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Bubble Wrap PLUS – December 2020


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list from Anke Raaijmakers working with Professor Jaan Toelen and his team of the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or simply help you to keep a finger on the pulse of paediatric research.

This month’s list features answers to intriguing questions such as: ‘Is shivering a relevant clinical sign in diagnosing serious bacterial infection?’, ‘Is a bulging fontanelle a good clinical marker for bacterial meningitis?’, ‘What is the value of follow-up blood cultures in children with S aureus bacteraemia?’, ‘What is a recurrence rate of infantile haemangioma after propranolol therapy?’ and ‘What is the prevalence of UTI in infants with URTI?’.

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Understanding primary ciliary dyskinesia and other ciliopathies.

Horani A, et al. J Pediatr. 2020 Nov 23:S0022-3476(20)31452-9.

Opening doors: suggested practice for medical professionals for when a child might be close to telling about abuse.

Marchant R, et al. Arch Dis Child. 2020 Nov 24:archdischild-2020-320093.

‘I just wanted someone to ask me’: when to ask (about child sexual abuse).

Debelle G, et al. Arch Dis Child. 2020 Nov 24:archdischild-2019-317033.

Pediatrician Guidance in Supporting Families of Children Who Are Adopted, Fostered, or in Kinship Care.

Jones VF, et al. Pediatrics. 2020 Nov 23:e2020034629.

When a Family Seeks To Exclude Residents From Their Child’s Care.

Largent EA, et al. Pediatrics. 2020 Nov 5:e2020011007.

Paediatric pancreatic diseases.

Coffey MJ, et al. J Paediatr Child Health. 2020 Nov;56(11):1694-1701.

Coeliac disease in childhood: An overview.

Bishop J, et al. J Paediatr Child Health. 2020 Nov;56(11):1685-1693.

Neonatal liver disease.

Evans HM, et al. J Paediatr Child Health. 2020 Nov;56(11):1760-1768.

Liver disease in the older child.

Ee LC. J Paediatr Child Health. 2020 Nov;56(11):1702-1707.

Diagnosis and management of severe sepsis in the paediatric patient.

Farrell CA. Paediatr Child Health. 2020 Nov 2;25(7):475-476.

Clinical management of sickle cell liver disease in children and young adults.

Kyrana E, et al. Arch Dis Child. 2020 Nov 11:archdischild-2020-319778.

Routine Neuroimaging of the Preterm Brain.

Hand IL, et al. Pediatrics. 2020 Nov;146(5):e2020029082.

Patent Ductus Arteriosus of the Preterm Infant.

Hamrick SEG, et al. Pediatrics. 2020 Nov;146(5):e20201209.

2. Original clinical studies

Shivering has little diagnostic value in diagnosing serious bacterial infection in children: a systematic review and meta-analysis.

Vandenberk M, et al. Eur J Pediatr. 2020 Nov 11.

Adverse Childhood Experiences and School Readiness Among Preschool-Aged Children.

Jackson DB, et al. J Pediatr. 2020 Nov 23:S0022-3476(20)31435-9.

Follow-up Blood Cultures in Children With Staphylococcus aureus Bacteremia.

Cardenas-Comfort C, et al. Pediatrics. 2020 Nov 25:e20201821.

Multisystem Inflammatory Syndrome in Children: An International Survey.

Bautista-Rodriguez C, et al. Pediatrics. 2020 Nov 24:e2020024554.

Implementing a new method of group toilet training in daycare centres: a cluster randomised controlled trial.

Van Aggelpoel T, et al. Eur J Pediatr. 2020 Nov 23.

Clinical Experience with Performing Esophageal Function Testing in Children.

van Lennep M, et al. J Pediatr Gastroenterol Nutr. 2020 Nov 20.

Assessment of 135 794 Pediatric Patients Tested for Severe Acute Respiratory Syndrome Coronavirus 2 Across the United States.

Bailey LC, et al. JAMA Pediatr. 2020 Nov 23.

Randomized Controlled Trial of High-Flow Nasal Cannula in Preterm Infants After Extubation.

Uchiyama A, et al. Pediatrics. 2020 Nov 19:e20201101.

Adenovirus Infection-associated Central Nervous System Disease in Children.

Zhang XF, et al. Pediatr Infect Dis J. 2020 Nov 16.

Cost-effectiveness of Interventions to Increase HPV Vaccine Uptake.

Spencer JC, et al. Pediatrics. 2020 Nov 16:e20200395.

Recurrence rate of infantile hemangioma after oral propranolol therapy.

Frongia G, et al. Eur J Pediatr. 2020 Nov 13.

Somatic symptom and related disorders in a tertiary paediatric hospital: prevalence, reach and complexity.

Wiggins A, et al. Eur J Pediatr. 2020 Nov 13.

Use of a Procalcitonin-guided Antibiotic Treatment Algorithm in the Pediatric Intensive Care Unit.

Katz SE, et al. Pediatr Infect Dis J. 2020 Nov 10.

Abusive Head Trauma in Day Care Centers.

Rey-Salmon C, et al.  Pediatrics. 2020 Nov 10:e2020013771.

Low-dose or no aspirin administration in acute-phase Kawasaki disease: a meta-analysis and systematic review.

Chiang MH, et al. Arch Dis Child. 2020 Nov 10:archdischild-2019-318245.

Bulging fontanelle in febrile infants as a predictor of bacterial meningitis.

Takagi D, et al. Eur J Pediatr. 2020 Nov 9.

Smoking Intention and Progression From E-Cigarette Use to Cigarette Smoking.

Owotomo O, et al. Pediatrics. 2020 Nov 9:e2020002881.

Acute viral bronchiolitis as a cause of pediatric acute respiratory distress syndrome.

Ghazaly MMH, et al. Eur J Pediatr. 2020 Nov 7:1-6.

Predictors of hospital readmission in infants less than 3 months old.

Mace AO, et al. J Paediatr Child Health. 2020 Nov 6.

The Effectiveness of Working Memory Training for Children With Low Working Memory.

Spencer-Smith M, et al. Pediatrics. 2020 Nov 6:e20194028.

Survival and causes of death in extremely preterm infants in the Netherlands.

van Beek PE, et al. Arch Dis Child Fetal Neonatal Ed. 2020 Nov 6:

Longitudinal Association Between Participation in Organized Sport and Psychosocial Development in Early Childhood.

Neville RD, et al. J Pediatr. 2020 Nov 3:S0022-3476(20)31376-7.

In children with a facial port-wine stain, what facial distribution warrants screening for glaucoma?

Mehan A, et al. Arch Dis Child. 2020 Nov 5:archdischild-2020-319931.

New diagnostic approach of the different types of isolated craniosynostosis.

Kronig SAJ, et al. Eur J Pediatr. 2020 Nov 5.

Eating disorders double and acute respiratory infections tumble in hospitalised children during the 2020 COVID shutdown on the Gold Coast.

Jones PD, et al. J Paediatr Child Health. 2020 Nov 5.

Nephrolithiasis during the first 6 months of life in exclusively breastfed infants.

Yılmaz N, et al. Pediatr Nephrol. 2020 Nov 5.

Perceptions of non-successful families attending a weight-management clinic.

Cox JS, et al. Arch Dis Child. 2020 Nov 2:archdischild-2020-319558.

How Are They Doing? Neurodevelopmental Outcomes at School Age of Children Born Following Assisted Reproductive Treatments.

Farhi A, et al. J Child Neurol. 2020 Nov 2:883073820967169.

Breastfeeding and Infections in Early Childhood: A Cohort Study.

Christensen N, et al. Pediatrics. 2020 Nov;146(5):e20191892.

Gut Microenvironment and Bacterial Invasion in Paediatric Inflammatory Bowel Diseases.

Zaidi D, et al. J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):624-632.

The Gut Microbiome and the Triple Environmental Hit Concept of Inflammatory Bowel Disease Pathogenesis.

Kellermayer R, et al. J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):589-595.

Feasibility Study of a New Magnetic Resonance Imaging Mini-capsule Device to Measure Whole Gut Transit Time in Paediatric Constipation.

Sharif H, et al. J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):604-611.

Prevalence of Urinary Tract Infection in Febrile Infants With Upper Respiratory Tract Symptomatology.

Bolivar P, et al. Pediatr Infect Dis J. 2020 Nov;39(11):e380-e382.

Macrolide and Nonmacrolide Resistance with Mass Azithromycin Distribution.

Doan T, et al. N Engl J Med. 2020 Nov 12;383(20):1941-1950.

4. Case reports

Unusual position of the umbilicus in a neonate.

Tsoi SK, et al. Arch Dis Child Fetal Neonatal Ed. 2020 Nov 20:fetalneonatal-2020-321003.

Acholic stools and a small gallbladder: Not always a case of biliary atresia.

Singh H, et al. J Paediatr Child Health. 2020 Nov;56(11):1812-1813.

An unexpected revelation in a child with recurrent severe headaches.

Loke KY, et al. J Paediatr Child Health. 2020 Nov 13.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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