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Bubble Wrap PLUS – February 2026

  • , Last updated 04/02/2026

Cite this article as:

. Bubble Wrap PLUS – February 2026, Don't Forget the Bubbles, 2026. Available at: https://doi.org/10.31440/DFTB.67809

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Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric Journal Club reading list from Professor Jaan Toelen (University Hospitals Leuven) and Dr Anke Raaijmakers (Sydney Children’s Hospital). 

This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or keep a finger on the pulse of paediatric research.

These are the highlights:

Profiling Vaccine Attitudes

This large cohort study examined COVID‑19 vaccine hesitancy and actual vaccine uptake in England. Researchers identified eight distinct categories of hesitancy, including concerns about effectiveness, safety, mistrust, and perceived low personal risk. Most forms of hesitancy declined over time and were not strongly linked to persistent refusal. However, hesitancy rooted in low trust or general anti‑vaccine sentiment proved more persistent and predicted lower subsequent vaccination rates.

Fremanezumab for Migraine in Childhood

This randomised, placebo‑controlled trial evaluated fremanezumab, a CGRP‑targeting monoclonal antibody, for the prevention of episodic migraines in children aged 6–17 years. The treatment significantly reduced migraine compared with the placebo. Nearly half of the treated participants achieved at least a 50% reduction in migraine days. Injection‑site redness was the most common side effect, but it was generally mild. A longer follow‑up is needed to confirm long‑term safety.

Infancy Cow’s Milk Protein Allergy  and Toddler Eating Behaviour

This prospective cohort study compared the eating behaviours of children diagnosed with cow’s milk protein allergy in infancy to those of non‑allergic infants. At age four, children with earlier CMPA showed higher levels of food fussiness and a stronger desire to drink, even after adjusting for early life and demographic factors. Other factors associated with fussiness included cesarean delivery, rural residence, early formula substitution, and family atopy. The results suggest that dietary restriction during infancy may have lasting impacts on eating behaviour.

Social Media Use and Adolescent Well‑Being

This large 3‑year cohort study tracked a large number of Australian students to investigate links between after‑school social media use and well‑being. A U‑shaped pattern emerged: both heavy use and complete non‑use were associated with lower well‑being depending on age and sex. Adolescents with the highest use showed significantly higher odds of low well‑being, particularly in girls in early adolescence. However, older adolescents who avoided social media altogether also had higher odds of low well-being. The study shows that the relationship between social media use and well‑being is complex and not linear.

Parenting Intervention and Child Outcomes

The Smart Beginnings model, combining universal pediatric‑based parenting support and targeted home‑based intervention, was tested in a randomised trial of mother‑infant pairs. By age six, children whose families received the intervention showed better academic outcomes across vocabulary, comprehension, reading, and problem‑solving. These effects were mediated through improved parental cognitive stimulation and stronger pre‑academic skills.

We hope that you enjoy the list!

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Symptomatic Vitamin and Nutrient Deficiencies of Autism Spectrum Disorder and the Potential for Treatment.

McAbee GN, et al. J Child Neurol. 2026 Jan 28:8830738251413826. 

Laboratory testing in the poisoned patient.

Hoffman RJ, et al. Arch Dis Child. 2026 Jan 27:archdischild-2025-329429. 

Intrapartum recognition and management of fetal inflammation.

di Pasquo E, Pereira S, Valentini B, Familiari A, Ghi T.Eur J Pediatr. 2026 Jan 15;185(2):81. 

Ethical considerations for semaglutide use in children.

Ryan N, et al. Arch Dis Child. 2026 Jan 6:archdischild-2025-329747. 

Paediatric asthma: from acid to inhalers and biologics – a century of change.

Pillai A, et al. Arch Dis Child. 2026 Jan 5:archdischild-2025-329797. 

From “can we treat?” to “should we treat?”: a narrative review on resuscitation limits at the threshold of viability.

Dani C, et al. Eur J Pediatr. 2026 Jan 3;185(1):51. 

Drugs in focus: Budesonide and its role in paediatric gastrointestinal disorders.

Aziz S, et al. J Pediatr Gastroenterol Nutr. 2026 Jan;82(1):60-69.

2.Original clinical studies

Profiling vaccine attitudes and subsequent uptake in 1·1 million people in England: a nationwide cohort study.

Whitaker M, et al. Lancet. 2026 Jan 24;407(10526):350-362. 

Fremanezumab in Children and Adolescents with Episodic Migraine.

Hershey AD, et al. N Engl J Med. 2026 Jan 15;394(3):243-252. 

Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia.

Chiesa R, et al. N Engl J Med. 2026 Jan 8;394(2):152-165. 

Familial Hypercholesterolemia Screening in Childhood and Early Adulthood: A Cost-Effectiveness Study.

Bellows BK, et al. JAMA. 2026 Jan 13;335(2):140-153. 

Early postnatal changes in serum creatinine from birth to peak and subsequent decline in preterm neonates.

Shimabukuro W, et al. Pediatr Nephrol. 2026 Jan 29. 

Office Hours Versus Non-Office-Hours Admissions to the Paediatric Intensive Care Unit: A Cohort Study on the Impact of Illness Severity on Length of Stay and Mortality.

Pancharoen T, et al. J Paediatr Child Health. 2026 Jan 29. 

Chest compression in newborn infants: what anatomical structures are we compressing?

Chua CT, et al. Arch Dis Child Fetal Neonatal Ed. 2026 Jan 16:fetalneonatal-2025-329582. 

Continued High Levels of Invasive Streptococcus pyogenes Infections in Belgian Children Under 5 Years: Exploring Different Contributing Factors.

Cornelissen L, et al. Pediatr Infect Dis J. 2026 Jan 28. 

Family Connection in Adolescence and Social Connection in Adulthood.

Whitaker RC, et al. JAMA Pediatr. 2026 Jan 26:e255816. 

National outbreak of pertussis in England (2023-2024) in the context of international resurgence.

Ismail SA, et al. Arch Dis Child. 2026 Jan 21:archdischild-2025-329479. 

The incidence and complication rate of pediatric battery ingestion in the Netherlands.

Krom H, et al. Eur J Pediatr. 2026 Jan 21;185(2):94. 

Etiology of Severe Microcephaly in Infants: A Multinational Surveillance Study.

Farrar DS, et al. Pediatrics. 2026 Jan 21:e2025072700. 

Intranasal Treatments for Children With Sleep-Disordered Breathing: The MIST+ Randomized Clinical Trial.

Nixon GM, et al. JAMA Pediatr. 2026 Jan 20:e255717. 

Repetitive Motor Behaviors in Non-Autistic Toddlers.

Moore Hill M, et al. J Pediatr. 2026 Jan 17:114994. 

Effect of cow’s milk protein allergy during infancy on eating behavior at 4 years of age: A cohort study.

Jardim-Botelho A, et al. J Pediatr Gastroenterol Nutr. 2026 Jan 18. 

Necrotizing Enterocolitis and Shunt Survival in Premature Infants with Posthemorrhagic Hydrocephalus: A Hydrocephalus Clinical Research Network Study.

Ravindra VM, et al. J Pediatr. 2026 Jan 16:114985. 

Analysis of infectious complications in paediatric autoimmune neutropenia: a French nationwide retrospective cohort study.

Dhersin R, et al. Arch Dis Child. 2026 Jan 14:archdischild-2025-329509. 

Antibiotics in the first week of life and the association with atopic diseases at ages 9-12: a prospective cohort study.

Carpay NC, et al. Eur J Pediatr. 2026 Jan 14;185(2):76. 

Behavioural determinants of the use of pain-reducing interventions-a survey among professionals who vaccinate children.

van Vreeswijk B, et al. Eur J Pediatr. 2026 Jan 13;185(2):74. 

Social Media Use and Well-Being Across Adolescent Development.

Singh B, et al. JAMA Pediatr. 2026 Jan 12:e255619. 

Influenza Vaccine Effectiveness Among Children With and Without Underlying Conditions.

Hayek H, et al. Pediatrics. 2026 Jan 9:e2025072184. 

Improving Pediatric Concussion Management in the Primary Care Setting.

Rea CJ, et al. Pediatrics. 2026 Jan 7:e2025071049. 

Improving Emergency Department Boarding Time: Balancing Efficiency and Safety.

Vukovic AA, et al. Pediatrics. 2026 Jan 1;157(1):e2025072144. 

Early Parenting Support on Child Development Through Age 6: The Smart Beginnings Model.

Miller EB, et al. Pediatrics. 2026 Jan 1;157(1):e2025072542. 

Worth the Investment: Supporting Families Early for Future Success.

Bodrick NI, et al. Pediatrics. 2026 Jan 1;157(1):e2025074031. 

Continuity and Change of Delayed Sleep Phase From Adolescence to Early Adulthood.

Jääkallio P, et al. Pediatrics. 2026 Jan 1;157(1):e2025071832. 

Smartphone Ownership, Age of Smartphone Acquisition, and Health Outcomes in Early Adolescence.

Barzilay R, et al. Pediatrics. 2026 Jan 1;157(1):e2025072941. 

Prevalence, Characteristics, and Genetic Architecture of Avoidant/Restrictive Food Intake Phenotypes.

Bjørndal LD, et al. JAMA Pediatr. 2026 Jan 1;180(1):45-55. 

The Relationship Between Nightmare Distress and Perceived Pain Intensity in Adolescents: The Role of Depression, Anxiety and Stress as Mediators.

Eid A, et al. J Paediatr Child Health. 2026 Jan;62(1):90-96. 

A Pilot Randomised Controlled Trial of Sublingual Melatonin for Sleep Onset Insomnia in Children With Foetal Alcohol Spectrum Disorder (FASD).

Chandler-Mather N, et al. J Paediatr Child Health. 2026 Jan;62(1):16-22. 

School readiness as a signal of attention-deficit hyperactivity disorder: a population-based cohort study highlighting structural inequalities.

Warburton M, et al. Arch Dis Child. 2026 Jan 19;111(2):167-172. 

A Randomized Controlled Trial of Commercially Available Virtual Reality for Intravenous Cannulation-Related Distress in Children.

Ali S, et al. J Pediatr. 2026 Jan;288:114803.

3.Guidelines and best evidence

Risk factors for avoidant/restrictive food intake disorder in children: A systematic review.

Nowacki R, et al. J Pediatr Gastroenterol Nutr. 2026 Jan 27. 

Infant Outcomes, Risk Factors, and Diagnostic Yield After a Brief Resolved Unexplained Event: A Systematic Review and Meta-Analysis.

Nama N, et al. JAMA Pediatr. 2026 Jan 26:e255858. 

Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: Clinical Report.

Zanelli SA, et al. Pediatrics. 2026 Jan 26:e2025073627. 

Psychosocial Interventions for Disruptive Behavior in Children and Adolescents: A Meta-analysis.

Selph SS, et al. Pediatrics. 2026 Jan 13:e2025072476. 

Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant: Clinical Report.

Parker MG, et al. Pediatrics. 2026 Jan 12:e2025073625. 

Colchicine prophylaxis in pediatric PFAPA: a systematic review.

Dipasquale RF, et al. Eur J Pediatr. 2026 Jan 7;185(1):57. 

Systematic review: Limosilactobacillus reuteri DSM 17938 for preventing antibiotic-associated diarrhoea in children.

Szajewska H, et al. J Pediatr Gastroenterol Nutr. 2026 Jan 4. 

Fractures in Children With Cerebral Palsy: A Systematic Review.

Bentley LA, et al. Pediatrics. 2026 Jan 1;157(1):e2025072946. 

Spotting childhood abdominal tumours: a systematic review and meta-analysis of the clinical presentation.

Ni Cheallaigh L, et al. Arch Dis Child. 2026 Jan 19;111(2):158-166.

4.Case reports

An Oral Human Papillomavirus Lesion in a Neonate: A Clinical Case Report.

Vieira SS, et al. J Paediatr Child Health. 2026 Jan 25. 

Hyperpigmentation in an Infant due to Vitamin B12 Deficiency: Case Report.

Barrantes EV, et al. J Paediatr Child Health. 2026 Jan 21. 

Primary Salmonella Osteomyelitis of the Sternum.

Kleinertz A, et al. Pediatrics. 2026 Jan 22:e2025073145. 

Persistent Nasal Congestion in the Newborn-Think Congenital Syphilis: A Case Report.

Silcock R, et al. J Paediatr Child Health. 2026 Jan 12. 

Uncovering Meckel’s diverticulum: A case of gastrointestinal bleeding in a young child.

Grdina S, et al. J Pediatr Gastroenterol Nutr. 2026 Jan 11. 

When the kidneys speak for the brain: a nephrological presentation of a rare neurological disorder.

Boussetta A, et al. Pediatr Nephrol. 2026 Jan 7

An 11-Year-old Boy With a Headache.

Nuez L, et al. Pediatr Infect Dis J. 2026 Jan 1;45(1):96-98. 

Alopecic Patch in a 10-Year-Old.

Abbenante D, et al. J Paediatr Child Health. 2026 Jan;62(1):146-147.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!

Author

  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium).

    She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants.

    Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus.

    In her free time, she loves to play hockey and hike with her husband and three kids.

    View all posts

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