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Bubble Wrap PLUS for November 2021


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list from Anke Raaijmakers, working with Professor Jaan Toelen and his team at the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or help you to keep an finger on the pulse of paediatric research.

This month’s list features answers to intriguing questions such as: ‘Can postnatal pertussis be prevented by antenatal vaccination?’, ‘Is probiotics supplementation in healthy children indicated?’, ‘Are correction factors/formulas useful in case of traumatic lumbar puncture?’, ‘How often do parents use paracetamol and ibuprofen in children with fever?’ and ‘Is intranasal oxytocin useful in children with ASS?’.

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Microbiome and paediatric gut diseases.

Gerasimidis K, et al. Arch Dis Child. 2021 Oct 29:archdischild-2020-320875.

Impact of intrapartum antibiotics on the infant gastrointestinal microbiome: a narrative review.

Diamond L, et al. Arch Dis Child. 2021 Oct 29:archdischild-2021-322590.

COVID-19 in children: I. Epidemiology, prevention and indirect impacts.

Howard-Jones AR, et al. J Paediatr Child Health. 2021 Oct 13.

COVID-19 in children. II: Pathogenesis, disease spectrum and management.

Howard-Jones AR, et al. J Paediatr Child Health. 2021 Oct 25.

Deciding with children.

Massie J. Arch Dis Child. 2021 Oct 22:archdischild-2021-323048.

Biologics for Asthma and Allergic Skin Diseases in Children.

De Keyser HH, et al. Pediatrics. 2021 Oct 18:e2021054270.

The pediatric urobiome in genitourinary conditions: a narrative review.

Cole E, et al. Pediatr Nephrol. 2021 Oct 15.

A Pediatrician, a Resident, and a Medical Student Walk Into a Clinic: The Role of Humor in Clinical Teaching.

Dudas RA, et al. Pediatrics. 2021 Oct 15:e2021053044.

Is this as good as it gets? Implications of an asymptotic mortality decline and approaching the nadir in pediatric intensive care.

Moynihan KM, et al. Eur J Pediatr. 2021 Oct 1.

Should all infants with delayed umbilical cord separation be investigated for leucocyte adhesion deficiency?

Reynolds S, et al. Arch Dis Child. 2021 Oct 1:archdischild-2020-321313.

Review of atrial fibrillation for the general paediatrician.

Taylor LE, et al. J Paediatr Child Health. 2021 Oct;57(10):1564-1571.

Low von Willebrand Factor in Children and Adolescents: A Review.

Srivaths L, et al. JAMA Pediatr. 2021 Oct 1;175(10):1060-1067.

National Pediatric Experience With Virtual Interviews: Lessons Learned and Future Recommendations.

Frohna JG, et al. Pediatrics. 2021 Oct;148(4):e2021052904.

2.Original clinical studies

Preseptal and Orbital Cellulitis: Analysis of Clinical, Laboratory and Imaging Findings of 123 Pediatric Cases From Turkey.

Bülbül L, et al. Pediatr Infect Dis J. 2021 Oct 26.

Neonatal Seizure Management – Is the Timing of Treatment Critical?

Pavel AM, et al. J Pediatr. 2021 Oct 6:S0022-3476(21)00961-6.

Pertussis Disease and Antenatal Vaccine Effectiveness in Australian Children.

Quinn HE, et al. Pediatr Infect Dis J. 2021 Oct 26.

Randomized Trial to Increase Speech Sound Differentiation in Infants Born Preterm.

Richard C, et al. J Pediatr. 2021 Oct 25:S0022-3476(21)01028-3.

Ventilatory Strategies in Infants With Established Severe Bronchopulmonary Dysplasia: A Multicenter Point Prevalence Study.

McKinney RL, et al. J Pediatr. 2021 Oct 25:S0022-3476(21)01029-5.

Factors associated with admission of children to an intensive care unit and readmission to hospital within 28 days of discharge: A population-based study.

Bond DM, et al. J Paediatr Child Health. 2021 Oct 27.

Cohort study of congenital complete heart block among preterm neonates: a single-center experience over a 15-year period.

Hernstadt H, et al. Eur J Pediatr. 2021 Oct 27:1-8.

Probiotic supplementation in healthy pre-school-aged children: Prevalence and predictors.

Irwin N, et al. J Paediatr Child Health. 2021 Oct 25.

Corticosteroids in the Treatment of Pediatric Retropharyngeal and Parapharyngeal Abscesses.

Goenka PK, et al. Pediatrics. 2021 Oct 25:e2020037010.

Corticosteroids for Acute Orbital Cellulitis.

Leszczynska MA, et al. Pediatrics. 2021 Oct 25:e2021050677.

Educational Priorities for Providing End-of-Life Care: Parent Perspectives.

Arora G, et al. Pediatrics. 2021 Oct;148(4):e2021051379.

Clinical Features and Outcomes of Paediatric Patients with Isolated Colonic Crohn’s Disease.

Berger TD, et al. J Pediatr Gastroenterol Nutr. 2021 Oct 21.

Maternal Exposure to Air Pollution Is Associated With Neonatal Jaundice: A Retrospective Cohort Study.

Chen CC, et al. J Pediatr. 2021 Oct 20:S0022-3476(21)01006-4.

Lung ultrasonography decreases radiation exposure in newborns with respiratory distress: a retrospective cohort study.

Tandircioglu UA, et al. Eur J Pediatr. 2021 Oct 23.

SARS-CoV-2 seroprevalence in children and their family members, July-October 2020, Brussels.

Dethioux L, et al. Eur J Pediatr. 2021 Oct 22:1-8.

Clinical utility of correction factors for febrile young infants with traumatic lumbar punctures.

Rogers S, et al. Paediatr Child Health. 2020 Dec 29;26(6):e258-e264.

Haemoglobin and red blood cell reference intervals during infancy.

Larsson SM, et al. Arch Dis Child. 2021 Oct 21:archdischild-2021-321672.

Association of childhood tracheomalacia with bronchiectasis: a case-control study.

Thomas R, et al. Arch Dis Child. 2021 Oct 14:archdischild-2021-322578.

Cranial ultrasound and MRI: complementary or not in the diagnostic assessment of children with congenital CMV infection?

Keymeulen A, et al. Eur J Pediatr. 2021 Oct 12.

Risk factors for mortality in preterm infants with necrotizing enterocolitis: a retrospective multicenter analysis.

Kordasz M, et al. Eur J Pediatr. 2021 Oct 12.

Validity and reliability of the Dutch version of the PedsQL™ 3.0 End Stage Renal Disease Module in children with chronic kidney disease in Belgium.

De Bruyne E, et al. Pediatr Nephrol. 2021 Oct 1.

Decreasing Continuous Positive Airway Pressure Failure in Preterm Infants.

Kakkilaya VB, et al. Pediatrics. 2021 Oct;148(4):e2020014191.

A Text-Based Intervention to Promote Literacy: An RCT.

Chamberlain LJ, et al. Pediatrics. 2021 Oct;148(4):e2020049648.

Six Month Follow-up of Patients With Multi-System Inflammatory Syndrome in Children.

Capone CA, et al. Pediatrics. 2021 Oct;148(4):e2021050973.

Characteristics and Outcomes of Neonates With Blood Stream Infection Due to Listeria monocytogenes.

Ntuli N, et al. Pediatr Infect Dis J. 2021 Oct 1;40(10):917-921.

Acute Abdomen and Appendicitis in 1010 Pediatric Patients With COVID-19 or MIS-C: A Multinational Experience from Latin America.

Yock-Corrales A, et al. Pediatr Infect Dis J. 2021 Oct 1;40(10):e364-e369.

Changing aetiology of paediatric septic arthritis.

Yagupsky P. J Paediatr Child Health. 2021 Oct;57(10):1560-1563.

Medical Admissions Among Adolescents With Eating Disorders During the COVID-19 Pandemic.

Otto AK, et al. Pediatrics. 2021 Oct;148(4):e2021052201.

SARS-CoV-2 Among Infants <90 Days of Age Admitted for Serious Bacterial Infection Evaluation.

Paret M, et al. Pediatrics. 2021 Oct;148(4):e2020044685.

Low In-School COVID-19 Transmission and Asymptomatic Infection Despite High Community Prevalence.

Katz SE, et al. J Pediatr. 2021 Oct;237:302-306.e1.

Community use of paracetamol and ibuprofen in children with fever.

Kloeden B, et al. J Paediatr Child Health. 2021 Oct;57(10):1640-1644.

Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder.

Sikich L, et al. N Engl J Med. 2021 Oct 14;385(16):1462-1473.

Changes in Body Mass Index Among Children and Adolescents During the COVID-19 Pandemic.

Woolford SJ, et al. JAMA. 2021 Oct 12;326(14):1434-1436.

3.Guidelines and best evidence

Surfactant Nebulization to Prevent Intubation in Preterm Infants: A Systematic Review and Meta-analysis.

Gaertner VD, et al. Pediatrics. 2021 Oct 28:e2021052504.

Early versus delayed introduction of human milk fortification in enterally fed preterm infants: A systematic review and meta-analysis.

Hilditch C, et al. J Paediatr Child Health. 2021 Oct 20.

Prescribing drugs to overweight and obese children: Balancing efficacy and safety.

Roy H, et al. Paediatr Child Health. 2021 Jan 21;26(6):e236-e239.

Nature and Children’s Health: A Systematic Review.

Fyfe-Johnson AL, et al. Pediatrics. 2021 Oct;148(4):e2020049155.

4.Case reports

Unusual diaper dermatitis.

Fernandes AC, et al. J Paediatr Child Health. 2021 Oct 26.

Papilloedema and renal failure in an adolescent presenting to the emergency department.

Vega C, et al. J Paediatr Child Health. 2021 Oct 18.

A 4-week-old infant with wheezing and abnormal movements.

Lirette MP, et al. Paediatr Child Health. 2020 Aug 11;26(6):327-329.

Case 32-2021: A 14-Year-Old Girl with Swelling of the Jaw and Hypercalcemia.

Carpenter TO, et al. N Engl J Med. 2021 Oct 21;385(17):1604-1613.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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