity of bronchopulmonary dysplasia and neurodevelopmental outcome at two and five years corrected age.

Katz TA, et al. J Pediatr. 2021 Dec 17:S0022-3476(21)01196-3.

High healthcare use at age five in a European cohort of children born very preterm.

Seppänen AV, et al. J Pediatr. 2021 Dec 15:S0022-3476(21)01177-X.

Clinical impact of a gastrointestinal PCR panel in children with infectious diarrhoea.

Truong J, et al. Arch Dis Child. 2021 Dec 17:archdischild-2021-322465.

Inhaled Corticosteroids Alone and in Combination With Long-Acting β2 Receptor Agonists to Treat Reduced Lung Function in Preterm-Born Children: A Randomized Clinical Trial.

Goulden N, et al. JAMA Pediatr. 2021 Dec 13:e215111.

Duration of Antibiotic Therapy in Neonatal Gram-negative Bacterial Sepsis-10 Days versus 14 Days: A Randomized Controlled Trial.

Fursule A, et al. Pediatr Infect Dis J. 2021 Dec 7.

Effects of tactile stimulation on spontaneous breathing during face mask ventilation.

Gaertner VD, et al. Arch Dis Child Fetal Neonatal Ed. 2021 Dec 3:fetalneonatal-2021-322989.

Effect of prophylactic dextrose gel on the neonatal gut microbiome.

St Clair SL, et al. Arch Dis Child Fetal Neonatal Ed. 2021 Dec 2:fetalneonatal-2021-322757.

The Childhood Vaccination Schedule and the Lack of Association With Type 1 Diabetes.

Glanz JM, et al. Pediatrics. 2021 Dec 1;148(6):e2021051910.

IQ in Autism Spectrum Disorder: A Population-Based Birth Cohort Study.

Katusic MZ, et al. Pediatrics. 2021 Dec 1;148(6):e2020049899.

Intranasal Surfactant for Acute Otitis Media: A Randomized Trial.

Muniz GB, et al. Pediatrics. 2021 Dec 1;148(6):e2021051703.

Preventing Home Medication Administration Errors.

Yin HS, et al. Pediatrics. 2021 Dec 1;148(6):e2021054666.

Antibiotic Use in Term and Near-Term Newborns.

Mundal HS, et al. Pediatrics. 2021 Dec 1;148(6):e2021051339.

Rotavirus Vaccine Safety and Effectiveness in Infants With High-Risk Medical Conditions.

van Dongen JAP, et al. Pediatrics. 2021 Dec 1;148(6):e2021051901.

Incidence and Age- and Sex-Specific Differences in the Clinical Presentation of Children and Adolescents With Avoidant Restrictive Food Intake Disorder.

Katzman DK, et al. JAMA Pediatr. 2021 Dec 1;175(12):e213861.

Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial.

NICUSeq Study Group, et al. JAMA Pediatr. 2021 Dec 1;175(12):1218-1226.

Screen Time in the Coronavirus 2019 Era: International Trends of Increasing Use Among 3- to 7-Year-Old Children.

Ribner AD, et al. J Pediatr. 2021 Dec;239:59-66.e1.

Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2 Without Recurrence of Multisystem Inflammatory Syndrome in Children.

Buddingh EP, et al. Pediatr Infect Dis J. 2021 Dec 1;40(12):e491-e492.

Delayed Bronchiolitis Epidemic in French Primary Care Setting Driven by Respiratory Syncytial Virus: Preliminary Data from the Oursyn Study, March 2021.

Rybak A, et al. Pediatr Infect Dis J. 2021 Dec 1;40(12):e511-e514.

Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma.

Bacharier LB, et al. N Engl J Med. 2021 Dec 9;385(24):2230-2240.

Protection against Covid-19 by BNT162b2 Booster across Age Groups.

Bar-On YM, et al. N Engl J Med. 2021 Dec 23;385(26):2421-2430.

Screening and Interventions to Prevent Dental Caries in Children Younger Than 5 Years: US Preventive Services Task Force Recommendation Statement.

US Preventive Services Task Force, Davidson KW, et al. JAMA. 2021 Dec 7;326(21):2172-2178.

3.Guidelines and best evidence

Importance of COVID-19 Vaccination in Children: viewpoint and recommendations of the Union of European National Societies of Pediatrics.

Pettoello-Mantovani M, et al. J Pediatr. 2021 Dec 29:S0022-3476(21)01273-7.

Systematic Review and Meta-analysis: Screening Tools for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.

Mulraney M, et al. J Am Acad Child Adolesc Psychiatry. 2021 Dec 23:S0890-8567(21)02084-0.

Sixth Nerve Palsy in Children Etiology, Long-Term Course, and a Diagnostic Algorithm.

Hanna FA, et al. J Child Neurol. 2021 Dec 8:8830738211035912.

Do Rotavirus Strains Affect Vaccine Effectiveness? A Systematic Review and Meta-analysis.

Cates JE, et al. Pediatr Infect Dis J. 2021 Dec 1;40(12):1135-1143.

4.Case reports

“A boy with Herculean appearance”.

Wright S, et al. J Pediatr. 2021 Dec 22:S0022-3476(21)01246-4.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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