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Bubble Wrap PLUS


Here is a new Bubble Wrap Plus, our monthly paediatric Journal Club List provided by Professor Jaan Toelen of the University Hospitals in Leuven (Belgium). This comprehensive list of ‘articles to read’ comes from 34 journals, including Pediatrics, The Journal of Pediatrics, Archives of Disease in Childhood, JAMA Pediatrics, Journal of Paediatrics and Child Health, NEJM, and many more.

This month’s list features answers to intriguing questions such as: ‘How should we prepare for the 2021 RSV season?’, ‘When does high flow oxygen fail in bronchiolitis?’, ‘Is early tonsillectomy useful for OSA in children?’, ‘Can probiotics reduce the incidence of NEC in preterms?’ and ‘Does reinfection with SARS-CoV-2 lead to a second episode of MISC?’.

You will find the list is broken down into four sections:

Reviews and opinion articles

Update and Progress in Pediatric Sleep Disorders.

DelRosso LM, et al. J Pediatr. 2021 Aug 24:S0022-3476(21)00791-5.

Paediatric genomic testing: Navigating genomic reports for the general paediatrician.

Shah M, et al. J Paediatr Child Health. 2021 Aug 23.

Youth vaping: a review and update on global epidemiology, physical and behavioral health risks, and clinical considerations.

Becker TD, et al. Eur J Pediatr. 2021 Aug 15:1-10.

Low von Willebrand Factor in Children and Adolescents: A Review.

Srivaths L, et al. JAMA Pediatr. 2021 Aug 2.

Group A streptococcal pharyngitis: A practical guide to diagnosis and treatment.

Sauve L, et al. Paediatr Child Health. 2021 Jul 28;26(5):319-320.

Use of Probiotics to Prevent Necrotizing Enterocolitis: Evidence to Clinical Practice.

Razak A, et al. JAMA Pediatr. 2021 Aug 1;175(8):773-774.

Manipulating the neonatal gut microbiome: current understanding and future perspectives.

Wong E, et al. Arch Dis Child Fetal Neonatal Ed. 2021 Aug 25:fetalneonatal-2021-321922.

Original clinical studies

RSV bronchiolitis season 2021 has arrived, so be prepared!

Hussain F, et al. Arch Dis Child. 2021 Aug 19:archdischild-2021-322835.

Examining the interseasonal resurgence of respiratory syncytial virus in Western Australia.

Foley DA, et al. Arch Dis Child. 2021 Aug 25:archdischild-2021-322507.

Risk factors for hospitalisation due to respiratory syncytial virus infection in children receiving prophylactic palivizumab.

Chida-Nagai A, et al. Eur J Pediatr. 2021 Aug 21.

Decreasing delivery room intubations: A quality improvement project.

Jardine L, et al. J Paediatr Child Health. 2021 Aug 27.

Maternal Vaccination and Infant Influenza and Pertussis.

Rowe SL, et al. Pediatrics. 2021 Aug 26:e2021051076.

Predictors of Invasive Herpes Simplex Virus Infection in Young Infants.

Cruz AT, et al. Pediatrics. 2021 Aug 26:e2021050052.

Clinical effects of hypertonic saline boluses in children with severe traumatic brain injury.

Read C, et al. J Paediatr Child Health. 2021 Aug 23.

Sustained Inflation Versus Intermittent Positive Pressure Ventilation for Preterm Infants at Birth: Respiratory Function and Vital Sign Measurements.

Foglia EE, et al. J Pediatr. 2021 Aug 25:S0022-3476(21)00823-4.

Paediatric Residents and Fellows Ethics (PERFEct) survey: perceptions of European trainees regarding ethical dilemmas.

Boer MCD, et al. Eur J Pediatr. 2021 Aug 24.

Infant Deaths From Medical Causes After a Maltreatment Report.

Schneiderman JU, et al. Pediatrics. 2021 Aug 23:e2020048389.

Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination.

Hansen J, et al. Pediatr Infect Dis J. 2021 Aug 20.

The Modified Bristol Stool Form Scale: A Reliable and Valid Tool to Score Stool Consistency in Dutch (Non)Toilet-trained Toddlers.

Wegh CAM, et al. J Pediatr Gastroenterol Nutr. 2021 Aug 1;73(2):210-216.

Preterm or Early Term Birth and Risk of Autism.

Crump C, et al. Pediatrics. 2021 Aug 11:e2020032300.

Cardiorespiratory monitoring of red blood cell transfusions in preterm infants.

Poppe JA, et al. Eur J Pediatr. 2021 Aug 9.

Factors associated with treatment failure of high-flow nasal cannula among children with bronchiolitis: a single-centre retrospective study.

D’Alessandro M, et al. Paediatr Child Health. 2020 Aug 2;26(5):e229-e235.

Impact of initial flow rate of high-flow nasal cannula on clinical outcomes in infants with bronchiolitis.

Ball M, et al. J Paediatr Child Health. 2021 Aug 3.

Nonauscultatory clinical criteria are sensitive for cardiac pathology in low-risk paediatric heart murmurs.

Penslar J, et al. Paediatr Child Health. 2020 Aug 5;26(5):294-298.

Oral Vancomycin as Secondary Prophylaxis for Clostridioides difficile Infection.

Bao H, et al. Pediatrics. 2021 Aug;148(2):e2020031807.

Sleep and Behavior 24 Months After Early Tonsillectomy for Mild OSA: An RCT.

Waters KA, et al. Pediatrics. 2021 Aug;148(2):e2020038588.

Early Tonsillectomy for Mild Obstructive Sleep Apnea: Too Early to Draw Conclusions.

Cooper JN, et al. Pediatrics. 2021 Aug;148(2):e2021050761.

Gut Microbiota in Mexican Children With Acute Diarrhea: An Observational Study.

Toro Monjaraz EM, et al. Pediatr Infect Dis J. 2021 Aug 1;40(8):704-709.

Sexual and Reproductive Health Discussions During Preventive Visits.

Sieving RE, et al. Pediatrics. 2021 Aug;148(2):e2020049411.

Necrotising enterocolitis, late-onset sepsis and mortality after routine probiotic introduction in the UK.

Granger C, et al. Arch Dis Child Fetal Neonatal Ed. 2021 Aug 25:fetalneonatal-2021-322252.

SARS-CoV-2 Antibodies in Breast Milk After Vaccination.

Ramìreza DSR, et al. Pediatrics. 2021 Aug 18:e2021052286.

SARS-CoV-2 RNA and antibody detection in breast milk from a prospective multicentre study in Spain.

Bäuerl C, et al. Arch Dis Child Fetal Neonatal Ed. 2021 Aug 20:fetalneonatal-2021-322463.

Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2 Without Recurrence of Multisystem Inflammatory Syndrome in Children.

Buddingh EP, et al. Pediatr Infect Dis J. 2021 Aug 10.

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant.

Lopez Bernal J, et al. N Engl J Med. 2021 Aug 12;385(7):585-594.

Initial experience of the safety and tolerability of the BNT162b2 (Pfizer-Bio-N-Tech) vaccine in extremely vulnerable children aged 12-15 years.

King H, et al. Arch Dis Child. 2021 Aug 26:archdischild-2021-322655.

Long COVID in Children: Observations From A Designated Pediatric Clinic.

Ashkenazi-Hoffnung L, et al. Pediatr Infect Dis J. 2021 Aug 5.

Guidelines and best evidence

Maternal Adverse Childhood Experiences and Child Behavior Problems: A Systematic Review.

Cooke JE, et al. Pediatrics. 2021 Aug 19:e2020044131.

Reducing asthma hospitalisations in at-risk children: A systematic review.

Chen KYH, et al. J Paediatr Child Health. 2021 Aug 5.

Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old.

Pantell RH, et al. Pediatrics. 2021 Aug;148(2):e2021052228.

Prevention of Drowning.

Denny SA, et al. Pediatrics. 2021 Aug;148(2):e2021052227.

Prevalence and Antimicrobial Resistance of Bacteria in Children With Acute Otitis Media and Ear Discharge: A Systematic Review.

Hullegie S, et al. Pediatr Infect Dis J. 2021 Aug 1;40(8):756-762.

Case reports

Recipe for Disaster: Homemade Formula Leading to Severe Complications in 2 Infants.

Vieira MA, et al. Pediatrics. 2021 Aug 26:e2021050947.

Rediscovering the Physical Exam: Zinc Deficiency in a Preterm Infant.

Zaladonis CA, et al. J Pediatr. 2021 Aug 19:S0022-3476(21)00781-2.

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!


  • Anke Raaijmakers is a paediatric nephrologist, currently working as clinician and researcher in Sydney (Sydney Children’s Hospital, Australia). She did her training in Belgium and Australia and previously worked as general paediatrician and paediatric nephrologist in Antwerp (ZNA Jan Palfijn, Belgium). She is passionate about education, teaching, and research and has completed a PhD on health outcomes of preterm infants. Anke strongly believes in the importance of evidence-based medicine, helping to run journal clubs everywhere she works and the BubbleWrapPlus. In her free time, she loves to play hockey and hike with her husband and three kids.


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