Skip to content

ED attendance following MenB vaccination


Share on facebook
Share on twitter
Share on linkedin
Share on whatsapp

In September  2015, the UK introduced the 4Conjugate Meningococcal B vaccine to the routine immunisation schedule, to be given at 2 and 4 months of age. Those of us who’ve witnessed the devastating effects of meningococcal sepsis welcomed this warmly. There was however a small catch. It was recognised that one of the effects of the vaccination was to produce a fever in the recipient shortly after administration, and parents were advised to give paracetamol.

This of course posed a dilemma to the ED physician met with a febrile infant post immunisation. Was the fever solely vaccine related or was it the presentation of a serious bacterial infection? Somewhat unhelpfully there was no, and still is no, national guidance on what to do. Do we assume all fevers are vaccine related and risk missing a septic infant, or do we assume all are possibly septic and risk over-treating?

Several teams in the UK are currently auditing their practices and publishing their findings. The first group to do so was in Northern Ireland  – publishing their findings in the Archives of Disease in Childhood. This is an important start to collecting data to allow us to come up with some guidance and to this end I have summarised the paper in the following infographic.


About the authors

  • Ian is a Paediatric Emergency Medicine Consultant based in Derby. He loves #FOAMed, Apple products, Comics, running and his family. In that order. He dislikes cauliflower cheese.


High flow therapy – when and how?

Chest compressions in traumatic cardiac arrest

Searching for sepsis

The missing link? Children and transmission of SARS-CoV-2

Don’t Forget the Brain Busters – Round 2

An evidence summary of Paediatric COVID-19 literature


The fidget spinner craze – the good, the bad and the ugly

Parenteral Nutrition

Leave a Reply

Your email address will not be published.

1 thought on “ED attendance following MenB vaccination”

  1. This study is so relevant and timely in many ways. 4CmenB does offer additional protection to other strains of Meningcoccal infections as well. The presence of fever can cause a problem when they present to ED in terms of clinicians dilemma but can also cause increased parental concern which may potentially result in vaccine hesitancy and an association and omission bias to set in. Despite the prophylactic therapy with 2 to 3 doses of paracetamol there still are quite a lot of febrile babies.



We use cookies to give you the best online experience and enable us to deliver the DFTB content you want to see. For more information, read our full privacy policy here.