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Bubble Wrap PLUS – April 2019


Welcome to April’s Bubble Wrap Plus, our monthly paediatric journal club provided by Professor Jaan Toelen & his team of the University Hospitals in Leuven (Belgium). This comprehensive list of ‘articles to read’ comes from 34 journals, including Pediatrics, The Journal of Pediatrics, Archives of Disease in Childhood, JAMA Pediatrics, Journal of Paediatrics and Child Health, NEJM, and many more.

This month’s list features answers to intriguing questions (and maybe answers) such as: ‘Do pediatricians follow guidelines when managing status epilepticus in children?’, ‘Does antibiotic prophylaxis for UTI lead to fewer non-UTI infections?’, ‘Is intranasal fentanyl safe for procedural pain management in neonates?’ and ‘Does the early or late introduction of allergens change the development of atopic disease?’.

You will find the list broken down into four sections:

1.Reviews and opinion articles

Helicobacter pylori Infection.

Crowe SE. N Engl J Med. 2019 Mar 21;380(12):1158-1165.

Evaluation of the child with global developmental delay and intellectual disability.

Bélanger SA, et al. Paediatr Child Health. 2018 Sep;23(6):403-419.

Closing the Disclosure Gap: Medical Errors in Pediatrics.

Lin M, et al. Pediatrics. 2019 Mar 13.

Why, when, and how to give surfactant.

Jobe AH. Pediatr Res. 2019 Mar 12.

The pathogenesis and management of renal scarring in children with vesicoureteric reflux and pyelonephritis.

Murugapoopathy V, et al. Pediatr Nephrol. 2019 Mar 7.

Communication with children and adolescents about the diagnosis of a life-threatening condition in their parent.

Dalton L, et al. Lancet. 2019 Mar 16;393(10176):1164-1176.

Communication with children and adolescents about the diagnosis of their own life-threatening condition.

Stein A, et al. Lancet. 2019 Mar 16;393(10176):1150-1163.

Paediatric sarcoidosis.

Nathan N, et al.Paediatr Respir Rev. 2019 Feb;29:53-59.

Human milk as “chrononutrition”: implications for child health and development.

Hahn-Holbrook J, et al.Pediatr Res. 2019 Mar 11. 

2. Original clinical studies

Association Between Year of Birth and 1-Year Survival Among Extremely Preterm Infants in Sweden During 2004-2007 and 2014-2016.

Norman M, et al. JAMA. 2019 Mar 26;321(12):1188-1199.

Management of status epilepticus in children prior to medical retrieval: Deviations from the guidelines.

Uppal P, et al. J Paediatr Child Health. 2019 Mar 28.

What Do NICU Fellows Identify as Important for Achieving Competency in Neonatal Intubation?

Brady J, et al.Neonatology. 2019 Mar 19;116(1):10-16.

Achieving Procedural Competency during Neonatal Fellowship Training: Can Trainees Teach Us How to Teach?

Marrs LK, et al.Neonatology. 2019 Mar 19;116(1):17-19.

Impact of Trimethoprim-sulfamethoxazole Urinary Tract Infection Prophylaxis on Non-UTI Infections.

Desai S, et al.Pediatr Infect Dis J. 2019 Apr;38(4):396-397.

Sleep Problems in Children With Autism and Other Developmental Disabilities: A Brief Report.

Valicenti-McDermott M, et al.J Child Neurol. 2019 Mar 17:883073819836541.

A Validated Scale for Assessing the Severity of Acute Infectious Mononucleosis.

Katz BZ, et al.J Pediatr. 2019 Mar 7.

Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants: The SAIL Randomized Clinical Trial.

Kirpalani H, et al. JAMA. 2019 Mar 26;321(12):1165-1175.

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years.

Brustad N, et al. JAMA. 2019 Mar 12;321(10):1003-1005.

High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants.

Rosendahl J, et al. J Pediatr. 2019 Mar 19. pii: S0022-3476(19)30245-8.

Timing of introduction of allergenic solids for infants at high risk.

Abrams EM, et al. Paediatr Child Health. 2019 Feb;24(1):56-57.

The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods.

Greer FR, et al. Pediatrics. 2019 Mar 18. pii: e20190281.

Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial.

Hamada H, et al. Lancet. 2019 Mar 16;393(10176):1128-1137.

Pediatric Celiac Disease and Eosinophilic Esophagitis: Outcome of Dietary Therapy.

Patton T, et al. J Pediatr Gastroenterol Nutr. 2019 Mar 26.

Host and Bacterial Markers that Differ in Children with Cystitis and Pyelonephritis.

Shaikh N, et al. J Pediatr. 2019 Mar 21. pii: S0022-3476(19)30027-7.

Montelukast and Neuropsychiatric Events in Children with Asthma: A Nested Case-Control Study.

Glockler-Lauf SD, et al. J Pediatr. 2019 Mar 21. pii: S0022-3476(19)30198-2.

Physical Fitness, Physical Activity, and the Executive Function in Children with Overweight and Obesity.

Mora-Gonzalez J, et al. J Pediatr. 2019 Mar 19. pii: S0022-3476(18)31745-1.

Does discharging clinically well patients after one hour of treatment impact emergency department length of stay for asthma patients.

Lenko D, et al. J Paediatr Child Health. 2019 Mar 20.

Characterization of Esophageal Motility in Infants with Congenital Diaphragmatic Hernia using High Resolution Manometry.

Rayyan M, et al. J Pediatr Gastroenterol Nutr. 2019 Mar 5.

Effect of metronome guidance on infant cardiopulmonary resuscitation.

Kim CW, et al. Eur J Pediatr. 2019 Mar 8.

Expressions of Gratitude and Medical Team Performance.

Riskin A, Bamberger P, et al. Pediatrics. 2019 Mar 7.

A cohort study of intranasal fentanyl for procedural pain management in neonates.

McNair C, et al. Paediatr Child Health. 2018 Dec;23(8):e170-e175.

Traumatic brain injury in young children with isolated scalp haematoma.

Bressan S, et al. Arch Dis Child. 2019 Mar 4.

Association of Atopic Dermatitis With Sleep Quality in Children.

Ramirez FD, et al. JAMA Pediatr. 2019 Mar 4:e190025.

3. Guidelines and best evidence

Prevention of Drowning.

Denny SA, et al.Pediatrics. 2019 Mar 15.

Lack of Sleep and Sports Injuries in Adolescents: A Systematic Review and Meta-Analysis.

Gao B, et al. J Pediatr Orthop. 2018 Nov 28.

Guidelines for vitamin K prophylaxis in newborns.

Ng E, et al. Paediatr Child Health. 2018 Sep;23(6):394-402.

School, child care and camp exclusion policies for chickenpox: A rational approach.

Bridger NA. Paediatr Child Health. 2018 Sep;23(6):420-427.

4. Case reports

An 11-Month-Old Male With Acute-Onset Left-Sided Facial Paralysis.

Posa M, et al.Clin Pediatr (Phila). 2019 Mar 22:9922819837354.

A Lower-limb Skin Lesion in a 10-year-old Girl.

Koirala A, et al. Pediatr Infect Dis J. 2019 Apr;38(4):e79.

Exercise-Induced Purpura in Children.

Paul SS, et al.Pediatrics. 2019 Apr;143(4).


If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!

Please join us for our next #DFTB_JC on twitter…The DFTB/ADC Journal Club is a monthly collaboration between @DFTBubbles and @ADC_BMJ featuring a FREE access article from the latest issues of Archives of Disease of Childhood.


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.

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