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Bubble Wrap PLUS – August 22


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Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list  from Anke Raaijmakers working with Professor Jaan Toelen & his team of the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or simply help you to keep an finger on the pulse of paediatric research.

This month’s list features answers to intriguing questions such as: ‘Should neonates with a
high risk of hypoglycemia be admitted?
’, ‘Could meconium be protective against early life
’, ‘Is COVID-19 associated with appendicitis?’, and ‘Are paediatricians
better at diagnosing appendicitis in children?

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Paediatric early warning systems: not a simple answer to a complex question.

Roland D, et al. Arch Dis Child. 2022 Jul 22:archdischild-2022-323951. 

Defining Growing Pains: A Scoping Review.

O’Keeffe M, et al. Pediatrics. 2022 Jul 22:e2021052578. 

Genetic testing and screening in children.

Moore AM, Richer J. Paediatr Child Health. 2022 Jul 18;27(4):243-253. 

What do I need to know about liraglutide (Saxenda), the glucagon-like peptide 1 receptor agonist for weight management in children with obesity?

Ryan PM, Hamilton JK. Paediatr Child Health. 2022 Apr 25;27(4):201-202. 

Vision and Concussion: Symptoms, Signs, Evaluation, and Treatment.

Master CL, et al. Pediatrics. 2022 Jul 18:e2021056047. 

Diagnosis and Management of Typhlitis and Neutropenic Enterocolitis in Children with Cancer.

Cross SJ, et al. Pediatr Infect Dis J. 2022 Aug 1;41(8):e326-e328. 

Tympanostomy Tubes for Recurrent Otitis Media.

Lee C, et al. N Engl J Med. 2022 Jul 7;387(1):83-85. 

Strategies for recognizing pneumonia look-alikes.

Drummond D, et al. Eur J Pediatr. 2022 Jul 30.

2.Original clinical studies

Association of growth with neurodevelopment in extremely low gestational age infants: a population-based analysis.

Gerull R, et al. Eur J Pediatr. 2022 Jul 22. 

Neonates at high risk of hypoglycaemia: Is admission necessary?

Dalrymple HM, et al. J Paediatr Child Health. 2022 Jul 22

Outpatient management of moderate cellulitis in children using high-dose oral cephalexin.

Trottier ED, et al. Paediatr Child Health. 2022 May 3;27(4):213-219. 

Meconium-stained amniotic fluid during labor may be a protective factor for the offspring’s childhood wheezing up to 3 years of age: the Japan Environment and Children’s Study.

Murata T, et al. Eur J Pediatr. 2022 Jul 19. 

COVID-19 in children and adolescents: MIS(-C)-taken diagnoses.

van der Steen M, et al. Eur J Pediatr. 2022 Jul 21:1-6. 

Trends in weight loss attempts among children in England.

Ahmad A, et al. Arch Dis Child. 2022 Jul 18:archdischild-2021-323493. 

A randomised trial comparing weaning from CPAP alone with weaning using heated humidified high flow nasal cannula in very preterm infants: the CHiPS study.

Clements J, et al. Arch Dis Child Fetal Neonatal Ed. 2022 Jul 18:fetalneonatal-2021-323636. 

Endoscopy in Infants with Gastrointestinal Bleeding has Limited Diagnostic or Therapeutic Benefit.

Bose P, et al. J Pediatr Gastroenterol Nutr. 2022 Jul 18. 

Melatonin usage in children and young adults, a registry-based cohort study.

Tedroff K, et al. Eur J Paediatr Neurol. 2022 Jul;39:30-34

SARS-CoV-2 Infection Is Not Associated With Pediatric Appendicitis.

Jiang Y, et al. Pediatr Infect Dis J. 2022 Aug 1;41(8):e321-e323. 

Annual Trend in Lumbar Puncture for Infants Younger Than 3 Months Hospitalized With Suspected Serious Bacterial Infection: A Nationwide Inpatient Database Study.

Fuseda Y, et al. Pediatr Infect Dis J. 2022 Aug 1;41(8):631-635. 

Remote Versus In-person Outpatient Clinic Visits and Antibiotic Use Among Children During the COVID-19 Pandemic.

Danino D, et al. Pediatr Infect Dis J. 2022 Aug 1;41(8):636-641. 

Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age.

Tan SHX, et al. N Engl J Med. 2022 Jul 20. 

BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age.

Cohen-Stavi , et al. N Engl J Med. 2022 Jul 21;387(3):227-236. 

Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection.

Boucau J, et al. N Engl J Med. 2022 Jul 21;387(3):275-277. 

Rate of invasive bacterial infection in recently vaccinated young infants with fever without source.

Barreiro-Parrado A, et al. Arch Dis Child. 2022 Jul 27:archdischild-2022-324379. 

The importance of physician speciality on the diagnosis of acute appendicitis and its effect on morbidity in children.

Bostancı SA, Şenel E. J Paediatr Child Health. 2022 Jul 27. 

Reducing antibiotic use in asymptomatic term infants exposed to maternal chorioamnionitis: Predictive role of sepsis risk calculator.

Dsouza V, et al. J Paediatr Child Health. 2022 Jul 23. 

Transanal Irrigation in Children: Treatment Success, Quality of Life, Adherence, Patient Experience, and Independence.

Baaleman DF, et al. J Pediatr Gastroenterol Nutr. 2022 Aug 1;75(2):166-172. 

Physician and Parent Perceptions on Plant-Based Beverages as Substitutes for Cow’s Milk: A Single City Survey.

Fifi AC, et al. J Pediatr Gastroenterol Nutr. 2022 Aug 1;75(2):e25-e29.

3.Guidelines and best evidence

4.Case reports

17-year-old boy with syncope and cardiac arrest.

Tsang J, et al. Paediatr Child Health. 2021 Dec 9;27(4):198-200. 

2-year-old girl with severe eczema and brittle hair.

Peri F, et al. J Paediatr Child Health. 2022 Jul 18. 

Hypereosinophilia, Abdominal Pain, and Diarrhea: Anisakiasis, a Difficult Diagnosis in a Child.

Ludovisi A, et al. Pediatr Infect Dis J. 2022 Aug 1;41(8):e343-e344. 

Case 21-2022: A 17-Year-Old Girl with Fever and Cough.

Ottolini MC, et al. N Engl J Med. 2022 Jul 14;387(2):168-176. 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!

About the authors

  • Anke Paaijmakers is a paediatrician from Belgium, currently working in Antwerp (ZNA Jan Palfijn, Belgium) after completing her fellowship at the Sydney Children’s Hospital. She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and BubbleWrapPlus. In her free time, she loves to hike with her husband and three kids.


High flow therapy – when and how?

Chest compressions in traumatic cardiac arrest

Searching for sepsis

The missing link? Children and transmission of SARS-CoV-2

Don’t Forget the Brain Busters – Round 2

An evidence summary of Paediatric COVID-19 literature


The fidget spinner craze – the good, the bad and the ugly

Parenteral Nutrition

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