Cite this article as: Marc Anders. Tetralogy of Fallot, Don't Forget the Bubbles, 2013. Available at: https://doi.org/10.31440/DFTB.3485Definition: TOF is the most common cyanotic congenital heart disease. It accounts for 5% to 10% of all congenital heart disease, and has an incidence of approximately 1:2000 live births.