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Bubble Wrap PLUS – April ’24


Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly Paediatric Journal Club reading list from Professor Jaan Toelen (University Hospitals Leuven) and Dr Anke Raaijmakers (Sydney Children’s Hospital). 

This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research.

In this month’s list of the journal club, we would like to draw your attention to some studies that caught our interest. 

Neonates requiring cardiopulmonary resuscitation (CPR) at birth are at risk of neurodevelopmental injury. In a review of resuscitation techniques used in the delivery room published in Archives, researchers explore a technique involving continuous compressions with sustained inflation. The authors call for a randomised controlled trial comparing this ‘new technique’ to the current 3:1 compression-to-ventilation ratio. We will keep this in mind, and if such a study is published, it will be found on our list. 

A case-control study on the association between exposure to air pollutants at home/daycare and the risk of severe bronchiolitis in children under two years was published in the current issue of the European Journal of Pediatrics. Exposure levels were predicted using an interpolation model based on fixed measuring stations. Reassuringly, there were hardly any significant differences in the day-to-day air pollution values between cases and controls. However, medium-term (31 days) exposure was significantly higher in cases than controls in univariate analysis. A logistic regression revealed an association between severe bronchiolitis and increased pollutants at home and in daycare. Although further studies are needed, the study suggests a possible link between severe bronchiolitis and medium-term (air pollution exposure), particularly in daycare. 

Many of us would believe that toddlers’ screen time reduces their word exposure by more than 1000 words per day. A study published this month in JAMA Pediatrics highlights that growing up in a language-rich environment is important for children’s language development. They examined the association between screen time and different measures of parent-child talk (adult words, child vocalizations, and conversational turns) in children aged 12 to 36 months. Advanced speech recognition technology was used to capture their screen time and home language environment on an average 16-hour day. Language Environment Analysis technology provided automated counts of children’s language environment and exposure to electronic noise. The largest decreases were seen at 36 months when an additional minute of screen time was associated with a reduction of 6.6 (95% CI, −11.7 to −1.5) adult words, 4.9 (95% CI, −6.1 to −3.7) child vocalizations, and 1.1 (95% CI, −1.4 to −0.8) conversational turns. Time to turn off those screens at home! 

Urinary tract infections remain a hot topic. This list features an excellent review of biomarkers for urinary tract infection (Ped Neph) and a meta-analysis on the duration of treatment (Eur J Pediatr). Seventeen studies involving 1666 pediatric patients were included. As urinary tract infections cause many febrile episodes, consensus regarding treatment duration could have major health benefits and reduce healthcare costs. There were no significant differences in reinfection and relapse rates within 15 months between short (≤ 5 days) and long-course therapy (≥ seven days), but short-course therapy was associated with a significantly higher failure rate when compared to long-course therapy. 

We hope this month’s list will keep you interested in the progress in our field!

You will find the list is broken down into four sections:

1.Reviews and opinion articles

2.Original clinical studies

Reducing Time to Diagnosis of Autism Spectrum Disorder Using an Integrated Community Specialty Care Model: A Retrospective Study. 

Davis JM et al. J Pediatr. 2024 Mar 14:114009. 

Standard medical therapy with vs. without nebulised magnesium for children with asthma decompensation. 

Cunha L, et al. Eur J Pediatr. 2024 Mar 16. 

Thoracic fluid content (TFC) using electrical cardiometry versus lung ultrasound in the diagnosis of transient tachypnea of newborn. 

El-Fattah NMA, et al. Eur J Pediatr. 2024 Mar 15. 

Gluten-free diet adherence in pediatric celiac patients: Evaluating CDAT questionnaire and test for gluten detection in urine. 

Mello CRLE, da Silva GAP, Lins MTC, Antunes MMC.

J Pediatr Gastroenterol Nutr. 2024 Mar 13. 

Discontinuing absorbent pants in children with bedwetting: a randomized controlled trial. 

Breinbjerg A, et al. Eur J Pediatr. 2024 Mar 12. 

Semaglutide treatment for children with obesity: an observational study. 

van Boxel EJ, et al. Arch Dis Child. 2024 Mar 12:archdischild-2023-326687. 

Air pollution and bronchiolitis: a case-control study in Antwerp, Belgium. 

Van Brusselen D, et al. Eur J Pediatr. 2024 Mar 12.

Continuity of care for children with anorexia nervosa in the Netherlands: a modular perspective. 

Lennips AJ, et al. Eur J Pediatr. 2024 Mar 12. 

Endotracheal Tube Size Adjustments Within Seven Days of Neonatal Intubation. 

Peebles PJ, et al. Pediatrics. 2024 Mar 12:e2023062925. 

Joint Trajectories of Depression and Rumination: Experiential Predictors and Risk of Nonsuicidal Self-Injury. 

Zhu J, et al. J Am Acad Child Adolesc Psychiatry. 2024 Mar 4:S0890-8567(24)00114-X. 

Nut consumption during pregnancy is associated with decreased risk of peer problems in 5-year-old Japanese children. 

Nguyen MQ, et al. J Pediatr Gastroenterol Nutr. 2024 Mar 7. 

Effect of minimization of early blood sampling losses among extremely premature neonates- A randomized clinical trial. 

Balasubramanian H, et al. J Pediatr. 2024 Mar 4:114002. 

Does extremely early expression of colostrum after very preterm birth improve mother’s own milk quantity? A cohort study. 

Levene I, et al. Arch Dis Child Fetal Neonatal Ed. 2024 Mar 4-2023-326784. 

Prevalence of Adolescents Meeting Criteria for Metabolic and Bariatric Surgery. 

Shapiro WL, et al. Pediatrics. 2024 Mar 1;153(3):e2023063916. 

Vitamin D Status in Belgian Children: A Regional Study. 

Van de Walle L, et al. Nutrients. 2024 Feb 26;16(5):657. 

Use of activity trackers to improve blood pressure in young people at risk for cardiovascular disease: a pilot randomized controlled trial. 

Bicki AC, et al. Pediatr Nephrol. 2024 Mar 19. 

Investigating the air quality surrounding new schools in England: polluted playgrounds and school buildings are a source of avoidable harm. 

Mahfouz Y, Tydeman F, Robertson M. Arch Dis Child. 2024 Mar 19:archdischild-2023-325947. 

Universal Free School Meals Policy and Childhood Obesity. 

Localio AM, et al. Pediatrics. 2024 Mar 18. 

Are term breech babies who undergo successful external cephalic version still at increased risk of developmental dysplasia of the hip? 

Stock J, Deshpande SA. Arch Dis Child. 2024 Mar 19;109(4):351-353. 

Utilizing electronic medical records alert to improve documentation of neonatal acute kidney injury. 

Nada A, Bagwell A. Pediatr Nephrol. 2024 Mar 22.

Association of vitamin D with disease severity in infants with bronchiolitis. 

Mittal J, Rajvanshi N, Suvarna K, Kumar P, Goyal JP.

Eur J Pediatr. 2024 Mar 26. doi: 10.1007/s00431-024-05513-7. 

Pharmacovigilance of nephrotoxic drugs in neonates: the Pottel method for acute kidney injury detection in ELBW neonates. 

Dumoulin M, et al. Pediatr Nephrol. 2024 Mar 25. 

Screen Time and Parent-Child Talk When Children Are Aged 12 to 36 Months. 

Brushe ME, et al. JAMA Pediatr. 2024 Mar 4:e236790.

Etiologies and Outcomes of Normocytic Anemia in Children. 

Equitz E, Powers JM, Kirk S. J Pediatr. 2024 Mar 28:114041. 

Machine learning-based analysis for prediction of surgical necrotizing enterocolitis in very low birth weight infants using perinatal factors: a nationwide cohort study. 

Kim SH, et al. Eur J Pediatr. 2024 Mar 30. 

Clinical trial: Randomized controlled trial of linaclotide in children aged 6-17 years with functional constipation. 

Di Lorenzo C, et al. J Pediatr Gastroenterol Nutr. 2024 Mar 27. 

3.Guidelines and best evidence

Climate Change and Children’s Health: Building a Healthy Future for Every Child. 

Ahdoot S, et al. Pediatrics. 2024 Mar 1;153(3):e2023065504. 

Hemoglobin Threshold for Blood Transfusion in Young Children Hospitalized with Iron Deficiency Anemia. 

Sun DLR, et al. J Pediatr. 2024 Mar;266:113878. 

The protective effect of breastfeeding on febrile seizures: a systematic review with meta-analysis. 

Muniz MCR, et al. Eur J Pediatr. 2024 Mar 8. 

Risk factors for infant hearing loss: a meta-analysis. 

Han Y, et al. Eur J Pediatr. 2024 Mar 8. 

Shorter versus longer-course of antibiotic therapy for urinary tract infections in pediatric population: an updated meta-analysis. 

Moreira MVB, et al. Eur J Pediatr. 2024 Mar 7. 

Brief Interventions for Suicidal Youths in Medical Settings: A Meta-Analysis. 

Pitts BH, et al. Pediatrics. 2024 Mar 1;153(3):e2023061881. 

Problem-Solving Skills Training for Parents of Children With Chronic Health Conditions: A Systematic Review and Meta-Analysis. 

Zhou T, et al. JAMA Pediatr. 2024 Mar 1;178(3):226-236

Reclassification of Adolescent Ambulatory Prehypertension and Unclassified Blood Pressures by 2022 American Heart Association Pediatric Ambulatory Blood Pressure Monitoring Guidelines. 

Hill-Horowitz T, et al. J Pediatr. 2024 Mar;266:113895. 

Point-of-care ultrasound to assess degree of dehydration in children: a systematic review with meta-analysis. 

Kołodziej M, Jalali A, Łukasik J. Arch Dis Child. 2024 Mar 19;109(4):275-281 

Primary Care Interventions to Prevent Child Maltreatment: Evidence Report and Systematic Review for the US Preventive Services Task Force. 

Viswanathan M, et al. JAMA. 2024 Mar 19;331(11):959-971. 

Primary Care Interventions to Prevent Child Maltreatment: US Preventive Services Task Force Recommendation Statement. 

Barry MJ, et al. JAMA. 2024 Mar 19;331(11):951-958. 

Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data. 

Wang X, et al. Lancet. 2024 Mar 30;403(10433):1241-1253. 

Born too soon and vulnerable: the disproportionate burden of RSV among preterm babies in LMICs. Torres-Fernandez D, Bassat Q. Lancet. 2024 Mar 30;403(10433):1206-1207.

4.Case reports

A 6-Year-Old Girl With Fever, Weakness, and Ataxia. 

Barbadora J, et al. Pediatrics. 2024 Mar 1;153(3):e2023064171. 

The Challenge of a Strange Rash: Dermatitis Artefacta. 

Pasa Morgan MA, et al. J Pediatr. 2024 Mar;266:113881. 

A Rare Case of COVID-19 Related Acute Necrotizing Encephalopathy With the RANBP2 Mutation in a Pediatric Patient. 

Christou E, et al. Pediatr Infect Dis J. 2024 Mar 1;43(3):e84-e86. 

Laryngeal Tuberculosis in a 7-Year-old Child: A Case Report and Literature Review. 

Siddiqui MJ, et al. Pediatr Infect Dis J. 2024 Mar 1;43(3):e114-e116. 

Green Urine in the Diaper: A Key Indicator for Diagnosing Hemolytic anemia. 

Yaguchi A, et al. J Pediatr. 2024 Mar;266:113856. 

Giardia lamblia Diagnosed During Upper Gastrointestinal Endoscopy: Clinical Manifestation, Histopathologic Findings and the Association With Celiac Disease. 

Hoofien A, Kori M. Pediatr Infect Dis J. 2024 Mar 1;43(3):194-197. 

Acquired Hemophilia: A Rare Complication of Pediatric Idiopathic Multicentric Castleman Disease. 

Appell LE, et al. Pediatrics. 2024 Mar 21:e2023063168. 

Infantile myofibromatosis in a 5-month-old boy. Mohammad O, Jacoby J, Tighe MP. Arch Dis Child. 2024 Mar 19;109(4):347-348.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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