Teething trouble

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As the smallest member of the clan grows older it’s time for my reality based revision to move on from normal neonates to something else. We’ve made it through neonatal nasties and tourniquets on toes. It’s something more commonplace that keeps us up at night – something we’ve all been through – teething.

Only about 1 in 2000 babies are actually born with teeth, most of us had to wait a while before they came through. Cutting through the gingiva from their origin in the mandible/maxilla causes localized trauma and inflammation as well as a number of systemic effects such as a low grade fever and lose stools. Local effects and systemic effects are mediated by cytokine and prostaglandin release as well as by the possible translocation of oral bacteria through the gingival breach.

The embryology of teeth

Teeth develop from the ectoderm of the first pharyngeal arch and elements of the neural crest at around 6 weeks of embryonic development. Layers of cells develop as epithelial thickenings before moving through the stages of bud, cap, bell and then terminal differentiation into individual teeth. The odontoblasts (derived from the neural crest) form the predentin before calcifying to dentin.  It’s the ameloblasts that produce the tooth enamel.

Natal teeth (those present at birth) have a genetic predisposition with up to 60% of cases reporting a family history. They are also associated with an increased incidence of cleft lip/palate. Natal teeth are a known feature of :-

  • Ellis-van Creveld syndrome (chondroectodermal dysplasia)
  • Jackson-Lawler syndrome (pachyonychia congenital 2)
  • Steatocystoma multiplex with natal teeth
  • Hallerman-Streiff syndrome (oculomandibulofacial syndrome with hypotrichosis)

Teeth erupt in a predictable order.

 

How do you number the primary teeth?

There are almost as many numbering schemes as there are teeth. In Australia we use the Fédération Dentaire Internationale – take a look at the graphic below to refresh your memory.

If you work in the US you might choose the universal numbering system, which is not, as you might think, used universally.

Common symptoms of teething

Macknin et al. convinced some of their co-workers at the Cleveland Clinic to keep an 8 month log of 125 of their children. They recorded twice daily temperature measurements as well as filling in a daily symptom report and a record of their dental eruptions. Despite the fact that it seems that my children were teething all of the time they found that symptoms increased 4 days before an eruption, the day of and 3 days after – just an 8 day window. The parents reported drooling, sucking and general grumpiness coupled with the presence of a facial rash and ear or gum rubbing.

Though teething has been shown to raise ones temperature, it is only by a miniscule amount, around 0.6°C and that will be dependent on how it accurately it is measured. The parents in the Macknin cohort all used tympanic thermometers and whilst they are not overly accurate for individual measurements there were used to compare like with like.

Myths surrounding teething

The Macknin et al survey also refuted some common misconceptions. Teething was NOT associated with looser stools, vomiting or high temperatures. The problem is that these myths persist, not only in the general population but also amongst healthcare professionals. Admittedly, I was taught nothing about teething in medical school (or since, hence this post). A survey carried out in New Zealand found that 31% of health care professionals though that teething could cause nappy rash, 27% thought it could cause diarrhoea, 19% a runny nose and  though that teething could cause mouth ulcers.

So how should we treat the pain of erupting teeth?

Teething isn’t the life threatening illness that we once thought it was, but it certainly is sanity threatening for a parent.

Some infants achieve some degree of pain relief by chewing on anything they can.  Solid, silicone based teething rings are probably safer than the water filled variety as they cannot leak. Other parents swear by frozen veggies.

Most of the over-the-counter teething gels contain lignocaine hydrochloride.

Other teething gels, such as Bonjela® contain choline salicylate. These have a local anti-inflammatory as well as local anaesthetic effect. The salicylate component was removed from the UK formulation back in 2002 though there have been case reports of chronic salicylate toxicity in Australia.

There is also the option of using systemic analgesia in the form of appropriate weight-based doses of paracetamol.

And, more importantly, should we NOT treat teething pain?

Whilst it was not until the mid 19th century that teething stopped being listed as a cause of death in young infants it is now more likely that some of the treatments are more deadly.

Lancing (forming a cross-shaped incision over the troubling tooth) was a popular form of treatment in 16th century Europe and persisted until the late 19th century where it fell out of favour. Despite this a similar practice takes place in sub-Saharan Africa today. Removing the budding ‘tooth worms’ with non-sterile implements like knitting needles and bicycle spokes is a form of infant oral mutilation. Healers think the ‘tooth worms’ cause some of the common diarrhoeal illnesses – the erupting tooth bud looks similar to parasitic worms found in stools. If the child does not suffer from serious infection then they may still go on to develop permanent facial disfigurement.

Whilst we know that homeopathy is of no benefit, Hyland’s baby teething tablets were withdrawn in the US after concerns that non-homeopathic does of belladonna extract may have led to around 400 adverse events and 10 deaths. Whilst the alkaloid has not been found in the Australian product, the supplier, in conjunction with the TGA initiated a recall.

Amber necklaces, all the rage with a certain sector of the populace, have a number of health benefits (allegedly) – including reducing inflammation and the pain of teething. I’ve not found any high, medium, or low level evidence to confirm these claims but I have found a number of case reports detailing near strangulation events. Teething toddlers are inquisitive creatures. As they clamber over the furniture in their quest for something else valuable to break the necklace may get caught, leading to near-fatal consequences. One of our roles in emergency medicine is to advocate for those patients that cannot speak for themselves. As Tim Horeczko would say “You are the champion of the child in front of you.

 

Next time I’ll look at some basic dental anatomy, dealing with dental damage and how much you should leave for the Tooth Fairy.

References

Macknin ML, Piedmonte M, Jacobs J, Skibinski C. Symptoms associated with infant teething: a prospective study. Pediatrics. 2000 Apr 1;105(4):747-52.

Wake M, Hesketh K, Lucas J. Teething and tooth eruption in infants: a cohort study. Pediatrics. 2000 Dec 1;106(6):1374-9.

Jaber L, Cohen IJ, Mor A. Fever associated with teething. Archives of Disease in Childhood. 1992 Feb 1;67(2):233-4.

Wake M, Hesketh K. Teething symptoms: cross sectional survey of five groups of child health professionals. Bmj. 2002 Oct 12;325(7368):814.

McIntyre GT, McIntyre GM. Teething troubles?. British Dental Journal. 2002 Mar 9;192(5):251-5.

Zone CP, Guide S. Teething pain in babies. Sign. 2017 Jan 13;3531(937).

Hudson A, Blake K, McLaughlin R. Amber jewellery: A dangerous popular trend for toddlers during their teething months and beyond. Journal of paediatrics and child health. 2016 Apr 1;52(4):470-.

Voelker R. Safe Relief for Teething Symptoms. JAMA. 2016 Nov 15;316(19):1957-.

Ispas RS, Mahoney EK, Whyman RA. Teething signs and symptoms: persisting misconceptions among health professionals in New Zealand. New Zealand Dental Journal. 2013 Mar 1;109

Williams GD, Kirk EP, Wilson CJ, Meadows CA, Chan BS. Salicylate intoxication from teething gel in infancy. Med J Aust. 2011 Feb 7;194(3):146-8.

Girgis S, Gollings J, Longhurst R, Cheng L. Infant oral mutilation–a child protection issue?. British dental journal. 2016 Apr 8;220(7):357-60.

 

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An Emergency Physician with a special interest in education and lifelong learning. When not drinking coffee and reading Batman comics he is playing with his children.

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2 Responses to "Teething trouble"

  1. Dilshad Marikar
    Dilshad Marikar 3 months ago .Reply

    Thanks Andrew, parents intermittently ask me about teething and fever and I keep forgetting to do a literature review – thanks for doing one for me. Minor point, you mention that that the Macknin survey did not report an association between teething and loose stool, but your second paragraph loose stools are mentioned as a systemic effect

  2. Andrew Tagg
    Andrew Tagg 3 months ago .Reply

    Thanks Dilshad, that escaped my eager editing eye. Text changed.

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