Intubation

Cite this article as:
Anders, M. Intubation, Don't Forget the Bubbles, 2013. Available at:
http://doi.org/10.31440/DFTB.3880

Indication: to secure the airway: severe airway obstruction/inadequate protective reflexes (coma or prolonged seizures) to facilitate ventilation: hypoxaemic and/or hypercarbic respiratory failure Intubation should NOT be attempted by the inexperienced if more skilled personnel are available. Two doctors always present if possible! Assessment: how urgent is the intubation? anatomical abnormality, which would suggest difficult intubation?…

Inotropes and vasopressors

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Anders, M. Inotropes and vasopressors, Don't Forget the Bubbles, 2013. Available at:
http://doi.org/10.31440/DFTB.3876

Definition: Inotropes: sympathomimetic agent which act on the sympathetic (or adrenergic) nervous system (β-receptors) resulting in positive inotropic (increase in contractility), chronotropic (increase in heart rate), dromotropic (increase in conduction of impulse) and lusitropic effect (improved diastolic relaxation) Vasopressors: sympathomimetic agent which act on the sympathetic (or noradrenergic) nervous system (α-receptors) resulting in vasoconstrictor effect The ideal…

Analgesia and sedation

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Anders, M. Analgesia and sedation, Don't Forget the Bubbles, 2013. Available at:
http://doi.org/10.31440/DFTB.3867

Intravenous anaesthetic agents (see table): classified as barbiturates (thiopentone) and non-barbiturates (propofol and ketamine) thiopentone use is largely limited to induction in status epilepticus and for treatment of raised ICP; it has no analgesic properties and is in fact anti-analgesic at sedative doses propofol is suitable for induction (bolus) and maintenance of sedation/anaesthesia (infusion); it…

Basic pharmacology

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Anders, M. Basic pharmacology, Don't Forget the Bubbles, 2013. Available at:
http://doi.org/10.31440/DFTB.3866

Routes of administration and systemic absorption of drugs: Rate of systemic absorption determines onset, intensity and duration of action. Drug solubility and blood flow to the site of absorption are the most important factors: Oral/enteral: most convenient & economic route of administration complicated by nausea/emesis & irregularities in absorption principle site of absorption is the…

Heart transplantation

Heart transplantation

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Cite this article as:
Anders, M. Heart transplantation, Don't Forget the Bubbles, 2013. Available at:
http://doi.org/10.31440/DFTB.3669

Indication: life expectancy <2 years and/or unacceptable quality of life, end stage CHD, DCM, HCM (see cardiomyopathy) Risk profile: PVR (low risk: PVR ≤4 WU or TPG ≤10 mmHg, medium risk: PVR 5-9 WU or TPG 10-20 mmHg) High risk/contraindicated: PVR >9 WU or TPG ≥15 mmHg. In high risk patients: trial with pulmonary vasodilator in cardiac…