Anaphylaxis Module

Cite this article as:
Kat Priddis. Anaphylaxis Module, Don't Forget the Bubbles, 2020. Available at:
https://doi.org/10.31440/DFTB.27221
TopicAnaphylaxis
AuthorKat Priddis
DurationUp to 2 hours
Equipment requiredAdrenaline auto-injector if planning a demonstration on a model
  • Basics (10 mins)
  • Main session: (2 x 15 minute) case discussions covering the key points and evidence
  • Advanced session: (2 x 20 minutes) case discussions covering grey areas, diagnostic dilemmas; advanced management and escalation
  • Sim scenario (30-60 mins)
  • Quiz (10 mins)
  • Infographic sharing (5 mins): 5 take home learning points

We also recommend printing/sharing a copy of your local guideline.

Anaphylaxis is a severe, life-threatening, generalised or systemic hypersensitivity reaction.

Anaphylaxis is described as

  • Sudden onset and rapid progression of symptoms 
  • Life-threatening Airway and/or Breathing and/or Circulation problems 

*Skin and/or mucosal changes (flushing, urticarial, angioedema) are absent 20% of cases*

Angioedema is similar to urticaria but involves swelling of deeper tissues, most commonly in the eyelids and lips, and sometimes in the mouth and throat.

There can also be gastrointestinal symptoms (e.g. vomiting, abdominal pain, incontinence).

Fatality <1%, increased in those with pre-existing asthma. Approximately 20 anaphylaxis-related deaths in the UK every year. 

From a case-series (resus council), fatal food reactions cause respiratory arrest typically after 30–35 minutes; insect stings cause collapse from shock after 10–15 minutes; and deaths caused by intravenous medication occur most commonly within five minutes. Death never occurred more than six hours after contact with the trigger. 

Pathophysiology

What is an allergy?

It is the body’s response to an external ‘allergen’. An unnecessary immune response to an innocuous substance. 

Common allergens/triggers include: • Food: nuts, milk, fish • Venom: wasp, bee • Drugs: antibiotics, anaesthetic drugs • Contrast media • Latex

Reactions are either delayed type IV or immediate type I. IgE-mediated allergy is broadly characterised as a Type 1 hypersensitivity. Other hypersensitivity reactions (II, III and IV) are mediated by other antibody classes, immune cells or cellular components. Non-IgE mediated reactions typically cause symptoms to appear more slowly, sometimes several hours after exposure. 

Allergy is increasing in prevalence. Theories for this include the ‘Hygiene Hypothesis’, the idea that increased exposure to microorganisms correlates with a decreased tendency to develop allergy and more recently the ‘Old Friends Mechanism’ which links the tendency to develop allergy to an individual’s microbiome (collection of microorganisms living in and on an person’s body). 

Interestingly, kids in developing countries have a decreased allergy prevalence, thought to be because of less sanitation, more exposure to microbes and increased time spent outdoors. 

How do we develop allergic reactions? 

Part 1: Sensitisation

An allergen enters the body and is captured by an antigen presenting cell, that scoops it up and nicely presents it immune cells, particularly T cells (in a similar manner as if the allergen was a foreign invading microbe). Through a number of immune interactions between T cells and B cells, B cells produce allergen-specific IgE antibodies. These get released into the blood, where they bind to mast cells (the major allergy immune cell) as well as other friends like basophils. In some individuals, this can cause a ‘sensitisation’ i.e. the next time their body meets that particular allergen it’s going to go on the offensive. 

Part 2: Re-exposure

Our patient is now carrying allergen-specific IgE bound mast cells. Upon re-exposure, the offensive allergen binds to IgE, causing the mast cells to initiate an aggressive and immediate immune response. 

Mast cells on the attack: 

Mast cells are granular cells, containing many secretory granules that all get released on activation. The binding of IgE causes rapid degranulation, and a shower of inflammatory compounds, including histamine. Result? Local inflammations, and allergy symptoms (see presentation of the patient in anaphylaxis below). 

An 8 year old girl presents after collapsing following attendance at a friend’s birthday party. She was noted to have been eating a sandwich, then promptly developed respiratory distress. On admission with the ambulance crew she is audibly wheezy, with swelling of the tongue and lips.

How would you assess this child?

What is your immediate management?

How much adrenaline do you give and how? Any adjunct therapies to consider?

Usually the parents or child will give a history of exposure to an allergen. This is useful however not essential. If the clinical picture is of anaphylaxis – treat first and seek the provoking agent second!

Life-threatening features of anaphylaxis include:

  • Airway: swelling, hoarse voice, stridor 
  • Breathing: shortness of breath, tachypnoea, wheeze, cyanosis, respiratory arrest 
  • Circulation: pale, clammy, tachycardia, low blood pressure, shock, cardiac arrest
  • Confusion, agitation or decreased level of consciousness can occur due to above problems
  • Remember the ABCDE approach
  • Get senior help 
  • Remove the allergen if possible – remove a stinger, stop IV drugs, but don’t make a patient vomit if suspected food allergy – risk of aspiration. 
  • Maintain oxygen delivery 15l via non-rebreather mask
  • Get monitoring on – and get a BP early
  • If hypotensive then get IV access and bolus 20mls/kg 0.9% sodium chloride

Delayed administration is directly linked with increased morbidity and mortality 

  • Scientific evidence is weak, instead based on what is considered safe and practical. 
  • Adrenaline IM – use 1 in 1000 (or 0.1% – 1mg/ml)
  • The dose is 0.01ml/kg or 0.01mg/kg. Max dose is 0.5ml. 
AgeDose
< 6 years old
150 micrograms IM (0.15 mL)
6 – 11 years old300 micrograms IM (0.3 mL)
>12 years old500 micrograms IM (0.5 mL)
  • Give as an IM injection into the anterolateral thigh. IM provides faster rise in plasma and tissue concentrations than sub-cutaneous route. 
  • Don’t give IV boluses unless there is cardiac arrest. 
  • Can use the patient’s own adrenaline auto-injector if not already used

Alpha receptor agonist 

  • Reverses peripheral vasodilation
  • Reduces oedema

Beta receptor agonist

  • Bronchodilation
  • Increased force of myocardiacl contraction
  • Suppresses histamine and leukotriene release
  • Inhibits mast cells – attenuates severity of IgE-mediated allergic reactions. 

Normally only occur with IV administration (at which point PICU will be present)

  • Arrythmias
  • Hypertension
  • Pulmonary haemorrhage
  • Intracranial haemorrhage
  • Rapid onset – should see improvement in 5 minutes
  • Duration of action is 15 minutes – beware of rebound
  • Absolutely – 20% of patients require more than one dose! 
  • By the third dose please call PICU
  • Is the child wheezing? Consider a salbutamol neb 2.5mg/5mg depending on age
  • Antihistamines (H1 and H2 blockers) are a second line treatment and should not delay adrenaline administration! Examples such as chlorpheniramine are useful for urticaria, nasal and ocular symptoms
  • Steroids – think about steroids. 1mg/kg prenisolone (PO) or 4mg/kg hydrocortisone (IV) – but remember slow onset of action. 
  • Keep patient comfortable and minimise distress
  • Ideally have them lying down to aid venous return (hypotension can precipitate cardiac arrest)
  • NICE evidence: Limited evidence from systematic review – consider mast cell tryptase investigations only if reaction is thought to be drug, venom or idiopathic related! Send three timed samples. Immediately after reaction has been treated. 1-2 hours after the start of symptoms. At 24 hours or in convalescence (baseline sample) after the reaction.

A 3 year old presented with a localised erythematous rash after being stung by a bee at a family picnic. His family attended PED where he subsequently developed respiratory distress and he was treated with IM adrenaline. After a couple of hours he was playful and appeared well and his parents want to take him home.

What would you say to the parents?

How would you manage this patient?

What key points make up the discharge planning? 

  • Occur in 6–11% of children.
  • Usually manifest in the first 8 hours after exposure, but may be delayed up to 72 hours.
  • NICE evidence: children who have had emergency treatment for suspected anaphylaxis should be admitted to hospital under the care of a paediatric medical team. No direct evidence from systematic review however in light of risk of biphasic reaction risk, better to keep them in overnight for observation. 
  • All children with suspected anaphylaxis will require risk planning and allergy avoidance advice
  • Corticosteroids have been advocated to prevent protracted and biphasic reactions (no RCT on this). Recent systematic review and meta-analysis (Lee et al) included 27 studies with 4114 anaphylaxis cases, of whom 192 (4.7%) had biphasic reactions. 
  • Steroid administration did not affect the likelihood of a late phase reaction (OR 1.52, 95% CI 0.96 to 2.43). In fact, there was a non-significant trend towards increased risk, (?because steroid use was more common with severe reactions). 
  • Biphasic reactions were more common where hypotension was present at initial reaction (OR 2.18, 95% CI 1.14 to 4.15), but this is unusual in food-induced anaphylaxis. 
  • The median time to onset of biphasic symptoms was 11 (range 0.2–72) hours, that is, 50% of reactions occurred >11 hours after initial reaction. Hence why all children should be admitted. 
  • Children and young people at risk of anaphylaxis should be referred to clinics with specialist competence in paediatric allergies. 
  • Children and young people who are at high risk of an anaphylactic reaction should carry an adrenaline auto-injector and receive training and support in its use.
  • They will need 2 auto-injectors – 20% require a second dose
  • Medic-alert bracelet and patient education
  • Further follow up – the most common way to diagnose an IgE-mediated allergy is through a blood test to identify allergen specific IgE or a skin prick test which results in a local inflammatory reaction after administration of the trigger allergen.
  • Oral food challenges – need to have appropriate resus facilities. 
  • AIT – Allergy immunotherapy or ‘Desensitisation’ works by changing the immune system’s response. These changes may include producing less IgE, producing ‘blocking’ IgG antibodies, and producing more regulatory T cells, promoting tolerance and a less active immune response. However, the exact mechanism behind desensitisation is not yet known and it is likely that different patients exhibit different immune profiles following the treatment. Only available for wasps, bees, dust mites and animal dander. Clinical trials for food allergies are on-going.

Can you administer IM adrenaline? (8 minutes)

A 6 year old patient with spina bifida is currently admitted with an LRTI. She has been having a course of amoxicillin for the last week. You are crash bleeped to the ward where she is having her urinary catheter changed by a bank nurse. She is pale and cool to touch, with increased respiratory rate.

What’s going on? Is this allergy? Is this anaphylaxis?

How would you treat it?

What allergy avoidance advice do you give?

  • Initial management: Observations and assess (BP)
  • Initial presentation of anaphylaxis – high safety margin for IM adrenaline
  • Hypotension as a warning sign (absence of a rash) – is it fluid responsive? May require large volumes of fluids. No evidence for crystalline vs colloid. Give 0.9% saline or Hartmanns. 
  • Explore medical history for triggers, explore unusual or uncommon triggers (e.g. exercise as a trigger, consider co-existing triggers e.g. prawns and exercise)

The following are risk factors for latex allergy:

  • Repeated bladder catheterisation 
  • Neural tube defects: Spina bifida 
  • Cloacal abnormalities 
  • Multiple surgical procedures, especially as a neonate 
  • Atopy and multiple allergies 
  • Food allergies: fruit and vegetables including bananas, celery, fig, chestnuts, avocados, papaya and passion fruit are most significant. 
  • Children with a strong or confirmed allergy to banana should be considered allergic to latex and managed accordingly.

The most common food trigger for fatal anaphylaxis in children in the UK is milk, followed by peanut and tree nuts.  While there is broad public recognition of the risks posed by nuts, cow’s milk allergy is often perceived as being less severe. However, milk allergy persisting into school age is often associated with other coexisting atopies (such as asthma) and more severe reactions, particularly in the 30%–40% of milk-allergic children who are unable to tolerate milk in well-baked foods (such as biscuits or cakes). Such exposure often results in delayed reactions which mimic asthma; under such circumstances, it may not be obvious that the child has been exposed to milk. Therefore, always consider anaphylaxis in someone with a known food allergy who has sudden breathing difficulty.

An 8 year old girl presents after collapsing following attendance at a friend’s birthday party. She was noted to have been eating a sandwich, then promptly developed respiratory distress. She has had two epipens with the ambulance crew, and a further dose in PED. You are called as senior support. Her sats are dropping and she is becoming bradycardic.

If the patient isn’t improving after IM adrenaline, what are your next management plans?

How do you prepare for intubation?

What do you do next?

  • Ensure the most senior people are present
  • Contact retrieval services early
  • How would you determine this? 
    • Airway obstruction/cardiovascular collapse
  • Who should be involved in the conversation? Who should perform the intubation?
    • Most senior anaesthetist, ideally with ENT support 
  • What do you do whilst prepping
    • Continue adrenaline – IM and nebulised whilst prepping for intubation
  • What sedation would you use?
    • Choose cardiovascular stable drugs – a drop in BP at this stage can precipitate cardiac arrest. Consider ketamine, fentanyl and rocuronium in 1:1:1 ratios. 
  • What equipment would you use?
    • Have advance and difficult airway trolley prepped and ready
  • What settings would you use?
    • Ventilate as for air trapping/bronchospasm
    • Pressure control (aim PIP <35 cm H2O)
    • Slow respiratory rate (e.g. 10-15 bpm)
    • Long expiratory time (e.g. I:E 1:2)
    • Permissive hypercapnia (aim pH >7.2)
    • PEEP 5 – 10 cm H2O to overcome intrinsic PEEP
    • Consider manual decompression
    • Muscle relax
  • Regular chest physiotherapy and suction for mucus plugging
  • Treat bronchospasm as per asthma guidelines (CATS or local)
  • Watch for pneumothoraces
  • Consider IV adrenaline infusion
  • Consider NaHCO3 for profound/refractory acidosis
  • Might need to escalate to IV adrenaline infusion – prescription calculation available on CATS website – ‘in a hurry’ drug chart (see appendix)
  • UK Resus council: No evidence to base a dose recommendation – the dose is titrated to response. Can titrate in presence of continued haemodynamic monitoring. Consider arterial line to enable continuous monitoring. 
  • A child may respond to a dose as small as 1microgram/kg. This requires very careful dilution and checking to prevent drug errors.

All adverse drug reactions should be reported to the Medicine and Healthcare products Regulatory Agency (MHRA) using the “Yellow Card” scheme (found in BNF and MIMS). 

The patient must be referred to an allergist in a defined Regional Allergy Centre. 

All fatal cases of suspected anaphylaxis should be discussed with the coroner.

What dose of adrenaline would you give to a 5 year old presenting in suspected anaphylactic shock?

A: 150 micrograms IM (0.15 mL) of 1:1000

B: 150 micrograms IM (0.15 mL) of 1:10000

C: 300 micrograms IV (0.15 mL) of 1:1000

D: 300 micrograms IM (0.15 mL) of 1:10000

The correct answer is A.

IM is always preferred in children owing to its broad safety profile. 1:1000 is the correct concentration. 1ml/kg of 1:10000 IV is the cardiac arrest dose. If the child does arrest then stop using IM and move to the standard APLS arrest dose as per protocol.

In order to diagnose anaphylaxis there must be a rash

A: True

B: False

The correct answer is false.

Cutaneous symptoms (most commonly urticaria or ‘hives’) are absent in around 10-20% of anaphylaxis reactions and where present may be delayed in onset. This is consistent with a case series of six paediatric fatalities due to food anaphylaxis, where only one child had evidence of skin involvement: the lack of skin signs may have delayed diagnosis and appropriate treatment with epinephrine, contributing to the fatal outcome.

The Australasian Society of Clinical Immunology and Allergy (ASCIA) recently issued new guidelines, which define anaphylaxis as:

  • Any acute onset illness with typical skin features (urticarial rash or erythema/flushing, and/or angio-oedema), PLUS involvement of respiratory and/or cardiovascular and/or persistent severe gastrointestinal symptoms; or
  • Any acute onset of hypotension or bronchospasm or upper airway obstruction where anaphylaxis is considered possible, even if typical skin features are not present.

These criteria better reflect increasing recognition that cutaneous manifestations are often absent or appear late in near-fatal and fatal anaphylaxis.

Antihistamines can be used to treat anaphylaxis initially; epinephrine is only needed if symptoms worsen

A: True

B: False

The correct answer is false.

Histamine is only one of many inflammatory mediators released during anaphylaxis. Oral antihistamines take around 30 min for onset of effect; intravenous chlorphenamine has a faster onset, but can cause hypotension. 

Antihistamines are not effective against anaphylaxis: their prophylactic use during controlled immunotherapy does not prevent anaphylaxis, and any apparent response during acute management of reactions is most likely due to the patient’s own endogenous epinephrine. Antihistamines have now been relegated to third-line therapy in international guidelines; their use is limited to the relief of cutaneous symptoms and should never delay the administration of epinephrine or fluid resuscitation during patient stabilisation.



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Idiopathic anaphylaxis

Cite this article as:
Abbey Ward. Idiopathic anaphylaxis, Don't Forget the Bubbles, 2020. Available at:
https://doi.org/10.31440/DFTB.21876

A fifteen year old boy came into ED, brought in by his parents after having to use his EpiPen at home. He was at school, he was well in the morning. Suddenly while walking between classes he started to feel nauseous, sort of breath and tight chested. Once again he was having an anaphylactic reaction, but he did not know what he was reacting to.

 

Anaphylaxis

Anaphylaxis is a common severe allergic reaction to an allergen. IgE binds to the allergen which causes degranulation of mast cells and basophils leading to histamine release.  This in turn causes smooth muscle constriction and bronchoconstriction as well as angioedema. This is a type 1 immunological reaction.

This reaction leads to facial swelling, bronchoconstriction, airway obstruction, rash, vomiting, diarrhoea and fluid redistribution leading to shock and respiratory failure. Anaphylaxis is a life-threatening medical emergency and needs prompt treatment as well as education to prevent further anaphylactic attacks. So the prevention of anaphylactic shocks is highly important, and usually this can be done by tracing common allergens that the patient was exposed to right before they develop a reaction. However, in some cases this is more difficult to determine and may not be obvious.

In our case there was no identifiable allergen at all.

 

Idiopathic anaphylaxis

Idiopathic anaphylaxis is a condition where patients develops an anaphylactic reaction without a causative agent. The patient develops an anaphylactic reaction without any form of trigger. This can be dangerous, as patients can spontaneously develop anaphylaxis without any warning, putting them in life threatening situations regularly and without warning. It is unclear what causes this and although patients are commonly very atopic and will have other atopic conditions and allergies.

 

Treatment

Treatment for idiopathic anaphylaxis is the same as for any other cause of anaphylaxis in the acute setting. Patients need treatment with adrenaline and steroids. However, in the long term they need to be well educated and prepared, including education on what anaphylaxis is and how important it is, using EpiPen’s and how important it is to always carry one in case of a reaction developing.

The child in out case, underwent multiple allergen and immunological investigations and although multiple allergens were identified, he continued to have anaphylactic reactions without apparent triggers.

 

Key learning points

  • Anaphylaxis can occasionally be idiopathic although this is rare
  • Idiopathic anaphylaxis has the same pathology and presentation to allergen mediated anaphylaxis
  • Patients with idiopathic anaphylaxis need the same acute treatment
  • Long term treatment involves a lot of education around the condition

Practice made perfect?

Cite this article as:
Sonia Twigg. Practice made perfect?, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.20694

Okay, perhaps  not perfect but we think these bite sized chunks of simulation from Children’s Health Queensland are pretty good! They are free to download and play with. You can find access to all current OPTIMUS resources here. Enjoy!

 

Introducing BONUS – A Bank of Independently Useful Sims

 

 

 

What are they?

OPTIMUS BONUS is an ongoing project driven by Children’s Health Queensland involving the creation of simulation education packages on topics in paediatric resuscitation.  Each package contains;

  • An introduction by an expert explaining why the topic is important.
  • A simulation with clear learning objectives, instructions and hints for debriefing.
  • Pre-reading resources for participants. These are fun and easy to read resources including podcasts, videos, guidelines and apps.
  • An infographic summarising the topic. QR codes on the posters link to Just In Time Training resources including videos and guidelines.  Just point the camera on your smart phone at the poster and a link will appear to the website to see the video.

 

Who writes them?

The STORK team (Simulation Training Optimising Resuscitation in Kids) from Children’s Health Queensland provides simulation based education throughout Queensland.  We provide two courses as part of our OPTIMUS curriculum; Optimus CORE (for first responders) and Optimus PRIME (for mid phase care while awaiting retrieval).

 

 Why did we make them?

 

What we love about them

  • They’re free to download, expert reviewed, repeatedly tested and assessed by a statewide advisory group to ensure we’re providing a quality product.
  • Our infographics look awesome, summarise the key messages, are easy to share on social media and easy to store on your phone.
  • Some packages contain Just in Time Training JITT resources and videos via QR codes to give you the info you need when you need it :
    • Just scan the QR codes on your phone to see refresher videos before you go and perform that skill
  • We’ve curated great open access #FOAMed resources on paediatric topics for each Simulation, so you can deep dive into more learning before or after the Sim!

 

Love the simulations and want to help out?

Thanks!  We need your help to share these simulations and infographics online any way you can. Shout out to @childhealthqld @LankyTwig @Caroelearning @paedsem and @symon_ben on twitter if you’re using them!

The other thing that REALLY helps is getting good feedback.  So, if you have thoughts on them to share fill out the surveys via the QR codes in the package so we can keep making better simulations to share with the world.

If you’d like to know more, email us at stork@health.qld.gov.au

Other than that, retweet them, share them widely, and help us improve paediatric care everywhere in the world.

 

Enjoy!

Sonia and the BONUS team

Dr Sonia Twigg (@LankyTwig), Dr Benjamin Symon (@symon_ben), Dr Carolina Ardino Sarmiento (@caroelearning), Dr Ben Lawton (@paedsem) Ms Louise Dodson and Mrs Tricia Pilotto.

 

Selected references

Case, Nicky, “How to remember anything forever-ish.:  Oct 2018.  Available at: https://ncase.me/remember/

Cheng et al, “Resuscitation Education Science: Educational Strategies to Improve Outcomes from Cardiac Arrest; A Scientific Statement from the American Heart Association.”Circulation 2018; 138: e82-e122. Available at: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000583

Cheng et al, “Highlights from the 2018 AHA Statement on Resuscitation.” June 2018.  Available at: https://canadiem.org/aha-scientific-statement-on-resuscitation-education/

Dubner S.“Freakonomics Radio.  How to become great at just about anything (Ep 244).” Apr 2016.  Available at: https://freakonomics.com/podcast/peak/

Ericsson A,“Peak” Vintage 2017.

All about Allergies: Domenic Cincotta at DFTB18

Cite this article as:
Team DFTB. All about Allergies: Domenic Cincotta at DFTB18, Don't Forget the Bubbles, 2019. Available at:
https://doi.org/10.31440/DFTB.20481

Children have become global gastronomic explorers and are constantly trying unusual foods. It is not these that are generally of concern to the healthcare provider but regular, everyday foods that are found in nearly every larder or store cupboard.

PAC Conference 2015 – Cincotta on allergy in ED

Cite this article as:
Davis, T. PAC Conference 2015 – Cincotta on allergy in ED, Don't Forget the Bubbles, 2016. Available at:
https://dontforgetthebubbles.com/pac-conference-2015-cincotta-on-allergy-in-ed/

We have teamed up with APLS to share the videos from their Paediatric Acute Care Conferences. These videos have never been open access before, so if you weren’t able to attend the conferences, then now’s your chance to catch up.

The PAC Conference is run each year by APLS and consists of presentations on a range of topics relevant to paediatric acute and critical care.