Should we test RSV-positive infants for UTIs?

Cite this article as:
Tessa Davis. Should we test RSV-positive infants for UTIs?, Don't Forget the Bubbles, 2015. Available at:

RSV-positive bronchiolitis in infants is one of the most common reasons for admission to hospital. Sometimes they spike temperatures. It is widely recognised that the rate of serious bacterial infection in these infants is low. But what about the rate of UTIs? Should we be doing urine dips on all febrile babies with bronchiolitis, or is that overkill?

This study hypothesised that UTIs in 3-12 month old febrile, RSV-positive infants are rare.

Kaluarachchi D, Kaldas V, Erickson E, Nunez R, Mendez M., When to perform urine cultures in respiratory syncytial virus-positive febrile older infants? Pediatr Emerg Care. 2014 Sep;30(9):598-601. 

Who was studied?

This was a retrospective study of all infants (0-12 months) admitted to a US paediatric unit between 2006 and 2012.

Inclusion criteria were:

  • febrile infants
  • admitted as an inpatient
  • positive for rapid RSV antigen detection test or NPA

Exclusion criteria were:

  • born before 36 weeks
  • known urinary tract abnormalities
  • previous UTIs
  • known immunodeficiencies
  • already give antibiotics 72 hours prior to urine sample

All patients had urinalysis and urine culture obtained by catheterisation.

412 patients were included (57% boys, 43% girls).

What were the outcomes measured?

Patients were retrospectively examined for a positive urinalysis (leukocyte +/- nitrite or 5+ WCC on microscopy).

They were also assessed for presence of UTI (growth of a single identified pathogen).

Other measured outcomes were: age, sex, race, circumcision status, maximum temp, WCC, and neutrophil count.

What did the results show?

Out of 414 infants, 6.3% had a positive urine culture.

The most common pathogen was E. coli.

Sex, race, age, peak temp, WCC or neutrophil count were not associated with an increased risk of UTI.

In infants aged 3-6 months, 7.7% had a concurrent UTI.

Circumcised boys had a reduced risk of UTI.

RSV positive bronchiolitis is very common. When these infants become febrile, we should not be discounting a concurrent UTI. 6.3% of infants do have a UTI as well as their bronchiolitis. Don’t assume the temp is due to bronchiolitis – check the urine.


Twenty tips to take your Neonatal Resus to the next level – Part 2

Cite this article as:
Henry Goldstein. Twenty tips to take your Neonatal Resus to the next level – Part 2, Don't Forget the Bubbles, 2015. Available at:

Covering the Birthsuite can be wonderful and terrifying. Neonatal resus should be both easy and scary, every time. If you’re not even a little, tiny bit scared, you’re quite possibly “doing it wrong”, and almost always, sticking to the algorithm ensures that you do the right thing for the patient.

Twenty tips to take your Neonatal Resus to the next level – Part 1

Cite this article as:
Henry Goldstein. Twenty tips to take your Neonatal Resus to the next level – Part 1, Don't Forget the Bubbles, 2015. Available at:

Covering the birthsuite can be wonderful and terrifying. Neonatal resus should be both easy and scary, every time. If you’re not even a little, tiny bit scared, you’re quite possibly “doing it wrong”, and almost always, sticking to the algorithm ensures that you do the right thing for the patient.


This post shares a few of my own tips and idiosyncrasies in preparing for and undertaking neonatal resus, particularly in the regional setting where a tertiary NICU isn’t just a buzzer and short walk away. It’s by no means the full course; I strongly recommend you do a NeoResus course with simulation training before you’re anywhere near the Birthsuite. This post is more along the lines of tips, tricks & philosophies to augment the standard of care you’ll learn on the NNR program.

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1. Where’s your backup?

The big yellow stripe down the side of the Neonatal Resus algorithm is there for a good reason. If you’ve been called, the birth suite team has identified that you’re the first point of escalation. At a minimum, the consultant on call and your nursery number should be in the back of your head. It’s also good to write down the number on either the whiteboard in theatres, or somewhere you can point to, like the sheet of the resuscitaire at a point that’s unlikely to be obstructed or bloodied. Even better if there’s a neonatal code team with or without “emergency buzzers”, know where it is and what the number is.


2. Get familiar

I’ve become more fastidious about this after doing a few years at regional centres with variable assistance and support available. Resus is a ‘hard to control’ situation, and if you’re lucky enough to be given a ‘heads up’ then it makes sense to have things in a way that’s functional.

I cannot emphasize enough the importance of getting to know your resus trolleys before you need to do a resus. Early in your first shift or set of shifts, going to birth suite, introducing yourself to your new colleagues and having played with whichever trolley/resuscitaire/panda they have and understanding the gas supplies will do you a world of help when it comes to the crunch; and especially when transitioning to transport to your nursery.

Same goes for the layout of the birth suite and the staff. If you’re on a six-month or year-long posting, the chances are you’ll do a resus with almost every member of staff. Establish a good working relationship with your midwifery colleagues in times of low stress.

If you know you’re covering the birth suite – in addition to other roles – walk through there at the start of each shift. It makes sense to have an idea what might be coming up over the next 8-14+ hours, and probably allows you to plan the shift a bit more effectively.


3. Start the timer/clock when the baby is born

Time can melt away in a resus situation. Being time-aware is essential not only to trigger certain actions but for noting significant events during the resus. In most neo resus situations, the person leading will start the clock; however, the job can be delegated then rechecked by the senior within a few seconds.


4. Airway

Set your suction  at <120mmHg. Nelson suggests that pressures higher than this can be associated with oesophageal rupture. I use Size 8 FG suction catheters because size 10 (in most brands) has fenestrations which can drag on surfaces you’re not intending to suction. Size 12 tends to be a bit large for most neonatal nostrils.

Your backup is your lungs. One of my NICU consultants tells me this was the standard in the 70s and there are a few much more recent stories of a quick-thinking registrar saving the day after a suction failure at an inopportune moment; a heroic action, but with a real risk of exposing yourself to Hep.C et al in some patients.


5. Breathing

Aside from meconium deliveries, it’s rare to have a primary (large) airway problem. The ventilation devices you use most commonly rely on your ability to make a seal and do airway manoeuvres. This is also a good time to palpate +/- visualize the palate to ensure there’s not a cleft hiding away there. A lot of neonatal resus programs, in my opinion, over-emphasize the importance of intubation; in practice, it’s more important and much much more common to use the basics first.

Take note of the sizes of the masks; they range from 72mm down to 40mm, so you need one that’s the appropriate size. I’ll load up a 60mm at term and 50mm if the baby is <35/40 or <2kg, and stay aware of where the alternatives are kept.

In Australia, the T-piece is a commonly used airway. The brand Neopuff has been around for a while, so I’ll continue to use the term here. I set the pressures at 30/8 in a term neonate. Most neonatal resus programs will quote a PEEP of 5-8cm. I tend towards 8cm, after reading this study by Probyn et al, which suggests no increased risk of pneumothorax in 26-week equivalent lungs. It’s worth a read, here.

Some units, often those attached to a NICU, may use an anaesthetic bag (Mapleson C) as first-line. They need a gas source and a bit of practice to use but allow for a better ‘feel’ of the lungs for the experienced operator.

The next level of airway is:

  • Intubation & ventilation
  • ETT 3.5 @ term x2
  • Laryngoscopes w/ size 1, 0 (straight or curved, as per preference).
  • Attach your ETT to a capnograph and either the Neopuff or a bag-mask valve for transport to the NICU/SCN.
  • Under 1kg, the capnograph is unlikely to have sufficient CO2 output to change the colour, so think about all the other signs of a correctly placed ETT.

Always, ALWAYS find and check your backup, a self-inflating bag, 250mL. It’s also good for babies born in the car park or ward, so knowing where to grab one in a hurry can be quite useful. If, however, the baby is spontaneously ventilating, this option is off the table, as they’ll not have the exhalation strength to overpower the pressure valve, thus effectively asphyxiating the child. To be avoided.


6. Meconium

Say to the birth assistant; “There’s meconium, so do not stimulate the child.” If the child is spontaneously crying, vigorous with a good heart rate, it’s appropriate to stimulate, warm & dry the child immediately; communicate that you’re happy for this to be done.

The Cochrane review of intubation for meconium says

“Routine endotracheal intubation at birth in vigorous term meconium-stained babies has not been shown to be superior to routine resuscitation including oro-pharyngeal suction. This procedure cannot be recommended for vigorous infants until more research is available.” (Halliday et al).

I tend to think of meconium posing two threats; firstly, a large plug in a major airway leading to hypoventilation/asphyxia, and secondly, the more distal effects causing small airway plugging, and eventually inflammation and the meconium aspiration syndrome.

The meconium aspirator aka the yellow rocket.


If you’re an ‘experienced operator’ then neonatal intubation is a good way to clear the cords. There’s a growing trend away from ETT suctions for meconium, alluded to in the 2010 revision of the ILCOR NRP guidelines. My impression is that time tends to be wasted placing the tube, attaching the yellow rocket, the ventilating the child. Whilst it’s a very important skill to have, the main outcome for the baby is time to airway; the sooner, the better. If in doubt, I use a ‘wiggly worm’ 8FG in the oropharynx & nares and start ventilating. The counterpoint to this, of course, is that visualization of the cords with direct laryngoscopy allows you to see if there really is meconium between the cords. You need to do what you’re comfortable with. Remember, if you’ve done the ETT suction and the child needs a definitive airway for ongoing management, you’ll need a fresh ETT.


7. SpO2 probe

A SpO2 trace is now the standard in neonatal resus. The old adage of treating the patient, not the numbers is essential here; but if the child’s SpO2 are low, titrate your FiO2 to match. The right hand is best, as it’s pre-ductal. The probes themselves can be challenging to attach or have poor traces, so one with a visible waveform is helpful. Also helpful is some thick tape (microcosm is my preferred), as often the infrared sensor and infrared heater on a wet, sticky hand can cause the probe to simply not read.


8. Nasogastric tube and 20mL syringe

These can be helpful if you’ve been giving baby PEEP or IPPV for a prolonged period. A significant amount of gas inevitably makes its way into the gut, and 20+mL in the abdomen can have a compressive effect on the thorax. Learn to put them in – the Special Care nurses are usually more than happy to teach you how to measure and put them in on some of the babies who are ‘feeding & growing’.


9. Circulation

Ask your assistant to tap the heart rate. Saying “it’s fine” isn’t quite the level of detail you need, particularly if the rest of the clinical picture doesn’t fit. It saves time on the practice of counting for 6 seconds and multiplying by ten, a challenging calculation in the heat of a resus. Best of all, tapping the rate gives you ‘real-time’ data. Importantly, if the assistant is struggling to palpate or auscultate a pulse, you can listen yourself and move to the appropriate level of the algorithm.


10. Disability

If the baby is flat but physiologically not terrible, think about HIE (there’s a post coming in the next few weeks). For any prolonged resus, check a BSL early.

Read the next ten tips here.


Selected references

Probyn ME et al. Positive end expiratory pressure during resuscitation of premature lambs rapidly improves blood gases without adversely affecting arterial pressure. Pediatr Res. 2004 Aug;56(2):198-204. Epub 2004 Jun 4. –

NeoResus programme –

ARC guidelines for Newborn Life Support –

Armstrong L, Stenson BJ. Use of umbilical cord blood gas analysis in the assessment of the newborn. Archives of Disease in Childhood Fetal and Neonatal Edition. 2007;92(6):F430-F434. doi:10.1136/adc.2006.099846. –

Halliday HL, Sweet DG. Endotracheal intubation at birth for preventing morbidity and mortality in vigorous, meconium-stained infants born at term. Cochrane Database of Systematic Reviews 2001, Issue 1. Art. No.: CD000500. DOI: 10.1002/14651858.CD000500.;jsessionid=C698844E8E4F962282FE64763EF88FE6.f01t02

Perlman, J et al. on behalf of the NEONATAL RESUSCITATION CHAPTER COLLABORATORS. Special Report Neonatal Resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.  Pediatrics published online Oct 18, 2010; DOI: 10.1542/peds.2010-2972B –

The Sugar Babies Trial – Dextrose gel for neonatal hypoglycaemia

Cite this article as:
Tessa Davis. The Sugar Babies Trial – Dextrose gel for neonatal hypoglycaemia, Don't Forget the Bubbles, 2014. Available at:

You are called to the post-natal wards to review an infant of a diabetic mother. He is Day 1 and has a BSL of 2.4. Do you give an IV bolus? Do you feed? What about dextrose gel? We summarise The Sugar Babies Study looking at the use of dextrose gel in this situation.