Immune deficiencies

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This looks like a nice overview and reference article.

 The article is available here.

Immune deficiencies in children: an overview

Arch Dis Child Educ Pract Ed doi:10.1136/archdischild-2012-302278

S Jyothi1, S Lissauer2,3, S Welch3, S Hackett3 Birmingham Childrens Hospital

Primary immune deficiencies (PIDs) are disorders of the immune system that result in increased susceptibility to infectious disease, autoimmunity and malignancy. They are challenging to paediatricians as they can present anytime from birth to adolescence with a wide variety of signs and symptoms. It is important to diagnose PIDs promptly, especially more severe forms to prevent significant morbidity and mortality. However, significant challenges exist in deciding which children to investigate and when. We aim to give a basic understanding of the human immune system, the different presentations in a child that should alert a paediatrician about the possibility of PID and the possible underlying diagnosis. Additionally, we have developed a framework for a stepwise approach to investigating these children.

 

Other relevant material

Immunodeficiency for the General Paediatrician – in 2 slides! by Penelope Bryant

 

 

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Prof South is a paediatrician and intensivist based at Royal Children's Hospital, Melbourne. He regularly blogs on line Mike's webpage
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