Bubble Wrap PLUS – Dec 18 / Jan 19

Cite this article as:
Anke Raaijmakers. Bubble Wrap PLUS – Dec 18 / Jan 19, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.17802

Can’t get enough of Bubble Wrap? The Bubble Wrap Plus is a monthly paediatric journal club reading list from Anke Raaijmakers working with Professor Jaan Toelen & his team of the University Hospitals in Leuven. This comprehensive list is developed from 34 journals, including major and subspecialty paediatric journals. We suggest this list can help you discover relevant or interesting articles for your local journal club or simply help you to keep an finger on the pulse of paediatric research.

This bumper edition of Bubble Wrap Plus heralds the end of 2018 and a fresh start with 2019 to explore answers to intriguing questions such as: ‘Should children rest after mild traumatic brain injury?’, ‘Is US guided LP superior to standard technique?’, ‘Do we prescribe acid-suppression too often?’, ‘Does e-cigarette use lead to or prevent smoking in adolescents?’ and ‘Should we institute elective replacement of IV cannulas in neonates?’.

You will find the list is broken down into four sections:

1.Reviews and opinion articles

Refeeding in anorexia nervosa.

Bargiacchi A, et al. Eur J Pediatr. 2018 Nov 27.

End-stage kidney disease in infancy: an educational review.

Sanderson KR, et al. Pediatr Nephrol. 2018 Nov 21.

Renal aspects of metabolic acid-base disorders in neonates.

Iacobelli S, et al. Pediatr Nephrol. 2018 Nov 19.

Pain Relief in the Palm of Your Hand: Harnessing Mobile Health to Manage Pediatric Pain.

Hunter JF, et al. Paediatr Anaesth. 2018 Nov 16.

Cerebral palsy: not always what it seems.

Appleton RE, et al. Arch Dis Child. 2018 Nov 9.

Utility of lung ultrasound scanning in neonatology.

Woods PL. Arch Dis Child. 2018 Nov 9.

Early warning scores in paediatrics: an overview.

Chapman SM, et al. Arch Dis Child. 2018 Nov 9.

A narrative review of proteinuria and albuminuria as clinical biomarkers in children.

Larkins NG, et al. J Paediatr Child Health. 2018 Nov 9.

A review of feeding intolerance in critically ill children.

Tume LN, et al. Eur J Pediatr. 2018 Nov;177(11):1675-1683.

Practical Wisdom, Rules, and the Parent-Pediatrician Conversation.

Brudney D. Pediatrics. 2018 Nov;142(Suppl 3):S193-S198.

Understanding and Improving Diagnostic Tests: The Clinician Perspective.

Ng PC. Neonatology. 2018 Dec 21;115(3):189-196

Developmental Dysplasia of the Hip.

Yang S, et al. Pediatrics. 2018 Dec 26.

An approach to the child with a wet cough.

Gilchrist FJ. Paediatr Respir Rev. 2018 Nov 23.

What’s new in autoinflammation?

Ozen S. Pediatr Nephrol. 2018 Dec 14

Antiemetic Drug Use in Children: What the Clinician Needs to Know.

Romano C, et al. J Pediatr Gastroenterol Nutr. 2018 Dec 11

The neuroimaging mimics of abusive head trauma.

Mankad K, et al. Eur J Paediatr Neurol. 2018 Nov 22.

How to give a better lecture.

Isaacs D, et al. J Paediatr Child Health. 2018 Dec;54(12):1290-1291

Circumcision in the Paediatric Patient: A Review of Indications, Technique and Complications.

Sebaratnam DF. J Paediatr Child Health. 2018 Dec;54(12):1404.

Magnetic resonance imaging of the pediatric mediastinum.

Bardo DME, et al. Pediatr Radiol. 2018 Aug;48(9):1209-1222

Whole-body magnetic resonance imaging: techniques and non-oncologic indications.

Greer MC. Pediatr Radiol. 2018 Aug;48(9):1348-1363.

Neuropathological Developments in Sudden Infant Death Syndrome.

Bright FM, et al. Pediatr Dev Pathol. 2018 Nov-Dec;21(6):515-521.

Hypersensitivity reactions to intravenous antibiotics in cystic fibrosis.

Wright MFA, et al. Paediatr Respir Rev. 2018 Jun;27:9-12.

Understanding cardiac shunts.

Joffe DC, et al. Paediatr Anaesth. 2018 Apr;28(4):316-325.

Vaccination in Pregnancy-Recent Developments.

Jones CE, et al. Pediatr Infect Dis J. 2018 Feb;37(2):191-193.

2. Original clinical studies

Risk Stratification of Febrile Infants ≤60 Days Old Without Routine Lumbar Puncture.

Aronson PL, et al. Pediatrics. 2018 Nov 13.

Omission of Lumbar Puncture From Evaluation of Source of Fever in Young Infants.

Baker MD. Pediatrics. 2018 Nov 13.

Drowsy Driving, Sleep Duration, and Chronotype in Adolescents.

Owens JA, et al. J Pediatr. 2018 Nov 2.

The mediating role of sleep in the relationship between Indigenous status and body mass index in Australian school-aged children.

Deacon-Crouch M, et al. J Paediatr Child Health. 2018 Nov 24.

Cardiovascular Autonomic Control Is Altered in Children Born Preterm with Sleep Disordered Breathing.

Thomas B, et al. J Pediatr. 2018 Nov 13.

Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea.

Oliveira FMS, et al. Pediatr Res. 2018 Nov 12.

Does Sleep Matter? Impact on Development and Functioning in Infants.

Mindell JA, et al. Pediatrics. 2018 Nov 12.

Uninterrupted Infant Sleep, Development, and Maternal Mood.

Pennestri MH, et al. Pediatrics. 2018 Nov 12.

Development of sleep patterns in children with obese and normal-weight parents.

Xiu L, et al. J Paediatr Child Health. 2018 Nov 10.

Digital Screen Time and Pediatric Sleep: Evidence from a Preregistered Cohort Study.

Przybylski AK. J Pediatr. 2018 Oct 30.

Non-indicated acid-suppression prescribing in a tertiary paediatric hospital: An audit and costing study.

Riess S, et al. J Paediatr Child Health. 2018 Nov 28.

Screening for Iron Deficiency in Early Childhood Using Serum Ferritin in the Primary Care Setting.

Oatley H, et al. Pediatrics. 2018 Nov 28.

Staff matter too: pilot staff support intervention to reduce stress and burn-out on a neonatal intensive care unit.

D’Urso A, et al. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 26.

Being Overweight or Obese and the Development of Asthma.

Lang JE, et al. Pediatrics. 2018 Nov 26.

Language in 2-year-old children born preterm and term: a cohort study.

Sanchez K, et al. Arch Dis Child. 2018 Nov 23.

Association between exposure to macrolides and the development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis.

Abdellatif M, et al. Eur J Pediatr. 2018 Nov 23.

Towards an individual screening strategy for first-degree relatives of celiac patients.

Wessels MMS, et al. Eur J Pediatr. 2018 Nov;177(11):1585-1592.

Randomised cross-over study of automated oxygen control for preterm infants receiving nasal high flow.

Reynolds PR, et al. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 21.

Comparison of a Smartphone Otoscope and Conventional Otoscope in the Diagnosis and Management of Acute Otitis Media.

Chan KN, et al. Clin Pediatr (Phila). 2018 Nov 21:

Association of Prenatal Exposure to Air Pollution With Autism Spectrum Disorder.

Pagalan L, et al. JAMA Pediatr. 2018 Nov 19.

Efficacy of Lactobacillus-supplemented triple therapy for Helicobacter pylori infection in children: a meta-analysis of randomized controlled trials.

Fang HR, et al. Eur J Pediatr. 2018 Nov 16.

Trends and Predictors of Clostridium difficile Infection among Children: A Canadian Population-Based Study.

El-Matary W, et al. J Pediatr. 2018 Nov 15.

A comparison between the feeding practices of parents and grandparents.

Metbulut AP, et al. Eur J Pediatr. 2018 Dec;177(12):1785-1794.

Assessment of clinical outcome of children with sepsis outside the intensive care unit.

Zallocco F, et al. Eur J Pediatr. 2018 Dec;177(12):1775-1783.

Pediatric residents’ simulation-based training in patient safety during sedation.

Friedman N, et al. Eur J Pediatr. 2018 Dec;177(12):1863-1867.

Association Between Obesity/Overweight and Functional Gastrointestinal Disorders in Children.

Tambucci R, et al. J Pediatr Gastroenterol Nutr. 2018 Nov 15.

Exposure to and use of mobile devices in children aged 1-60 months.

Kılıç AO, et al. Eur J Pediatr. 2018 Nov 6.

Adenovirus-Associated Central Nervous System Disease in Children.

Schwartz KL, et al. J Pediatr. 2018 Nov 6.

Intellectual Disability in Children Conceived Using Assisted Reproductive Technology.

Hansen M, et al. Pediatrics. 2018 Nov 15.

Physiological Effect of Prone Position in Children with Severe Bronchiolitis: A Randomized Cross-Over Study (BRONCHIO-DV).

Baudin F, et al. J Pediatr. 2018 Nov 14.

Influence of Fathers’ Early Parenting on the Development of Children Born Very Preterm and Full Term.

McMahon GE, et al. J Pediatr. 2018 Nov 14.

Clinical recovery in children with uncomplicated appendicitis undergoing non-operative treatment: secondary analysis of a prospective cohort study.

Knaapen M, et al. vEur J Pediatr. 2018 Nov 12.

Maternal obesity and offspring cognition: the role of inflammation.

Monthé-Drèze C, et al. Pediatr Res. 2018 Nov 12.

Child BMI Over Time and Parent-Perceived Overweight.

Wake M, et al. Pediatrics. 2018 Nov 8.

Geographic and socioeconomic predictors of perforated appendicitis: A national Canadian cohort study.

Akhtar-Danesh GG, et al. J Pediatr Surg. 2018 Nov 7.

E-cigarette Use and Subsequent Smoking Frequency Among Adolescents.

Barrington-Trimis JL, et al. Pediatrics. 2018 Nov 5.

Elective replacement of intravenous cannula in neonates-a randomised trial.

Chin LY, et al. Eur J Pediatr. 2018 Nov;177(11):1719-1726.

Are adolescents really being sedentary or inactive when at school? An analysis of sedentary behaviour and physical activity bouts.

da Costa BGG, et al. Eur J Pediatr. 2018 Nov;177(11):1705-1710.

Delivery Room Management of Meconium-Stained Newborns and Respiratory Support.

Chiruvolu A, et al. Pediatrics. 2018 Nov 1.

Appropriate Management of the Nonvigorous Meconium-Stained Neonate: An Unanswered Question.

Wiswell TE. Pediatrics. 2018 Nov 1.

Gestational Age, Health, and Educational Outcomes in Adolescents.

Berry MJ, et al. Pediatrics. 2018 Nov;142(5).

PEG 3350 Versus Lactulose for Treatment of Functional Constipation in Children: Randomized Study.

Jarzębicka D, et al. J Pediatr Gastroenterol Nutr. 2018 Oct 31.

Nuchal Rigidity in Infantile Bacterial Meningitis.

Iio K, et al. J Pediatr. 2018 Oct 30.

Effect of synbiotic supplementation on children with atopic dermatitis: an observational prospective study.

Ibáñez MD, et al. Eur J Pediatr. 2018 Dec;177(12):1851-1858.

Mealtime insulin bolus adherence and glycemic control in adolescents on insulin pump therapy.

Spaans E, et al. Eur J Pediatr. 2018 Dec;177(12):1831-1836.

Performance of Tuberculin Skin Tests and Interferon-γ Release Assays in Children Younger Than 5 Years.

Velasco-Arnaiz E, et al. Pediatr Infect Dis J. 2018 Dec;37(12):1235-1241.

Viral Acute Respiratory Illnesses in Young Infants Increase the Risk of Respiratory Readmission.

Toizumi M, et al. Pediatr Infect Dis J. 2018 Dec;37(12):1217-1222.

Psychosocial functioning of parents of children with heart disease-describing the landscape.

Wray J, et al. Eur J Pediatr. 2018 Dec;177(12):1811-1821.

Changes in bilirubin in infants with hypoxic-ischemic encephalopathy.

Dani C, et al. Eur J Pediatr. 2018 Dec;177(12):1795-1801.

Needle-related pain and distress management during needle-related procedures in children with and without intellectual disability.

Pascolo P, et al. Eur J Pediatr. 2018 Dec;177(12):1753-1760.

Parent experience in the resuscitation room: how do they feel?

Parra C, et al. Eur J Pediatr. 2018 Dec;177(12):1859-1862.

Renal Replacement Therapy in children with severe developmental disability: guiding questions for decision-making.

Willem L, et al. Eur J Pediatr. 2018 Dec;177(12):1735-1743.

Human Parechovirus 1, 3 and 4 Neutralizing Antibodies in Dutch Mothers and Infants and Their Role in Protection Against Disease.

Karelehto E, et al. Pediatr Infect Dis J. 2018 Dec;37(12):1304-1308.

Predictors of grade 3-5 vesicoureteral reflux in infants ≤ 2 months of age with pyelonephritis.

Bahat H, et al. Pediatr Nephrol. 2018 Dec 26.

Prospective associations between television in the preschool bedroom and later bio-psycho-social risks.

Pagani LS, et al. Pediatr Res. 2018 Dec 26.

Trends, Safety, and Recommendations for Caffeine Use in Children and Adolescents.

Temple JL. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):36-45

Efficacy and Safety of EMLA Cream for Pain Control Due to Venipuncture in Infants: A Meta-analysis.

Shahid S, et al. Pediatrics. 2018 Dec 26.

Age-Related Changes in Inferior Vena Cava Dimensions among Children and Adolescent with Syncope.

Shivaram P, et al. J Pediatr. 2018 Dec 21.

Tracing Effects of Parental Discipline on Child Psychopathology: The Devil’s in the Detail.

Wertz J. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):20-21

Disciplinary Parenting Practice and Child Mental Health: Evidence From the UK MillenniumCohort Study.

Rajyaguru P, et al. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):108-116.e2

Clinical Manifestations, Management, and Outcomes of Osteitis/Osteomyelitis Caused by Mycobacterium bovis Bacillus Calmette-Guérin in Children: Comparison by Site(s) of Affected Bones.

Huang CY, et al. J Pediatr. 2018 Dec 18.

Eating disorder or disordered eating: undiagnosed inflammatory bowel disease mimicking eating disorder.

Harris RE, et al. Arch Dis Child. 2018 Dec 19

Cofactors of Pediatric Tinnitus: A Look at the Whole Picture.

Levi J, Basa K, et al. Clin Pediatr (Phila). 2018 Dec 3:9922818816426.

Probing the Irritability-Suicidality Nexus.

Stringaris A, et al. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):18-19.

Pathways of Association Between Childhood Irritability and Adolescent Suicidality.

Orri M, et al. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):99-107.e3.

Non-urgent paediatric emergency department presentation: A systematic review.

Alele FO, et al. J Paediatr Child Health. 2018 Dec 20.

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

Rice GI, et al. N Engl J Med. 2018 Dec 6;379(23):2275-7.

Everything is awesome: Don’t forget the Lego.

Tagg A, et al. J Paediatr Child Health. 2018 Nov 22.

Oral dextrose gel to treat neonatal hypoglycaemia: Clinician survey.

Alsweiler JM, et al. J Paediatr Child Health. 2018 Nov 22.

Symptoms of Feeding Problems in Preterm-born Children at 6 Months to 7 years Old.

Park J, et al. J Pediatr Gastroenterol Nutr. 2018 Dec 14

Physical activity after mild traumatic brain injury: What are the relationships with fatigue and sleep quality?

van Markus-Doornbosch F, et al. Eur J Paediatr Neurol. 2018 Nov 14

Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile.

Chen LA, et al. J Pediatr Gastroenterol Nutr. 2018 Dec 11.

Comparison of Antibiotic Prescribing for Pediatric Community-Acquired Pneumonia in Children’s and Non-Children’s Hospitals.

Tribble AC, et al. JAMA Pediatr. 2018 Dec 10

Severe Respiratory Syncytial Virus Infection in Hospitalized Children Less Than 3 Years of Age in a Temperate and Tropical Climate.

Butler J, et al. Pediatr Infect Dis J. 2019 Jan;38(1):6-11.

Safety of Lactobacillus reuteri DSM 17938 in Healthy Children 2 to 5 Years of Age.

Kosek MN, et al. Pediatr Infect Dis J. 2018 Dec 10.

Antibiotics for urethral catheterization in children undergoing cystography: retrospective evaluation of a single-center cohort of pediatric non-toilet-trained patients.

Marzuillo P, et al. Eur J Pediatr. 2018 Dec 1.

Yield of brain imaging among neurologically normal children with headache on wakening or headache waking the patient from sleep.

Ahmed MAS, et al. Eur J Paediatr Neurol. 2018 Sep;22(5):797-802.

Paediatricians’ attitudes to and management of functional seizures in children.

Nielsen ES, et al. Eur J Paediatr Neurol. 2018 Sep;22(5):774-781.

Ultrasound-guided lumbar puncture in pediatric patients: technical success and safety.

Pierce DB, et al. Pediatr Radiol. 2018 Jun;48(6):875-881.

Does vitamin E prevent asthma or wheeze in children: A systematic review and meta-analysis.

Wu H, et al. Paediatr Respir Rev. 2018 Jun;27:60-68.

Evaluation of the Clinical Utility of a Real-time PCR Assay for the Diagnosis of Streptococcus pneumoniae Bacteremia in Children: A Retrospective Diagnostic Accuracy Study.

Murphy J, et al. Pediatr Infect Dis J. 2018 Feb;37(2):153-156.

Urinary Tract Infection in Children With Nephrotic Syndrome.

Narain U, et al. Pediatr Infect Dis J. 2018 Feb;37(2):144-146.

Safety of Outpatient Parenteral Antimicrobial Therapy in Children.

Fernandes P, et al. Pediatr Infect Dis J. 2018 Feb;37(2):157-163.

Epidemiology of Sepsis-like Illness in Young Infants: Major Role of Enterovirus and Human Parechovirus.

de Jong EP, et al. Pediatr Infect Dis J. 2018 Feb;37(2):113-118.

3. Guidelines and best evidence

Clinical Practice Guideline: Maintenance Intravenous Fluids in Children.

Feld LG, et al. Pediatrics. 2018 Nov 26.

Management of severe bronchiolitis: impact of NICE guidelines.

Griffiths B, et al. Arch Dis Child. 2018 Nov 24.

Which vasoactive drug should be first choice in paediatric septic shock?

McVea S, et al. Arch Dis Child. 2018 Nov 9.

Effective Discipline to Raise Healthy Children.

Sege RD, et al. Pediatrics. 2018 Nov 5.

Clinical Practice Guideline for the Management of Infantile Hemangiomas.

Krowchuk DP, et al. Pediatrics. 2018 Dec 24

Initial Oxygen Use for Preterm Newborn Resuscitation: A Systematic Review With Meta-analysis.

Welsford M, et al. Pediatrics. 2018 Dec 21

Room Air for Initiating Term Newborn Resuscitation: A Systematic Review With Meta-analysis.

Welsford M, et al. Pediatrics. 2018 Dec 21

Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER).

Hoofien A, et al. J Pediatr Gastroenterol Nutr. 2018 Dec 11.

Question 3: Can we diagnose asthma in children under the age of 5 years?

Yang CL, et al. Paediatr Respir Rev. 2018 Oct 24.

Why should we screen for arterial hypertension in children and adolescents?

Litwin M. Pediatr Nephrol. 2018 Jan;33(1):83-92.

Screening children for hypertension: the case against.

Ide N, et al. Pediatr Nephrol. 2018 Jan;33(1):93-100.

To screen or not to screen: for high blood pressure.

Tullus K. Pediatr Nephrol. 2018 Jan;33(1):81-82.

Interventions to Improve Medication Adherence: A Review.

Kini V, et al. JAMA. 2018 Dec 18;320(23):2461-2473.

4. Case reports

Rare and striking complication of Henoch-Schönlein purpura.

Moussaoui D, et al. Arch Dis Child. 2018 Nov 23.

Young girl with bruising: Finding the X factor.

Chan DW, et al. J Paediatr Child Health. 2018 Nov 13.

Case 19-2018: A 15-Year-Old Girl with Acute Kidney Injury.

Grisaru S, et al. N Engl J Med. 2018 Nov 1;379(18):e34.

Dissociative state: Returned traveller with a high fever and low heart rate.

Freeth P, et al. J Paediatr Child Health. 2018 Dec;54(12):1395-1396.

Acute Knee Swelling and Limp in a 10-year-old Child.

Islam S, et al. Pediatr Infect Dis J. 2018 Feb;37(2):194-195.

 

If we have missed out on something useful or you think other articles are absolutely worth sharing, please add them in the comments!

Please join us for our next #DFTB_JC on twitter…The DFTB/ADC Journal Club is a monthly collaboration between @DFTBubbles and @ADC_BMJ featuring a FREE access article from the latest issues of Archives of Disease of Childhood. January’s pick  is ‘ Can we use POCUS to Diagnose Pneumonia?’ Read the article here: bit.ly/2TMDf2M The chat will happen on twitter at Tue 22/1/19 at UTC2000hrs (That’s Wednesday 0700 23/1 AEST), just search the hashtag #DFTB_JC

The 25th Bubble Wrap [Holiday Edition]

Cite this article as:
Leo, G. The 25th Bubble Wrap [Holiday Edition], Don't Forget the Bubbles, 2018. Available at:
https://dontforgetthebubbles.com/the-25th-bubble-wrap/

With millions upon millions of journal articles being published every year it is impossible to keep up.  Every month we ask some of our friends from PERUKI (Paediatric Emergency Research in UK and Ireland) to point out something that has caught their eye.

The 24th Bubble Wrap

Cite this article as:
Leo, G. The 24th Bubble Wrap, Don't Forget the Bubbles, 2018. Available at:
https://dontforgetthebubbles.com/24th-bubble-wrap/

With millions upon millions of journal articles being published every year it is impossible to keep up.  Every month we ask some of our friends from PERUKI (Paediatric Emergency Research in UK and Ireland) to point out something that has caught their eye.

Securing funding for your research

Cite this article as:
Siobhán McCoy. Securing funding for your research, Don't Forget the Bubbles, 2018. Available at:
https://doi.org/10.31440/DFTB.16834

Money, makes the world go round and the research world is no different. Funding is a key element which can potentially stand in the way of making our research proposal a reality. My experience, along with anecdotal evidence from colleagues would suggest that, the quest for funding remains the toughest part to getting you research project off the ground.  In my career I have, however, been very lucky to meet a number of great clinical researchers and in doing this I have gleaned some tips and tricks from the best in the business.

In the following section I have outlined a few tips which will hopefully help you in securing that elusive grant.

This is the third part in a series on research. The previous articles are: choosing your research topic; and conducting your literature review.

  1. Take your time

These things have an awful habit of taking longer than you think they will, so be prepared and give it time. No matter how simple it seems in your head there are lot of different elements to pull together and some will be more time-consuming than others when it comes to proposals and grant writing.

 

  1. Choose your funder and scheme carefully

It can’t hurt to speak to the funders – they are there to help. Remember if you don’t ask the question, how will you know the answer? Asking questions allows you to gain insight into what the funder is interested in. Sign up for information feeds, find out what kind of research is in a funder’s remit and read through guidance and eligibility criteria carefully. This will reduce the chance of you applying for an inappropriate scheme/grant/funding source, which is a waste of your time and theirs.

 

  1. Source advice from people in the know

Chat to people in the know. Collaboration is king when it comes to grants and funding, therefore it is important to create a collaborative network within your department, hospital or speciality. Speak with your grants office, mentors and colleagues who have served on funding panels. Getting involved in grant writing at an early stage is a good idea, if only as an observer. Finding out how senior colleagues collate ideas, assemble teams and develop an application will be valuable to you going forward.

 

  1. Have a plan A, B & C

Plan your application and take your time, don’t rush it. Go out and look for inspiration to help pull together an idea that’s worthy of being funded. The wider the range of ideas you can expose yourself to, the more interesting concepts you’ll come up with.

 

  1. Building a good team

Creating the right team involves politics and a full reality check. The people involved in the proposal/application are just as important as the project you’re proposing. You need to make sure the skill mix is right. Identifying your strengths and weakness before you get started will allow you to single out a person/people who will add value to the team. You may have a strong background in methodology and study design but be useless at statistics, therefore you will need someone in your team with an aptitude for statistics.

Additionally, it is always helpful to have a senior colleague involved, potentially someone who has a good track record with funding/grants. By association these people add gravitas and can provide comfort to a funding body that you are someone who can be considered/trusted with a significant grant. The funding bodies will want to see that you have considered all aspects of the project process from inception to delivery, therefore, you must provide evidence that the team is capable of delivering what you propose and in turn validating the investment.

 

  1. You must propose solid objectives

Funders like to see that you have considered all the options. For you to be in with any chance of getting through an application board they need to see concise, specific aims and well-defined criteria to quantify success. It is important that you portray to the application board what it is that each experiment will deliver and how that aligns with your aims? Vagueness is your enemy here.

 

  1. Hypothesis – make it crystal clear

When it comes to your hypothesis, there is no place for ambiguity. Funders and your team need to see a clear and specific rationale for your work. They need to know what you are doing and why. You must convince the funder that the gap in the knowledge you have identified is relevant and that your study can fill or work towards filling it in your own unique way. It is ok to have an ambitious project, however, you must be able to explain why and convince funders that you have a fair chance of achieving your goal.

 

  1. Impact

The main question that is asked of every researcher in relation to their work/proposal is…so what? You need to be able to get your audience to see why your work will contribute to improving human health. You need to clearly and concisely explain the intended consequences of your work. Funders need to know who will benefit in the short, medium and long term. What are you going to do to increase the chances of your work reaching those people? Even if your proposal isn’t earth shattering you must be able to explain the pathway that links your work to improving human health.

 

  1. Baseline data

The panel need to see that you have invested in your proposal – if you can provide preliminary data validating your proposal it will reassure the panel that you are a good risk. The results of this preliminary work will also help to support the proposal and indicate to the panel there is more work to be done and their investment is valid.

 

  1. Tell a compelling story

This is your sales pitch. Identify the hook, a key feature/s that your proposal hangs on. The panel need a convincing, focused narrative – you have to imagine you’re selling an idea to an audience. Make sure that this narrative links each experiment to your main aims.

 

  1. The Maths part

Your Statistical Analysis Plan (SAP) is essential as the panel need to see you have considered your data analysis from the outset. You should always engage your statistician from the beginning of the study design process. They help you establish your data collection methods, justify your sample size and identify appropriate statistical tests. It is important to get your sums right, lack of conviction in this section makes the funding panel uneasy. Use the right tools in the right way.

 

  1. Get a second pair of eyes

Get a second opinion from a mentor or a senior colleague. Proof read, spell check and stick to specified formats – remember the little details count. Presentation, punctuation, sentence syntax and grammar set the tone for how people feel about your work – they do matter. Remember only provide the information the application specifies.

For example: if the applications ask for a publications list (max 10 publications), only provide 10 of the most recent/relevant publications. If you don’t it shows lack of attention to detail.

 

Topics for clinical research for the most part are driven by what we as clinicians encounter in our daily working lives. Passion is no doubt an essential element in what drives us forward in clinical research and helps us to keep going when we hit a bump in the road. Despite our passion and drive we cannot produce robust, ethical and clinically significant research with this alone.